Investigation of regulators that control the pro-survival molecule MCL1 and its stabililty in lymphoma and myeloma cells
Investigation of regulators that control the pro-survival molecule MCL1 and its stabililty in lymphoma and myeloma cells
控制促生存分子 MCL1 的调节因子及其在淋巴瘤和骨髓瘤细胞中的稳定性的研究
批准号：
nhmrc : 1075151
负责人：
金额：
$11.28万
依托单位国家：
澳大利亚
项目类别：
Postgraduate Scholarships
财政年份：
2014
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2014-01-01 至 2018-12-31
中文摘要
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英文摘要
B cell malignancies are common and in many cases result in mortality. The BCL-2 family protein MCL-1 has been shown to be over-expressed in many B cell malignancies. However, the regulation and biology of MCL-1 in these cancers remains largely unknown. We aim to define mechanisms that control regulation of MCL-1 expression in cancer cells at the transcriptional and protein level and hence identify new therapeutic targets.
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