Elucidating the interplay between two chromatin regulators HDA8 and ELP3 in dynamic control of primary and secondary metabolic networks
阐明两个染色质调节因子 HDA8 和 ELP3 在初级和次级代谢网络动态控制中的相互作用
基本信息
- 批准号:2123470
- 负责人:
- 金额:$ 100.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project will yield knowledge on how plants coordinate metabolic networks to produce specialized metabolites that facilitate plant interactions with their environment, ranging from attracting pollinators and seed dispersers to protecting themselves from biotic and abiotic stresses. To date, it remains largely unknown how metabolic networks are regulated to balance the needs for maintaining essential functions and producing specialized metabolites. This project will shed light on chromatin regulatory mechanisms that coordinate metabolic networks to produce volatile secondary metabolites, by testing the hypothesis that an interplay between two chromatin regulators controls the dynamic metabolic flux through primary and secondary metabolic pathways. The obtained knowledge has practical implications for both agriculture and ecology, with potential to improve plant reproductive success, plant defense and stress responses, crop nutritional value, and yield of high value phytochemicals. This project will provide multidisciplinary training for the next generation of scientists, including minorities and high school students, in STEM research. Preliminary studies using Petunia hybrida flowers as a model system led to the hypothesis that Histone deacetylase 8 (PhHDA8) works with the histone acetyltransferase PhELP3 to regulate primary and secondary metabolic networks responsible for the biosynthesis and emission of volatile secondary compounds. To test this hypothesis, the following research objectives will be performed: (1) determining the impact of PhHDA8 and PhELP3 on dynamics of primary and secondary metabolic networks via metabolic profiling; (2) deciphering the genome-wide targets of PhHDA8 and PhELP3 in primary and secondary metabolic networks using functional genomics approaches; and (3) elucidating the molecular mechanisms coordinating PhHDA8 and PhELP3 activities through biochemical approaches. This work will provide important mechanistic insights into the mode of action and interaction of histone acetylation proteins. The obtained knowledge will have a far-reaching impact on understanding chromatin level regulation underlying the chemical diversity found in nature and airborne communications in the plants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该项目将提供有关植物如何协调代谢网络以产生促进植物与环境相互作用的专门代谢物的知识,从吸引传粉者和种子传播者到保护自己免受生物和非生物胁迫。迄今为止,代谢网络是如何被调节以平衡维持基本功能和产生专门代谢物的需要的,这在很大程度上仍然是未知的。该项目将通过测试两种染色质调节剂之间的相互作用通过初级和次级代谢途径控制动态代谢通量的假设,阐明协调代谢网络产生挥发性次级代谢物的染色质调节机制。所获得的知识对农业和生态学都具有实际意义,具有提高植物繁殖成功率、植物防御和胁迫反应、作物营养价值和高价值植物化学物质产量的潜力。该项目将为包括少数民族和高中生在内的下一代科学家提供STEM研究方面的多学科培训。以矮牵牛(Petunia hybrida)花为模型系统的初步研究表明,组蛋白去乙酰化酶8 (PhHDA8)与组蛋白乙酰转移酶PhELP3共同调节负责挥发性次生化合物生物合成和释放的初级和次级代谢网络。为了验证这一假设,将进行以下研究目标:(1)通过代谢谱分析确定PhHDA8和PhELP3对初级和次级代谢网络动力学的影响;(2)利用功能基因组学方法破译PhHDA8和PhELP3在初级和次级代谢网络中的全基因组靶点;(3)通过生化途径阐明PhHDA8和PhELP3活性协调的分子机制。这项工作将为组蛋白乙酰化蛋白的作用模式和相互作用提供重要的机制见解。所获得的知识将对理解染色质水平调控在自然界中发现的化学多样性和植物中的空气传播具有深远的影响。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ying Li其他文献
Dynamic changes of HVR1 quasispecies in chronic hepatitis C after IFN therapy
慢性丙型肝炎IFN治疗后HVR1准种的动态变化
- DOI:
- 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
Lin Zhang;G. Zhao;Ying Li;Li - 通讯作者:
Li
Facile fabrication of bubbles-enhanced flexible bioaerogels for efficient and recyclable oil adsorption
轻松制造气泡增强型柔性生物气凝胶,实现高效且可回收的油吸附
- DOI:
10.1016/j.cej.2020.126240 - 发表时间:
2020-12 - 期刊:
- 影响因子:15.1
- 作者:
Qiaozhi Wang;Yan Qin;Chunlong Xue;Haoran Yu;Ying Li - 通讯作者:
Ying Li
Compression behavior of the graded metallic auxetic reentrant honeycomb: Experiment and finite element analysis
分级金属拉胀凹入蜂窝的压缩行为:实验和有限元分析
- DOI:
10.1016/j.msea.2019.04.116 - 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Dengbao Xiao;Zhichao Dong;Ying Li;Wenwang Wu;Daining Fang - 通讯作者:
Daining Fang
Effects of Event-Related Centrality on Concept Accessibility
事件相关中心性对概念可及性的影响
- DOI:
10.1080/01638530701226204 - 发表时间:
2007 - 期刊:
- 影响因子:2.2
- 作者:
L. Mo;Hongmin Chen;Ying Li;Zhe Chen;Xianyou He - 通讯作者:
Xianyou He
The Efficacy and Neural Correlates of ERP-based Therapy for OCD & TS: A Systematic Review and Meta-Analysis.
基于 ERP 的强迫症治疗的疗效和神经相关性
- DOI:
10.37766/inplasy2021.12.0112 - 发表时间:
2021 - 期刊:
- 影响因子:1.8
- 作者:
Junjuan Yan;Li;Mengyu Wang;Yonghua Cui;Ying Li - 通讯作者:
Ying Li
Ying Li的其他文献
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{{ truncateString('Ying Li', 18)}}的其他基金
CLIMA/Collaborative Research: Discovery of Covalent Adaptable Networks for Sustainable Manufacturing and Recycling of Wind Turbine Blades
CLIMA/合作研究:发现用于风力涡轮机叶片可持续制造和回收的共价适应性网络
- 批准号:
2332276 - 财政年份:2024
- 资助金额:
$ 100.2万 - 项目类别:
Standard Grant
Collaborative Research: Multiscale Analysis and Simulation of Biofilm Mechanics
合作研究:生物膜力学的多尺度分析与模拟
- 批准号:
2313746 - 财政年份:2023
- 资助金额:
$ 100.2万 - 项目类别:
Continuing Grant
PFI-TT: Scalable Manufacturing of Novel Catalysts for Converting CO2 to Valuable Products
PFI-TT:可规模化生产将二氧化碳转化为有价值产品的新型催化剂
- 批准号:
2326072 - 财政年份:2023
- 资助金额:
$ 100.2万 - 项目类别:
Continuing Grant
Collaborative Research: Interfacial Self-healing of Nanocomposite Hydrogels
合作研究:纳米复合水凝胶的界面自修复
- 批准号:
2314424 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Standard Grant
Collaborative Research: Multiscale Analysis and Simulation of Biofilm Mechanics
合作研究:生物膜力学的多尺度分析与模拟
- 批准号:
2205007 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Continuing Grant
CAREER: Machine Learned Coarse-grained Modeling for Mechanics of Thermoplastic Elastomers
职业:热塑性弹性体力学的机器学习粗粒度建模
- 批准号:
2323108 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Standard Grant
Collaborative Research: Using Anisotropic Surface Coating of Nanoparticles to Tune Their Antimicrobial Activity
合作研究:利用纳米颗粒的各向异性表面涂层来调节其抗菌活性
- 批准号:
2313754 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Continuing Grant
Collaborative Research: Using Anisotropic Surface Coating of Nanoparticles to Tune Their Antimicrobial Activity
合作研究:利用纳米颗粒的各向异性表面涂层来调节其抗菌活性
- 批准号:
2153894 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Continuing Grant
Unraveling Mechanics of High Strength and Low Stiffness in Polymer Nanocomposites through Integrated Molecular Modeling and Nanomechanical Experiments
通过集成分子建模和纳米力学实验揭示聚合物纳米复合材料的高强度和低刚度力学
- 批准号:
2316200 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Standard Grant
CRII: OAC: A Hybrid Finite Element and Molecular Dynamics Simulation Approach for Modeling Nanoparticle Transport in Human Vasculature
CRII:OAC:一种混合有限元和分子动力学模拟方法,用于模拟人体脉管系统中纳米颗粒的传输
- 批准号:
2326802 - 财政年份:2022
- 资助金额:
$ 100.2万 - 项目类别:
Standard Grant
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