Point-of-Delivery Prenatal Test Results through mHealth to Improve Birth Outcome
通过移动医疗提供分娩点产前检测结果以改善出生结果
基本信息
- 批准号:9020158
- 负责人:
- 金额:$ 15.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-24 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAccountingAdoptionAffectAfricanAlgorithmsAnti-Retroviral AgentsAssesB-LymphocytesBirthBloodCancer EtiologyCaringCase Report FormCellular PhoneCessation of lifeChildChronic Hepatitis BChurchCollaborationsCommunitiesCommunity HospitalsCommunity NetworksCountryDataData AnalysesDatabasesDecision ModelingDeveloping CountriesDiseaseDoseEarly InterventionEarly identificationEffectivenessElectronicsEvaluationEvidence based interventionFocus GroupsFoundationsGenotypeGoalsHBV GenotypeHIVHIV InfectionsHealth TechnologyHealth educationHepatitis BHepatitis B PrevalenceHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B VirusHourHuman immunodeficiency virus testIllinoisImmunizationIncomeInfantInfection preventionInformation TechnologyInstitutionInterventionInterviewLaboratoriesLifeMalignant neoplasm of liverManualsMapsMedicalMorbidity - disease rateMothersNevadaNewborn InfantNigeriaOnline SystemsOutcomeParticipantPenicillinsPerinatalPhasePrayersPregnancyPregnant WomenPreparationPreventionPrevention programProgram EffectivenessProphylactic treatmentQuality of CareReadingRecordsResearch InfrastructureResourcesRiskSecureServicesSickle CellSickle Cell AnemiaSickle Cell TraitSiteSmart CardTechnologyTest ResultTestingUnited States National Institutes of HealthUniversitiesVirus DiseasesWitWomanantiretroviral therapybasedata managementdisease transmissiondisorder preventionfollow-upimprovedinformantinnovationmHealthmortalityoperationphase III trialprenatalpreventprogramspublic health relevancescreeningsicklingsocial stigmatransmission processuptakeusability
项目摘要
DESCRIPTION (provided by applicant): Nigeria is one of the 22 countries identified by the WHO to account for 90% of pregnant women living with HIV. Despite expansions of HIV prevention programs in Nigeria, only 14% of pregnant women were tested for HIV; only 27% of HIV-infected pregnant women received WHO recommended antiretroviral (ARV) therapy; only 11% of HIV-exposed infants received ARV prophylaxis for prevention of mother-to-child HIV transmission (PMTCT) and only 3.9% of exposed infants received appropriate testing within two months and an estimated 51,000 infants became infected with HIV in 2013. Risk of perinatal transmission is increased when a pregnant woman is co-infected with HIV and hepatitis B virus (HBV) infection which remain endemic in Nigeria where liver cancer is now the most common cause of cancer death. Children with sickle cell disease (SCD) are also at increased risk of HIV due to frequent blood transmission and an estimated 50-80% of these children die before their 5th birthday. Despite availability of simple inexpensive interventions such as penicillin prophylaxis, hepatitis B vaccine or antiretroviral prophylaxis, implementation remains inconsistent. In 2013, we demonstrated that the Healthy Beginning Initiative [HBI], a congregation-based intervention that uses prayer session to identify pregnant women early, baby shower to implement an integrated testing (HIV- plus hepatitis B and sickle cell genotype) and baby reception for follow up is acceptable and effective in increasing HIV testing among pregnant women. For this application, we will develop and test the feasibility, acceptability and usability of a web-based database and medical decision model that captures results for HIV, HBV and sickle cell genotype obtained during HBI participants; store data in a secure, web-based database; encrypt data on a "smart card" which is given to participants, and make these data available at the point-of- delivery using a cell-phone application to read the "smart card". Data on the web-based database can also be accessed directly using the cell phone application. Evidence exists that when clinician have maternal records available at the point of delivery, they are more likely to initiate antiretroviral prophylaxis for HIV-exposed infants, administer first dose of hepatitis B vaccine with 24 hours for infants born to women who have positive hepatitis B surface antigen and screen infants born to mothers with sickle cell trait to allow early identification and initiation of penicillin prophylaxis for infants who have sickle cel disease. The ultimate endpoint for the Phase III trial is reduction in mortality among children wit sickle cell disease and prevention of perinatal transmission of HIV and HBV infections. This proposal is collaboration among Sunrise Foundation (local PEPFAR-supported partner in Nigeria); University of Illinois Urbana-Champaign (concept mapping, focus group and key informant interviews); Xavier University (data management and analysis) and University of Nevada, Reno (overall oversight and evaluation of program effectiveness).
描述(申请人提供):尼日利亚是世界卫生组织确定的22个国家之一,占携带艾滋病毒的孕妇的90%。尽管尼日利亚扩大了艾滋病毒预防方案,但只有14%的孕妇接受了艾滋病毒检测;只有27%的艾滋病毒感染孕妇接受了世卫组织推荐的抗逆转录病毒(ARV)疗法;只有11%的艾滋病毒感染者接受了预防艾滋病毒母婴传播(PMTCT)的ARV预防;只有3.9%的艾滋病毒感染者在两个月内接受了适当的检测,2013年估计有51,000名婴儿感染了艾滋病毒。当孕妇同时感染艾滋病毒和乙肝病毒(乙肝病毒)时,围产期传播的风险会增加,这两种病毒在尼日利亚仍然流行,在尼日利亚,肝癌现在是癌症死亡的最常见原因。患有镰状细胞病(SCD)的儿童由于频繁的血液传播也增加了感染艾滋病毒的风险,估计这些儿童中有50%-80%在5岁生日之前死亡。尽管提供了简单、廉价的干预措施,如青霉素预防、乙肝疫苗或抗逆转录病毒预防,但实施情况仍然不一致。2013年,我们证明了健康开始倡议[HBI],这是一种以会众为基础的干预措施,使用祈祷会及早识别孕妇,通过婴儿淋浴来实施综合检测(艾滋病毒+乙肝和镰状细胞基因型),并接受婴儿进行后续检查,这在增加孕妇艾滋病毒检测方面是可以接受和有效的。对于这一应用,我们将开发和测试基于网络的数据库和医疗决策模型的可行性、可接受性和可用性,该模型捕获在HBI参与者期间获得的艾滋病毒、乙肝和镰状细胞基因型的结果;将数据存储在安全的、基于Web的数据库中;对发给参与者的“智能卡”上的数据进行加密,并使用手机应用程序在交付点使用读取“智能卡”的数据。还可以使用手机应用程序直接访问基于网络的数据库上的数据。有证据表明,当临床医生在分娩时有产妇记录时,他们更有可能开始对感染艾滋病毒的婴儿进行抗逆转录病毒预防,为乙肝表面抗原阳性的母亲所生的婴儿24小时接种第一剂乙肝疫苗,并对具有镰状细胞特征的母亲所生的婴儿进行筛查,以便早期识别并开始为患有镰刀病的婴儿进行青霉素预防。第三阶段试验的最终终点是降低患有镰状细胞疾病的儿童的死亡率,并防止艾滋病毒和乙肝病毒感染的围产期传播。这项建议是与日出基金会(尼日利亚当地PEPFAR支持的合作伙伴)、伊利诺伊大学厄巴纳-香槟分校(概念图、焦点小组和关键线人访谈)、泽维尔大学(数据管理和分析)和内华达大学雷诺分校(全面监督和评估项目有效性)之间的合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Echezona Edozie Ezeanolue其他文献
Echezona Edozie Ezeanolue的其他文献
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{{ truncateString('Echezona Edozie Ezeanolue', 18)}}的其他基金
Adolescent Coordinated Transition (ACT) to Improve Health Outcomes among Nigerian HIV Youth
青少年协调过渡 (ACT) 旨在改善尼日利亚艾滋病毒青少年的健康状况
- 批准号:
9206425 - 财政年份:2016
- 资助金额:
$ 15.67万 - 项目类别:
Intervention for Sustained Testing and Retention (iSTAR) Among HIV-infected Patients
HIV 感染者持续检测和保留干预 (iSTAR)
- 批准号:
9337549 - 财政年份:2016
- 资助金额:
$ 15.67万 - 项目类别:
Point-of-Delivery Prenatal Test Results through mHealth to Improve Birth Outcome
通过移动医疗提供分娩点产前检测结果以改善出生结果
- 批准号:
9149340 - 财政年份:2015
- 资助金额:
$ 15.67万 - 项目类别:
Comparative Effectiveness of Congregation and Clinic Based Approaches to PMTCT
基于会众和临床的 PMTCT 方法的比较效果
- 批准号:
8551683 - 财政年份:2012
- 资助金额:
$ 15.67万 - 项目类别:
Comparative Effectiveness of Congregation and Clinic Based Approaches to PMTCT
基于会众和临床的 PMTCT 方法的比较效果
- 批准号:
8433153 - 财政年份:2012
- 资助金额:
$ 15.67万 - 项目类别:
Comparative Effectiveness of Congregation and Clinic Based Approaches to PMTCT
基于会众和临床的 PMTCT 方法的比较效果
- 批准号:
8879485 - 财政年份:2012
- 资助金额:
$ 15.67万 - 项目类别:
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