Point-of-Delivery Prenatal Test Results through mHealth to Improve Birth Outcome

通过移动医疗提供分娩点产前检测结果以改善出生结果

基本信息

项目摘要

 DESCRIPTION (provided by applicant): Nigeria is one of the 22 countries identified by the WHO to account for 90% of pregnant women living with HIV. Despite expansions of HIV prevention programs in Nigeria, only 14% of pregnant women were tested for HIV; only 27% of HIV-infected pregnant women received WHO recommended antiretroviral (ARV) therapy; only 11% of HIV-exposed infants received ARV prophylaxis for prevention of mother-to-child HIV transmission (PMTCT) and only 3.9% of exposed infants received appropriate testing within two months and an estimated 51,000 infants became infected with HIV in 2013. Risk of perinatal transmission is increased when a pregnant woman is co-infected with HIV and hepatitis B virus (HBV) infection which remain endemic in Nigeria where liver cancer is now the most common cause of cancer death. Children with sickle cell disease (SCD) are also at increased risk of HIV due to frequent blood transmission and an estimated 50-80% of these children die before their 5th birthday. Despite availability of simple inexpensive interventions such as penicillin prophylaxis, hepatitis B vaccine or antiretroviral prophylaxis, implementation remains inconsistent. In 2013, we demonstrated that the Healthy Beginning Initiative [HBI], a congregation-based intervention that uses prayer session to identify pregnant women early, baby shower to implement an integrated testing (HIV- plus hepatitis B and sickle cell genotype) and baby reception for follow up is acceptable and effective in increasing HIV testing among pregnant women. For this application, we will develop and test the feasibility, acceptability and usability of a web-based database and medical decision model that captures results for HIV, HBV and sickle cell genotype obtained during HBI participants; store data in a secure, web-based database; encrypt data on a "smart card" which is given to participants, and make these data available at the point-of- delivery using a cell-phone application to read the "smart card". Data on the web-based database can also be accessed directly using the cell phone application. Evidence exists that when clinician have maternal records available at the point of delivery, they are more likely to initiate antiretroviral prophylaxis for HIV-exposed infants, administer first dose of hepatitis B vaccine with 24 hours for infants born to women who have positive hepatitis B surface antigen and screen infants born to mothers with sickle cell trait to allow early identification and initiation of penicillin prophylaxis for infants who have sickle cel disease. The ultimate endpoint for the Phase III trial is reduction in mortality among children wit sickle cell disease and prevention of perinatal transmission of HIV and HBV infections. This proposal is collaboration among Sunrise Foundation (local PEPFAR-supported partner in Nigeria); University of Illinois Urbana-Champaign (concept mapping, focus group and key informant interviews); Xavier University (data management and analysis) and University of Nevada, Reno (overall oversight and evaluation of program effectiveness).
 描述(由申请人提供):尼日利亚是世界卫生组织确定的22个国家之一,占感染艾滋病毒的孕妇的90%。尽管尼日利亚扩大了艾滋病毒预防方案,但只有14%的孕妇接受了艾滋病毒检测;只有27%感染艾滋病毒的孕妇接受了世卫组织推荐的抗逆转录病毒疗法;只有11%的艾滋病毒暴露婴儿接受了抗逆转录病毒药物预防,以预防母婴传播艾滋病毒(PMTCT),只有3.9%的婴儿接受了抗逆转录病毒药物预防,2013年,约有51,000名婴儿在两个月内接受了适当的检测,并感染了艾滋病毒。当孕妇同时感染艾滋病毒和B型肝炎病毒(HBV)感染时,围产期传播的风险增加,这在尼日利亚仍然是地方病,肝癌现在是癌症死亡的最常见原因。患有镰状细胞病(SCD)的儿童由于频繁的血液传播,感染艾滋病毒的风险也增加了,估计这些儿童中有50-80%在5岁生日前死亡。尽管有青霉素预防、B型肝炎疫苗或抗逆转录病毒预防等简单廉价的干预措施,但执行情况仍然不一致。2013年,我们证明了健康开端倡议[HBI],一种基于教会的干预措施,利用祈祷会及早识别孕妇,婴儿送礼会实施综合检测(艾滋病毒+乙型肝炎B和镰状细胞基因型)和婴儿接收随访,在增加孕妇艾滋病毒检测方面是可以接受和有效的。对于该应用,我们将开发并测试基于网络的数据库和医疗决策模型的可行性、可接受性和可用性,该模型捕获HBI参与者期间获得的HIV、HBV和镰状细胞基因型的结果;将数据存储在安全的基于网络的数据库中;加密发给参与者的“智能卡”上的数据,并使用蜂窝电话应用程序读取“智能卡”,使这些数据在递送点可用。基于网络的数据库上的数据也可以直接使用手机应用程序访问。有证据表明,当临床医生在分娩时有产妇记录时,他们更有可能对接触艾滋病毒的婴儿进行抗逆转录病毒预防,对于B肝炎表面抗原阳性的妇女所生的婴儿,在24小时内接种第一剂B肝炎疫苗,并筛查镰状细胞特征母亲所生的婴儿,以便早期识别并开始对患有镰状细胞特征的婴儿进行青霉素预防。患有镰状细胞病。III期试验的最终终点是降低镰状细胞病儿童的死亡率,预防围产期HIV和HBV感染的传播。这项建议是由日出基金会(在尼日利亚的PEPFAR支持的当地合作伙伴)、伊利诺伊大学厄巴纳-香槟分校(概念图绘制、焦点小组和关键知情人访谈)、泽维尔大学(数据管理和分析)和里诺的内华达州大学(全面监督和评估方案有效性)合作提出的。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reliability of Self-Reported Mobile Phone Ownership in Rural North-Central Nigeria: Cross-Sectional Study.
  • DOI:
    10.2196/mhealth.8760
  • 发表时间:
    2018-03-01
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Menson WNA;Olawepo JO;Bruno T;Gbadamosi SO;Nalda NF;Anyebe V;Ogidi A;Onoka C;Oko JO;Ezeanolue EE
  • 通讯作者:
    Ezeanolue EE
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Echezona Edozie Ezeanolue其他文献

Echezona Edozie Ezeanolue的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Echezona Edozie Ezeanolue', 18)}}的其他基金

Adolescent Coordinated Transition (ACT) to Improve Health Outcomes among Nigerian HIV Youth
青少年协调过渡 (ACT) 旨在改善尼日利亚艾滋病毒青少年的健康状况
  • 批准号:
    9206425
  • 财政年份:
    2016
  • 资助金额:
    $ 16.56万
  • 项目类别:
Intervention for Sustained Testing and Retention (iSTAR) Among HIV-infected Patients
HIV 感染者持续检测和保留干预 (iSTAR)
  • 批准号:
    9337549
  • 财政年份:
    2016
  • 资助金额:
    $ 16.56万
  • 项目类别:
Point-of-Delivery Prenatal Test Results through mHealth to Improve Birth Outcome
通过移动医疗提供分娩点产前检测结果以改善出生结果
  • 批准号:
    9020158
  • 财政年份:
    2015
  • 资助金额:
    $ 16.56万
  • 项目类别:
Comparative Effectiveness of Congregation and Clinic Based Approaches to PMTCT
基于会众和临床的 PMTCT 方法的比较效果
  • 批准号:
    8551683
  • 财政年份:
    2012
  • 资助金额:
    $ 16.56万
  • 项目类别:
Comparative Effectiveness of Congregation and Clinic Based Approaches to PMTCT
基于会众和临床的 PMTCT 方法的比较效果
  • 批准号:
    8433153
  • 财政年份:
    2012
  • 资助金额:
    $ 16.56万
  • 项目类别:
Comparative Effectiveness of Congregation and Clinic Based Approaches to PMTCT
基于会众和临床的 PMTCT 方法的比较效果
  • 批准号:
    8879485
  • 财政年份:
    2012
  • 资助金额:
    $ 16.56万
  • 项目类别:

相似海外基金

Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Will the provision of facilitated support improve the adoption of cloud-based accounting packages, by community sector SMEs?
提供便利支持是否会改善社区中小企业对基于云的会计软件包的采用?
  • 批准号:
    104764
  • 财政年份:
    2019
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Feasibility Studies
Transfer and Institutionalization of Accounting Routine in the Adoption of Management Accounting Systems
采用管理会计系统时会计流程的转移和制度化
  • 批准号:
    16K03991
  • 财政年份:
    2016
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Impact Analysis on Accounting Standards Setting of Political Appointee and the Reality of IFRS Adoption
政治任命会计准则制定的影响分析及采用国际财务报告准则的现实
  • 批准号:
    15K03804
  • 财政年份:
    2015
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A Theoretical and Empirical Study on the Adoption and Practices of a New Public Accounting system for Local Japanese governments
日本地方政府新公共会计制度采用与实践的理论与实证研究
  • 批准号:
    15H03400
  • 财政年份:
    2015
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A Study on the Comprehensive Income from the viewpoint of Convergence and Adoption to International Accounting Standards Board
从国际会计准则委员会趋同和采用的角度研究综合收益
  • 批准号:
    23730444
  • 财政年份:
    2011
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Empirical Study on performance reporting and the convergence and/or adoption of international accounting standards
关于绩效报告以及国际会计准则趋同和/或采用的实证研究
  • 批准号:
    22730376
  • 财政年份:
    2010
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Generation and Adoption of Modern Management Accounting Systems
现代管理会计系统的产生和采用
  • 批准号:
    21830154
  • 财政年份:
    2009
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
A Comprehensive Research on the Adoption of International Accounting Standards
国际会计准则采用的综合研究
  • 批准号:
    14330043
  • 财政年份:
    2002
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A Comparative Research of Management Accounting and Cost Management Issues between American Multinationals and their Japanese Counterparts from the point of adoption and adoption
从采用和采用的角度看美国跨国公司与日本跨国公司管理会计和成本管理问题的比较研究
  • 批准号:
    10630133
  • 财政年份:
    1998
  • 资助金额:
    $ 16.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了