Investigation of the role of novel cell types and metabolites in the pathogenesis of asthma

哮喘是一种慢性呼吸道疾病，困扰着250万澳大利亚人，并对医疗保健系统造成重大负担。哮喘的环境触发因素诱导气道破坏性炎症，这是通过上皮细胞协调的。研究的目的是了解一种新型的气道上皮细胞和一种新型的代谢物如何调节炎症和疾病，并可以在治疗上靶向降低哮喘的严重程度。

Asthma is a chronic disease of the airways that afflicts 2.5 million Australians and poses a significant burden on the healthcare system. Environmental triggers of asthma induce airway destructive inflammation, which is orchestrated through epithelial cells. Investigations are aimed at understanding how a new type of airway epithelial cell and a novel metabolite regulate inflammation and disease and can be therapeutically targeted to reduce the severity of asthma.