Investigating the interaction between susceptibility genes, viral infection, and gut microbiota in inflammation and epithelial repair processes

研究炎症和上皮修复过程中易感基因、病毒感染和肠道微生物群之间的相互作用

• 批准号: nhmrc : 1037658
• 负责人: Dr Gerard Kaiko
• 金额: $ 22万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-interaction-susceptibility-repair-processes/111091
• 关键词: Investigating; interaction; between; susceptibility; genes

Utilising my background in Immunology I will investigate whether specific genetic mutations can create a susceptibility for dysregulation of the flora and immune system within the gut, thus predisposing an individual to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) as well as non-intestinal inflammatory conditions. These diseases are becoming an increasingly prevalent and serious health burden in Australia. We aim to use this knowledge in order to design specific treatments for these diseases.

利用我在免疫学的背景，我将调查是否特定的基因突变可以创建一个肠道内的植物群和免疫系统失调的易感性，从而诱发一个人炎症性肠病（溃疡性结肠炎和克罗恩病）以及非肠道炎症条件。这些疾病正在成为澳大利亚日益普遍和严重的健康负担。我们的目标是利用这些知识来设计针对这些疾病的具体治疗方法。