The role of susceptibility genes and microbiota in inflammatory diseases

易感基因和微生物群在炎症性疾病中的作用

• 批准号: nhmrc : GNT1037658
• 负责人: Dr Gerard Kaiko
• 金额: $ 30.39万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-susceptibility-genes-inflammatory-diseases/1344358
• 关键词: role; susceptibility; genes; microbiota; inflammatory

Utilising my background in Immunology I will investigate whether specific genetic mutations can create a susceptibility for dysregulation of the flora and immune system within the gut, thus predisposing an individual to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) as well as non-intestinal inflammatory conditions. These diseases are becoming an increasingly prevalent and serious health burden in Australia. We aim to use this knowledge in order to design specific treatments for these diseases.

利用我在免疫学的背景，我将调查是否特定的基因突变可以创建一个肠道内的植物群和免疫系统失调的易感性，从而诱发一个人炎症性肠病（溃疡性结肠炎和克罗恩病）以及非肠道炎症条件。这些疾病正在成为澳大利亚日益普遍和严重的健康负担。我们的目标是利用这些知识来设计针对这些疾病的具体治疗方法。