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A Genome Browser On-Ramp to Engage Biologists with Big Data

基因组浏览器入口让生物学家接触大数据

基本信息

批准号：
9043792
负责人：
Sarah C.R. ELGIN
金额：
$ 20.95万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9043792
关键词：
Base Pairing Big Data Bioinformatics Biology Biomedical Research ChIP-seq Chromatin Structure Communicable Diseases Communities Computational Biology Computational Technique Computer software Computers Coupled Crowding Custom DNA Sequence Data Data Set Drops Education Educational Curriculum Educational workshop Elements Ensure Exposure to Faculty Familiarity Family Galaxy Genes Genetic Genome Genomics Goals High-Throughput Nucleotide Sequencing Home environment Imagery Informatics Information Technology Institution Instruction Internet Knowledge Learning Link Malignant Neoplasms Maps Medical Minority Molecular Biology Neurobiology Online Systems Organism Ownership Parasites Parasitology Positioning Attribute Postdoctoral Fellow Problem Solving Ramp Research Research Personnel Research Training Resources Running Schedule Schools Scientist Sequence Analysis Software Engineering Students System Systems Biology Technology Testing Trainers Training Training Work computer science cost experience genome analysis genome annotation genome sequencing graduate student meetings member novel public health relevance skills success tool transcriptome sequencing undergraduate education web site

项目摘要

DESCRIPTION (provided by applicant): The era of "big data" is both exciting and challenging for many biomedical investigators - exciting because of the scientific and medical possibilities, and challenging because of their lack of background in information technology (IT). As DNA sequencing costs continue to drop, many investigators would like to sequence and analyze new genomes as well as build knowledge of genome function through ChIP-seq and RNA-seq technologies, etc., but find themselves limited by the IT demands. Our goal here is to create a widely-accessible Web-based application (christened G-OnRamp) for interactive analysis and visualization of genomic data to analyze and annotate eukaryotic genomes. This project will develop integrated software that will enable any investigator to construct genome browsers with evidence tracks from multiple analysis tools, using the browser to interactively annotate the functional elements of a genome. Project utilization will be amplified by the use of the system in undergraduate education. Genome annotation projects have been shown to provide a terrific vehicle both for bringing bioinformatics into the undergraduate curriculum, and for engaging undergraduates in research. Once they experience some success, and see and appreciate the power of such a system, both biomedical researchers and undergraduates alike may be motivated to learn additional IT skills. Approach: the project is a partnership between the Galaxy Project, a web-based workbench that provides access to a large suite of bioinformatics tools and shared workflows, and the Genomics Education Partnership (GEP), made up of faculty from >100 primarily undergraduate institutions, with broad experience in introducing students to genomics. Aim 1: a collaborative effort between biologists and computer scientists to create better pipelines for genomics analysis, and integrate them with a genome browser construction pipeline that will facilitate genome annotation, enabling numerous distributed projects for both existing and novel genomes (e.g., a parasite). The system will enable biomedical researchers and faculty to set up new, local projects; link users to the needed web resources; and provide a means for collaborative annotation projects. Crowd-sourcing genome annotation will benefit both students and the biomedical research community. Beta-testing of G-OnRamp will be done by GEP faculty and other early adopters. Aim 2: develop training materials on the use of the system for both beginners and experts. This will be done with extensive dialogue between GEP and Galaxy. The final system will be accessible for a novice, and useful for an expert. Aim 3 will focus on dissemination. This will be done through Web-based announcements, short meeting workshops and longer "train the trainer" workshops; introducing the system through the GEP will provide a starting pool of >100 campuses and >1000 undergraduates. Providing broad access to a system for genome analysis and annotation will greatly strengthen bioinformatics research and training in the biomedical sector, enabling both basic and applied studies that will contribute to NHGRI's "base pairs to bedside" charter.