White Matter Connectivity and PD Cognitive Phenotypes
白质连接性和 PD 认知表型
基本信息
- 批准号:8919949
- 负责人:
- 金额:$ 52.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-25 至 2016-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAlzheimer&aposs DiseaseAreaBehavior TherapyBrainClinicalClinical ResearchClinical SciencesCognitionCognitiveCognitive deficitsCountryDataData SetDatabasesDelayed MemoryDementiaDevelopmentDiagnosisDiffusionDiseaseEpisodic memoryExhibitsFiberFunctional ImagingGray unit of radiation doseHealthHeterogeneityHippocampus (Brain)ImageImaging TechniquesImpaired cognitionIndividualInstitutesInterventionInvestigationK-Series Research Career ProgramsMatched GroupMeasurementMeasuresMemoryMemory LossMemory impairmentMethodsModalityMovement DisordersNeurodegenerative DisordersNeuropsychological TestsNeuropsychologyParkinson DiseaseParkinson&aposs DementiaPatientsPatternPhenotypePopulationPrefrontal CortexPsyche structureRecruitment ActivityRelative (related person)ResearchResolutionResourcesRiskRoleSamplingServicesSeveritiesShort-Term MemoryStatistical ModelsSurfaceTranslational ResearchUnited StatesWorkbaseclinically relevantcognitive abilitycognitive changecognitive functioncognitive testingdisease phenotypedisorder controlentorhinal cortexexecutive functionflexibilitygray matterillness lengthimaging modalityin vivoinformation processingmeetingsmemory processneurocognitive testneuroimagingneuropsychologicalneurorestorationnon-motor symptomnovelpeerprocessing speedstandardize measuretherapy designtoolwhite matter
项目摘要
DESCRIPTION (provided by applicant): Parkinson's Disease (PD) affects at least 1.5 million people in the United States alone. One of the most severe non-motor symptoms of PD is cognitive dysfunction involving reduced processing speed/working memory, and/or episodic memory. Relative to other neurodegenerative disorders with cognitive impairment, we know little about the neuroanatomical correlates of cognitive decline in PD. In preliminary work, we have examined brain connectivity associated with cognition in a group of idiopathic non-dementia PD relative to non- PD age-matched peers. Three distinct cognitive phenotypes were observed: a) slow information processing speed with preserved episodic memory, b) episodic memory difficulty with subtle slow information processing speed; and c) normal functioning with no deficits relative to age matched peers. Preliminary results of high angular resolution diffusion imaging suggest unique white matter and gray matter profiles: PD with episodic memory deficits exhibited mesial temporal circuit disruption (i.e., entorhinal-hippocampal connectivity); PD with primary processing speed deficits displayed aberration in the frontal-subcortical white matter circuitry (DLPFcircuit) between the dorsolateral prefrontal cortex and caudate; and PD without cognitive deficits showed circuitry similar to age-matched controls. The present study will recruit
from one of the largest movement disorder databases in the country to investigate working hypotheses regarding memory and processing speed/executive difficulties and regional white matter connectivity within the temporal and frontal-subcortical regions, respectively. Three specific aims will be addressed. Aim 1: to demonstrate the association between memory function and the connectivity between the entorhinal cortex and hippocampus; Aim 2: to examine the relation between reduced processing speed/working memory and integrity within the DLPF cortex to caudate; and Aim 3: to reveal the significance of regional brain connectivity on memory or executive function decline at one and two years post-baseline. A research team specialized in movement disorders, functional and diffusion imaging, neuropsychological assessment, reliable change analyses, and longitudinal statistical modeling will carry out these aims. Study methods will draw from unique PD patient database, state-of-the art imaging techniques, and resources from the General Clinical Research Center within the Clinical and Translational Science Institute.
描述(由申请人提供):帕金森病(PD)仅在美国就影响至少150万人。PD的最严重的非运动症状之一是认知功能障碍,涉及降低的处理速度/工作记忆和/或情景记忆。相对于其他神经退行性疾病与认知功能障碍,我们知道很少的神经解剖学相关的认知功能下降的PD。在初步工作中,我们已经检查了一组特发性非痴呆PD相对于非PD年龄匹配的同龄人与认知相关的脑连接。观察到三种不同的认知表型:a)缓慢的信息处理速度,保留情景记忆,B)情景记忆困难,轻微缓慢的信息处理速度;和c)相对于年龄匹配的同龄人,功能正常,无缺陷。高角分辨率弥散成像的初步结果表明独特的白色物质和灰质轮廓:具有情节记忆缺陷的PD表现出近中颞回路中断(即,内鼻-海马连接);具有初级加工速度缺陷的PD显示背外侧前额叶皮层和尾状核之间的额叶-皮质下白色物质回路(DLPF回路)异常;没有认知缺陷的PD显示与年龄匹配的对照组相似的回路。本研究将招募
来自全国最大的运动障碍数据库之一,以调查关于记忆和处理速度/执行困难以及颞叶和额叶皮层下区域内的区域白色物质连接的工作假设。将讨论三个具体目标。目标1:证明记忆功能与内嗅皮层和海马体之间的连接性之间的关联;目的2:检查降低的处理速度/工作记忆与DLPF皮层至尾状核的完整性之间的关系;以及目的3:揭示区域脑连接性对基线后1年和2年的记忆或执行功能下降的意义。一个专门从事运动障碍、功能和扩散成像、神经心理学评估、可靠的变化分析和纵向统计建模的研究小组将实现这些目标。研究方法将利用独特的PD患者数据库、最先进的成像技术以及临床和转化科学研究所内的一般临床研究中心的资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('CATHERINE E PRICE', 18)}}的其他基金
Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related Dementias
针对阿尔茨海默病和相关痴呆症的围手术期认知麻醉网络 (PeCAN) 计划
- 批准号:
10379966 - 财政年份:2020
- 资助金额:
$ 52.04万 - 项目类别:
Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related Dementias
针对阿尔茨海默病和相关痴呆症的围手术期认知麻醉网络 (PeCAN) 计划
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10596205 - 财政年份:2020
- 资助金额:
$ 52.04万 - 项目类别:
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10121051 - 财政年份:2017
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$ 52.04万 - 项目类别:
PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawing
PRECEDE:通过数字时钟进行术前认知评估
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9975669 - 财政年份:2017
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$ 52.04万 - 项目类别:
PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawing
PRECEDE:通过数字时钟进行术前认知评估
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$ 52.04万 - 项目类别:
White Matter Connectivity and PD Cognitive Phenotypes
白质连接性和 PD 认知表型
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8739321 - 财政年份:2013
- 资助金额:
$ 52.04万 - 项目类别:
White Matter Connectivity and PD Cognitive Phenotypes
白质连接性和 PD 认知表型
- 批准号:
8632312 - 财政年份:2013
- 资助金额:
$ 52.04万 - 项目类别:
Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older Adults
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老年人术后认知能力下降的神经影像生物标志物
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8551727 - 财政年份:2012
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