WHITE MATTER AND COGNITION IN PARKINSON'S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 帕金森氏病--仅在美国就有150多万人患有帕金森氏症；其患病率随着年龄的增长而增加，大多数确诊病例发生在60岁以上。虽然帕金森病主要与静止性震颤和僵硬等运动症状有关，但它也与衰弱的认知症状有关。尽管越来越多的研究表明白质的病理变化可能是退行性疾病的原因，但人们对帕金森病的白质和认知知之甚少。目前的研究将确定：白质完整性对特发性帕金森病的处理速度和工作记忆缺陷的贡献。N=45，相对于年龄和教育程度匹配的对照组，n=45，以及白质对一年后认知变化的预测作用。这个项目将提供关于白质完整性在帕金森病认知功能中的作用的急需的知识。这些信息将有助于我们预测帕金森病患者的认知变化，从而改善帕金森病的治疗决策和干预选择。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Parkinson's Disease-PD affects more than 1.5 million people in the United States alone; its prevalence increases with age, and the majority of the diagnoses occur over age 60. While PD is primarily associated with motor symptoms such as resting tremor and rigidity, it is also associated with debilitating cognitive symptoms. Little is known about whiter matter and cognition in PD despite growing research suggesting pathological changes in the white matter may contribute to the degenerative disease. The present investigation will determine: the contribution of white matter integrity on the processing speed and working memory deficits of idiopathic PD. n=45, relative to that of an age and education matched control group, n=45, and the predictive role of white matter on cognitive change after one year. This project will contribute much needed knowledge about the role of white matter integrity on cognitive function in PD. The information will contribute to our ability to predict cognitive change in PD thereby improving treatment decisions and intervention options for PD.