Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related Dementias

针对阿尔茨海默病和相关痴呆症的围手术期认知麻醉网络 (PeCAN) 计划

• 批准号: 10379966
• 负责人: CATHERINE E PRICE
• 金额: $ 16.2万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10379966
• 关键词: Academic/Teacher Award; Address; Adult; Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Anesthesia procedures; Anesthesiology; Animal Experimentation; Animals; Awareness; Biological Markers; Blood - brain barrier anatomy; Brain; Capsicum; Cardiac; Caring; Case Study; Center for Translational Science Activities; Clinical; Clinical Sciences; Clinical Services; Cognition; Cognitive; Collaborations; Colonoscopy; Communities; Data Science Core; Data Sources; Databases; Delirium; Dementia; Development; Diagnosis; Disease; Education; Elderly; Electroencephalography; Face; Florida; Funding; Grant; Health; Health system; Healthcare; Healthcare Systems; Human; Impaired cognition; Individual; Inflammation; Infrastructure; Institutes; Institution; Intervention; Investigation; Lead; Leadership; Medical; Medicine; Memory; Mentorship; Methods; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Neuropsychology; Operative Surgical Procedures; Outcome; Parkinson Disease; Pathway interactions; Patients; Pecans; Perioperative; Perioperative Care; Persons; Population; Postoperative Period; Procedures; Quality of life; Records; Replacement Arthroplasty; Research; Research Personnel; Research Training; Resources; Retrospective Studies; Risk; Risk Factors; Science; Scientist; Statistical Models; Thick; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vascular Dementia; Ventricular; White Matter Disease; brain behavior; brain health; certificate program; clinical care; cognitive change; cognitive function; cognitive reserve; curriculum development; deep learning; evidence base; human old age (65+); improved; innovation; longitudinal human study; meetings; mild cognitive impairment; mortality; multidisciplinary; nervous system disorder; neuroimaging; neuroimaging marker; non-demented; novel; older patient; postoperative delirium; pre-doctoral; programs; prospective; recruit; research study; screening; success; symposium; trend

ABSTRACT Our healthcare system faces larger numbers of individuals with early to late Alzheimer’s Disease (AD) and other neurodegenerative disorders requiring anesthesia associated procedures for serious health related conditions (e.g., cardiac), screening (e.g., colonoscopy), or quality of life improvement (e.g., joint replacement). Despite evidence that preoperative cognitive status is a risk factor for negative post-operative outcomes, there is a scarcity of research addressing perioperative cognitive-biomarker-anesthesia interactions, and evidence based anesthesia-surgical practices for patients with prodromal or diagnosed dementias. The K07 applicant- an NIH funded independent investigator and board certified neuropsychologist with expertise in the cognitive sequelae and associated neuroimaging markers of AD, vascular dementia, and other neurodegenerative disorders, and cognitive and neuroimaging predictors of perioperative cognitive complications and delirium. The applicant (with support of the institution) is proposing a Perioperative Cognitive Anesthesia Network (PeCAN) Program for AD and related dementia. The purpose– to promote institutional and community awareness of cognition and memory in older adults electing surgical procedures with anesthesia, intensify collaborations on AD biomarkers- anesthesia interactions, and promote translation of research findings to clinical care. The applicant will complete advanced leadership training and three programmatic aims. Aim 1- convene a multidisciplinary advisory team to establish four integrated PeCAN research cores targeting AD and related dementia perioperative research. Cores include a Cognitive-Clinical Core, a Neuroimaging Core, a Biomarker Core, and a Data Science Core. Aim 2- enhance defined and supportive pathways to the PeCAN cores so that early stage investigators can efficiently initiate and complete perioperative-neurodegenerative research. The applicant will integrate pathways between multiple institutional resources including NIH funded 1Florida Alzheimer’s Disease Research Center, Evelyn F. McKnight Brain Institute, the University of Florida (UF) Institute on Aging Pepper Center, and the UF Fixel Center for Neurological Diseases. Aim 3- promote the emergence of highly trained scientists and educators for innovative team science addressing perioperative neuronal risk and mechanisms for protection. Methods will involve implementation of a certificate program, interdisciplinary team-science research opportunities, and pilot funding supported through this grant and institutional matching funds. Trainees will initially include appropriate predoctoral T32 trainees, neuropsychology fellows, and anesthesiology fellows. Milestones- annual analyses of programmatic strengths/weaknesses, multidisciplinary proposal submissions, and evidence of trainee success with perioperative research for AD and related dementias.

抽象的 我们的医疗保健系统面临着大量患有早期至晚期阿尔茨海默病 (AD) 和其他疾病的患者 需要麻醉的神经退行性疾病 与严重健康相关疾病相关的手术 （例如心脏检查）、筛查（例如结肠镜检查）或生活质量改善（例如关节置换）。尽管 有证据表明术前认知状态是术后不良结果的危险因素 缺乏针对围手术期认知-生物标志物-麻醉相互作用的研究，并且基于证据 针对前驱期或确诊痴呆症患者的麻醉手术实践。 K07申请人——NIH 资助独立调查员和委员会认证的神经心理学家，具有认知后遗症方面的专业知识 以及 AD、血管性痴呆和其他神经退行性疾病的相关神经影像标记物，以及 围手术期认知并发症和谵妄的认知和神经影像学预测因素。申请人（与 该机构的支持）正在提议针对 AD 实施围术期认知麻醉网络 (PeCAN) 计划 以及相关的痴呆症。目的——促进机构和社区对认知和记忆的认识 在选择麻醉手术的老年人中，加强 AD 生物标志物方面的合作 麻醉相互作用，并促进研究成果转化为临床护理。申请人将完成 高级领导力培训和三个计划目标。目标 1 - 召集多学科顾问团队 建立四个针对 AD 和相关痴呆症围手术期研究的综合 PeCAN 研究核心。 核心包括认知临床核心、神经影像核心、生物标记核心和数据科学核心。 目标 2 - 增强 PeCAN 核心的明确和支持性途径，以便早期研究人员能够 有效启动并完成围手术期神经退行性研究。申请人将整合途径 多个机构资源之间的合作，包括 NIH 资助的 1 佛罗里达阿尔茨海默病研究中心， 伊芙琳·F·麦克奈特大脑研究所、佛罗里达大学 (UF) 老化胡椒研究所和佛罗里达大学 固定神经疾病中心。目标 3——促进训练有素的科学家和教育工作者的出现 用于解决围手术期神经元风险和保护机制的创新团队科学。方法将 涉及证书计划的实施、跨学科团队科学研究机会和试点 通过这笔赠款和机构配套资金提供资金支持。受训者最初将包括适当的 博士前 T32 实习生、神经心理学研究员和麻醉学研究员。里程碑-年度分析 计划的优势/劣势、提交的多学科提案以及实习生成功的证据 AD 和相关痴呆症的围手术期研究。