"Mount Sinai Regional Drug Induced Liver Injury Network Site"

“西奈山地区药物性肝损伤网络网站”

• 批准号: 8920565
• 负责人: Jawad Ahmad
• 金额: $ 28.71万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8920565
• 关键词: 2 year old; Acute Liver Failure; Adult; African American; Age; Algorithms; Ancillary Study; Antiviral Agents; Area; Asians; Biological Markers; Blood; Blood specimen; Caring; Categories; Child; Clinical; Clinical Data; Collaborations; Complementary and alternative medicine; Computerized Medical Record; DNA; Data; Databases; Diagnosis; Diagnostic; Disease; Early Diagnosis; Electronics; Eligibility Determination; Enrollment; Ensure; Epidemiology; Ethnic group; Etiology; Fatty Liver; Frequencies; Future; General Practitioners; Genomics; Geriatrics; Goals; HIV; HIV Infections; Health; Hematologic Neoplasms; Hepatic; Hepatitis C virus; Hepatology; Hepatotoxicity; Hispanics; Home environment; Human Resources; Immunologic Deficiency Syndromes; Individual; Informed Consent; Infusion procedures; Injury; Injury to Liver; Institutes; Institution; International; Internist; Intervention; Investigation; Lead; Legal Guardians; Liver diseases; Measures; Medical center; Minority; Minority Groups; Molecular; Monitor; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; New York; Oncologist; Outpatients; Parents; Pathogenesis; Patient Monitoring; Patients; Pharmaceutical Preparations; Pilot Projects; Population; Population Control; Preventive; Process; Provider; Qualifying; Reading; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Rights; Risk Factors; Sampling; Serum; Severities; Site; Source; Staging; System; Techniques; Underrepresented Minority; United States National Library of Medicine; Ursidae Family; Writing; acute drug induced liver toxicity; acute liver injury; age group; antiretroviral therapy; base; biobank; case control; chemotherapy; clinical practice; design; dietary supplements; genetic analysis; high risk; improved; innovation; insight; instrument; liver injury; meetings; member; metropolitan; mortality; older patient; patient population; personalized medicine; prevent; programs; prospective; response; screening; success; tertiary care; tool; web site

DESCRIPTION (provided by applicant): Hepatotoxicity due to prescription medications and herbal supplements is increasingly recognized as a major cause of morbidity and mortality throughout the developed world. Due to its idiosyncratic nature, variable presentation, and the vast number of potential causative drugs as well as herbal and dietary supplements, drug-induced liver injury (DILI) is often diagnosed late in its course when patients present with severe liver disease. This makes diagnosis and characterization of the mechanisms involved in the pathogenesis of DILI, difficult and does not allow accurate assessment of the epidemiology and risk factors associated with DILI. Since one of the main concerns with the current DILIN is the late presentation of cases, future investigation should focus on accruing cases where the liver injury is detected early on. The aims of the Mount Sinai membership in the NIDDK DILI study are as follows: 1) To rapidly increase the number of enrolled adults and children with DILI, particularly among under-represented minority groups in the current DILIN prospective and retrospective databases; 2) To enroll patients early in the course of DILI by closely monitoring high risk groups; and 3) ultimately to investigate preventative measures to prevent DILI among high risk groups. The inclusion of Mount Sinai in the DILIN will lead to an increase in the number of DILI cases from Hispanic, Black and Asian patients. The significant number of Asian and Hispanic patients who will be recruited from the New York area may provide insights into the mechanism of liver injury related to the use of herbal and dietary supplements as these populations are known to be frequent users of these complementary and alternative medicines. A major component of the Mount Sinai DILIN will be focused on the recruitment of elderly patients with DILI, and importantly also on a control population taking these supplements, a population not well represented to date in the network. Similarly, Mount Sinai's large population of 4,000 HIV infected patients will provide cases and controls to represent the large population on antiretroviral therapy. The large number of patients undergoing chemotherapy treatment followed by the many Mount Sinai oncologists represents another ideal source of prospective DILI cases and controls. Mount Sinai is a member of eMERGE, a national consortium to develop, disseminate, and apply approaches using electronic medical records (EMR) systems to genomics research. A current projects in eMERGE is to develop an electronic algorithm to identify cases of DILI in EMR systems. If just 1 percent of the 100,000 eMERGE DNA samples have a history of DILI, then the DILIN could double its DNA sample database overnight. Investigators at Mount Sinai are well-qualified and poised to contribute to ancillary studies that arise from the wealth of available data and samples of the collective DILIN. Combined with outstanding infrastructure to collect detailed information through exploitation of the EMR and Data Warehouse, the partnership of the Personalized Medicine program, and involvement of a multi-disciplinary team across the institution and its affiliates, we bring tremendous manpower to bear upon this urgent problem.

描述（由申请人提供）：处方药物和草药补充剂引起的肝毒性越来越被认为是发达国家发病率和死亡率的主要原因。药物性肝损伤（DILI）由于其特殊的性质，多变的表现，以及大量潜在的致病药物以及草药和膳食补充剂，通常在患者出现严重症状时才被诊断出来