Origins of Renal Physiology

肾脏生理学的起源

• 批准号: 8814216
• 负责人: Mark L. Zeidel
• 金额: $ 9.96万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8814216
• 关键词: Address; Animal Model; Biological; Biomedical Research; Bladder; Carrier Proteins; Case Study; Case-Control Studies; Clinical; Clinical Research; Collaborations; Confocal Microscopy; Cultured Cells; DNA Sequence Alteration; Duct (organ) structure; Education; Educational process of instructing; Electrodes; Epithelial; Equilibrium; Faculty; Fees; Foundations; Funding; Future; Genetic; Health; Homeostasis; Human; Human Resources; Instruction; Island; Kidney; Kidney Diseases; Laboratories; Lead; Limb structure; Link; Maine; Medical; Methods; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Outcome; Participant; Physiological; Physiology; Process; Recording of previous events; Renal function; Research; Research Ethics; Research Personnel; Rotation; Running; Salt Gland; Schedule; Services; Shark; Sodium; Sodium Channel; Sodium Chloride; Thick; Touch sensation; Training; Translating; Travel; United States; Urea; Water; Work; Xenopus oocyte; base; career; cost; editorial; epithelial Na+ channel; glomerular filtration; human subject protection; improved; insight; programs; protein structure function; research study; single molecule; toad; tool; trafficking; voltage clamp; water channel; web site

DESCRIPTION (provided by applicant): The Mount Desert Island Biological Laboratory seeks NIDDK R25 support for the fourth through eighth annual offerings of a one-week course for renal fellows, "The Origins of Renal Physiology," at the Mount Desert Island Biological Laboratory (MDIBL), in Bar Harbor, Maine. The course will be held the first week of September 2011 through 2015. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Six course modules are proposed: glomerular filtration, proximal tubule function, thick ascending limb cotransporters, salt secretion and balance, collecting duct sodium transport / ENaC, and water homeostasis. An enrichment module in genetics will be added starting in 2011. Each of the six modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday- Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the six planned modules during the three rotations. A case study-based Responsible Conduct in Research program will precede each rotation. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDIBL website (http://www.mdibl.org), and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, honoraria, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.

描述（由申请人提供）：荒岛山生物实验室寻求NIDDK R25支持，为缅因州巴尔港的荒岛山生物实验室（MDIBL）的肾脏研究员提供为期一周的课程“肾脏生理学的起源”，这是第四到第八届年度课程。该课程将于2011年9月的第一周至2015年举行。本课程为肾脏研究员提供有关体内平衡基本概念的实践研究教育，并使他们接触到构成肾脏生理学和肾脏病学基础的经典实验。六个课程模块：肾小球滤过，近端小管功能，厚升肢共转运蛋白，盐分泌和平衡，收集管钠转运/ ENaC和水稳态。从2011年开始，将增加一个基因富集模块。六个模块中的每一个模块都有三个连续的两天轮转（周一-周二，周三-周四，周五-周六），每个轮转的第一天包括密集的实验工作，第二天包括分析和向整个课程组展示工作。每个参与者将在三个轮岗期间完成六个计划模块中的三个。在每次轮换之前，将有一个基于案例研究的负责任的研究行为计划。《肾脏生理学起源》在全国肾学短期课程中是完全独特的。该课程为参与者提供研究工具，使他们对生理稳态的概念有更深的理解，这在正常的临床训练计划中是很难达到的。该课程对肾脏研究员开放，自2010年起，在可用空间的基础上，对进入肾脏学的住院医师开放。研究员和住院医师都受益于与肾脏生理学高级研究员的密切互动，他们领导了课程模块。住院医生尤其受益于与来自不同项目的研究员合作，分享他们对肾脏研究和肾脏病学的见解。该课程在MDIBL网站（http://www.mdibl.org）和J. Am最近的一篇社论中都有介绍。Soc。《肾脏病学》（Zeidel et al.， JASN）