Origins of Renal Physiology

肾脏生理学的起源

• 批准号: 8814216
• 负责人: Mark L. Zeidel
• 金额: $ 9.96万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8814216
• 关键词: Address; Animal Model; Biological; Biomedical Research; Bladder; Carrier Proteins; Case Study; Case-Control Studies; Clinical; Clinical Research; Collaborations; Confocal Microscopy; Cultured Cells; DNA Sequence Alteration; Duct (organ) structure; Education; Educational process of instructing; Electrodes; Epithelial; Equilibrium; Faculty; Fees; Foundations; Funding; Future; Genetic; Health; Homeostasis; Human; Human Resources; Instruction; Island; Kidney; Kidney Diseases; Laboratories; Lead; Limb structure; Link; Maine; Medical; Methods; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Outcome; Participant; Physiological; Physiology; Process; Recording of previous events; Renal function; Research; Research Ethics; Research Personnel; Rotation; Running; Salt Gland; Schedule; Services; Shark; Sodium; Sodium Channel; Sodium Chloride; Thick; Touch sensation; Training; Translating; Travel; United States; Urea; Water; Work; Xenopus oocyte; base; career; cost; editorial; epithelial Na+ channel; glomerular filtration; human subject protection; improved; insight; programs; protein structure function; research study; single molecule; toad; tool; trafficking; voltage clamp; water channel; web site

DESCRIPTION (provided by applicant): The Mount Desert Island Biological Laboratory seeks NIDDK R25 support for the fourth through eighth annual offerings of a one-week course for renal fellows, "The Origins of Renal Physiology," at the Mount Desert Island Biological Laboratory (MDIBL), in Bar Harbor, Maine. The course will be held the first week of September 2011 through 2015. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Six course modules are proposed: glomerular filtration, proximal tubule function, thick ascending limb cotransporters, salt secretion and balance, collecting duct sodium transport / ENaC, and water homeostasis. An enrichment module in genetics will be added starting in 2011. Each of the six modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday- Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the six planned modules during the three rotations. A case study-based Responsible Conduct in Research program will precede each rotation. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDIBL website (http://www.mdibl.org), and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, honoraria, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.

描述（由申请人提供）：沙漠岛山生物实验室寻求NIDDK R25对肾脏生理学的一周课程的第四至第八届年度课程的支持，“肾脏生理学的起源”，位于Maine Maine Bar Harbour的Mount Destress Destress Island Island Biological Laboratory（MDIBL）。该课程将在2011年9月至2015年的第一周举行。拟议的课程为肾脏研究员提供了动手研究教育，以实现稳态的基本概念，并将其暴露于构成肾脏生理学和肾脏学基础的经典实验中。提出了六个课程模块：肾小球过滤，近端小管功能，较厚的肢体共转运蛋白，盐分泌和平衡，收集导管钠运输 / ENAC和水稳态。从2011年开始，将增加一个遗传学的富集模块。六个模块中的每个模块连续三天（星期一至周日，周三至周四和星期五至周六）连续三个旋转，每次轮换的第一天都涉及大量实验性工作，第二天涉及对整个课程组进行分析和工作的分析和介绍。每个参与者将在三个旋转期间完成六个计划模块中的三个。基于案例研究的研究计划中的负责任行为将在每个旋转之前。肾脏生理学的起源在国家肾脏短期课程中完全是独一无二的。该课程为参与者提供了研究工具，使他们对生理体内平衡的概念有了更深入的了解，这在正常的临床培训时间表中很难获得。该课程向肾脏研究员开放，自2010年以来，在可容纳肾脏病的医疗居民的基础上。研究员和居民都受益于与领导课程模块的肾脏生理学高级研究人员的紧密互动。尤其是居民通过与来自不同计划的研究员合作并分享他们对肾脏研究和肾脏病的见解。该课程在MDIBL网站（http://www.mdibl.org）以及J. Am的最新社论中进行了描述。 Soc。肾脏科学（Zeidel等人，JASN 19：649-50，2008）。要求的资金将涵盖课程学费和参与者旅行；教师生存，酬金和旅行；设施用户费用；顾问服务；管理研究教育计划所需的人员费用。