2014 International Pathogenic Neisseria Conference

2014年国际致病性奈瑟菌会议

• 批准号: 8785926
• 负责人: Ann E. Jerse
• 金额: $ 1.1万
• 依托单位: HENRY M. JACKSON FDN FOR THE ADV MIL/MED
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785926
• 关键词: Address; Animal Model; Antibiotic Resistance; Antigenic Variation; Applied Research; Area; Bacteria; Bacterial Genes; Basic Science; Biology; Blood Circulation; Carrier State; Clinical Research; Communicable Diseases; Developed Countries; Developing Countries; Development; Disease; Disease Outbreaks; Ectopic Pregnancy; Ensure; Equilibrium; Evaluation; Evolution; Frequencies; Future; Generations; Genetic; Genomics; Goals; Gonorrhea; HIV; Health; Incidence; Individual; Infection; Infertility; International; Investigation; Knowledge; Leadership; Limb structure; Measures; Meninges; Meningococcal vaccine; Morbidity - disease rate; Neisseria; Neisseria gonorrhoeae; Neisseria meningitidis; Neonatal; Nervous System Trauma; North Carolina; Oral; Organism; Pathogenesis; Pelvic Inflammatory Disease; Phase; Postdoctoral Fellow; Process; Recruitment Activity; Research; Research Personnel; Role; Scientist; Shock; Students; Survivors; Time; Translational Research; Vaccines; Virulence Factors; Woman; Work; abstracting; deafness; disorder control; gene interaction; gonorrhea vaccine; graduate student; insight; meetings; member; mortality; pathogen; posters; programs; public health relevance; receptor; reproductive; success; symposium; vaccinology

DESCRIPTION (provided by applicant): The XIXth International Pathogenic Neisseria Conference (IPNC) will be held in Asheville, North Carolina from October 12-17th, 2014. The IPNC is a highly regarded and prestigious biennial scientific meeting that is focused on the pathogenesis and control of diseases due to Neisseria meningitidis and Neisseria gonorrhoeae. These Neisseria species rank high among medically significant pathogens due to the unacceptable incidence of meningococcal disease and gonorrhea and associated morbidity and mortality world-wide. These pathogens are also model organisms for studying horizontal genetic exchange, adaptation to the host through high frequency phase and antigenic variation of bacterial genes, interactions with innate receptors, evolution of host-restricted virulence factors and mechanisms by which bacteria can act as either a commensal organism (e.g. the meningococcal carrier state, inapparent gonococcal infections) or a frank pathogen. Historically, the focus of the IPNC has been on basic scientific and applied research rather than clinical research. The objectives of the 2014 IPNC are to: i.) Organize a conference that is well balanced with respect to basic and translational research and that gives equal emphasis to research on Neisseria meningitidis and Neisseria gonorrhoeae; ii.) Highlight cutting edge research and areas of research need by conducting a rigorous review of abstracts for oral presentation and by organizing roundtable discussion groups to stimulate new areas of investigation; and iii.) Create a dynamic and interactive setting that facilitates interactions between established and junior researchers to ensure the future of this important field. To meet these objectives, abstracts will be solicited in nine research areas that we have identified as critical for increasing knowledge about the pathogenesis of these organisms and for the eventual control of disease. A rigorous evaluation process will be used to select the highest quality abstracts for oral presentation; remaining acceptable abstracts will be presented as posters at evening sessions. Several new investigators will be included among session moderators, and posters presented by student and postdoctoral fellows will be judged by both senior and junior scientists to increase interactions between scientific generations. Four round table discussion groups have been organized that address new research areas, and one or two vaccinology symposia will be held to discuss the on-going characterization of the newly developed group B meningococcal vaccines, which continues to be a highly significant and exciting research area within the Neisseria field.

描述（由申请人提供）：第十九届国际致病性奈瑟氏球菌会议（IPNC）将于2014年10月12日至17日在北卡罗来纳州阿什维尔举行。IPNC是一个高度重视和享有盛誉的两年一度的科学会议，重点是脑膜炎奈瑟菌和淋病奈瑟菌引起的疾病的发病机制和控制。由于脑膜炎球菌病和淋病的不可接受的发病率以及世界范围内的相关发病率和死亡率，这些奈瑟菌属物种在医学上重要的病原体中排名很高。这些病原体也是研究水平遗传交换、通过细菌基因的高频阶段和抗原变异适应宿主、与先天受体的相互作用、宿主限制性毒力因子的进化以及细菌作为寄生生物（例如脑膜炎球菌携带状态、隐性淋球菌感染）或直接病原体的机制的模式生物。历史上，IPNC的重点一直是基础科学和应用研究，而不是临床研究。2014年IPNC的目标是：组织一次会议，在基础研究和转化研究方面保持平衡，并同等重视脑膜炎奈瑟菌和淋病奈瑟菌的研究; ii.）通过对口头报告的摘要进行严格审查，并通过组织圆桌讨论小组来激发新的研究领域，突出前沿研究和研究需求领域; iii.）创建一个动态和互动的环境，促进建立和初级研究人员之间的互动，以确保这一重要领域的未来。为了实现这些目标，将在九个研究领域征集摘要，我们已经确定这些研究领域对于增加有关这些生物体的发病机制和最终控制疾病的知识至关重要。将采用严格的评价程序，选择最高质量的摘要进行口头介绍;其余可接受的摘要将在晚间会议上以海报形式展示。会议主持人中将包括几名新的研究人员，学生和博士后研究员提交的海报将由高级和初级科学家进行评判，以增加科学世代之间的互动。已经组织了四个圆桌讨论小组，讨论新的研究领域，还将举行一个或两个疫苗学专题讨论会，讨论新开发的B组脑膜炎球菌疫苗的持续特性，这仍然是奈瑟菌领域内一个非常重要和令人兴奋的研究领域。