The Gonorrhea Vaccine Cooperative Research Center
淋病疫苗合作研究中心
基本信息
- 批准号:10588233
- 负责人:
- 金额:$ 213.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-26 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAnimalsAntibiotic ResistanceAntibodiesAntigensClinical TrialsCollaborationsCommunicationConserved SequenceEnsureEpitopesEvaluationFemaleFosteringGoalsGonorrheaHumanImmunizeImmunology procedureIndividualInfectionInfrastructureInstitutionModelingMusNational Institute of Allergy and Infectious DiseasePeer ReviewPreparationProcessProtein SubunitsPublic HealthResearchResearch Project GrantsSafetySamplingSubunit VaccinesSurfaceTeleconferencesUnited States National Institutes of HealthVaccinatedVaccinesVirus-like particleWorkbactericidedata exchangegonorrhea vaccinein vivomanufacturabilitymeetingsmouse modelnanodiskpreclinical developmentpreventprogramsreproductive tractvaccine candidatevaccine developmentvaccine platformvaccine-induced immunity
项目摘要
ABSTRACT
The overall goal of the Gonorrhea Vaccine Cooperative Research Center (GV CRC) is to advance promising
vaccine candidates towards further preclinical development and clinical trials. The proposed GV CRC is
organized around four Research Projects, which collectively will address the large research gap regarding
correlates of vaccine-induced immunity against gonorrhea using human samples from individuals and mice
vaccinated with the 4CMenB vaccine for which there is evidence of protection against gonorrhea (Project 1) and
develop candidate gonorrhea vaccines against promising Ng surface molecules using vaccine platforms with
proven safety and manufacturability, specifically OMV vaccines (Project 2), nanodisc-displayed protein subunit
vaccines (Project 3) and epitope-tagged virus-like particle vaccines (Project 4). The choice of vaccine targets is
based on sequence conservation, capacity to induce bactericidal antibodies (Abs), in vivo efficacy in the mouse
model, and, or recognition by Abs from mice immunized with 4CMenB, which accelerates Ng clearance in the
female mouse model of lower genital tract infection. Vaccine immunogens will be prepared by a centralized core
(Core B) to ensure consistent and controlled preparations, and all vaccine candidates will be subjected to a
systematic and rigorous evaluation process that uses state-of-the-art immunological assays (Cores C and D)
and animal infection models (Core E) through the participation of four centralized Scientific Cores. An
Administrative Core (Core A) will provide the infrastructure needed to facilitate communications between the
different institutions within the center and with NIH/NIAID program staff, and coordinate teleconferences and
meetings among the Project and Core leaders to foster data exchange, internal peer review and collaboration.
A standing outside Scientific Advisory Board will review scientific progress in years 2 and 4, and determine which
vaccines will be advanced for further pre-clinical development.
摘要
淋病疫苗合作研究中心(GV CRC)的总体目标是推进有前景的
候选疫苗的进一步临床前开发和临床试验。拟议的GV CRC是
围绕四个研究项目组织,这些项目将共同解决以下方面的巨大研究差距:
使用来自个体和小鼠的人类样本的疫苗诱导的抗淋病免疫的相关性
接种了有证据表明可预防淋病的4CMenB疫苗(项目1),以及
使用疫苗平台开发针对有希望的Ng表面分子的候选淋病疫苗,
已证实的安全性和可制造性,特别是OMV疫苗(项目2),纳米盘展示的蛋白亚基
疫苗(项目3)和表位标记的病毒样颗粒疫苗(项目4)。疫苗靶点的选择是
基于序列保守性、诱导杀菌抗体(Abs)的能力、小鼠体内功效
模型,和/或来自用4CMenB免疫的小鼠的Ab的识别,这加速了Ng在细胞中的清除。
下生殖道感染的雌性小鼠模型。疫苗免疫原将由一个集中的核心
(Core B)确保一致和受控的制备,所有候选疫苗将接受
采用最先进的免疫学检测(核心C和D)的系统和严格的评价过程
和动物感染模型(核心E)通过四个集中的科学核心的参与。一个
行政核心(核心A)将提供必要的基础设施,以促进
中心内的不同机构和NIH/NIAID计划工作人员,并协调电话会议,
项目和核心领导人之间的会议,以促进数据交换,内部同行评审和协作。
一个常设的外部科学顾问委员会将审查第2年和第4年的科学进展,并确定
疫苗将进一步推进临床前开发。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ann E. Jerse其他文献
Gonococcal PorB: a multifaceted modulator of host immune responses
淋球菌孔蛋白B:宿主免疫反应的多面调节因子
- DOI:
10.1016/j.tim.2023.10.002 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:14.900
- 作者:
Rebekah A. Jones;Ann E. Jerse;Christoph M. Tang - 通讯作者:
Christoph M. Tang
emNeisseria gonorrhoeae/em Coinfection during emChlamydia muridarum/em Genital Latency Does Not Modulate Murine Vaginal Bacterial Shedding
淋病奈瑟菌/鼠衣原体生殖器潜伏期间的合并感染不会调节小鼠阴道细菌脱落
- DOI:
10.1128/spectrum.04500-22 - 发表时间:
2023-05-18 - 期刊:
- 影响因子:3.800
- 作者:
Delia Onorini;Cory Ann Leonard;Regenia Phillips Campbell;Barbara Prähauser;Theresa Pesch;Robert V. Schoborg;Ann E. Jerse;Bernadetta Tarigan;Nicole Borel - 通讯作者:
Nicole Borel
Ann E. Jerse的其他文献
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{{ truncateString('Ann E. Jerse', 18)}}的其他基金
The Gonorrhea Vaccine Cooperative Research Center
淋病疫苗合作研究中心
- 批准号:
9900718 - 财政年份:2019
- 资助金额:
$ 213.85万 - 项目类别:
The Gonorrhea Vaccine Cooperative Research Center
淋病疫苗合作研究中心
- 批准号:
10362587 - 财政年份:2019
- 资助金额:
$ 213.85万 - 项目类别:
Continuing Preclinical Development of PPCM Vaginal Contraceptive MPT to IND
PPCM 阴道避孕药 MPT 至 IND 的持续临床前开发
- 批准号:
9889971 - 财政年份:2017
- 资助金额:
$ 213.85万 - 项目类别:
The Atlantic Coast Sexually Transmitted Infection Cooperative Research Center (AC
大西洋海岸性传播感染合作研究中心(AC
- 批准号:
9316484 - 财政年份:2014
- 资助金额:
$ 213.85万 - 项目类别:
The Atlantic Coast Sexually Transmitted Infection Cooperative Research Center (AC
大西洋海岸性传播感染合作研究中心(AC
- 批准号:
8769562 - 财政年份:2014
- 资助金额:
$ 213.85万 - 项目类别:
2014 International Pathogenic Neisseria Conference
2014年国际致病性奈瑟菌会议
- 批准号:
8785926 - 财政年份:2014
- 资助金额:
$ 213.85万 - 项目类别:
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