Clinically Translatable Cardiac Diffusion MR for Non-Contrast Characterization of

临床可转化心脏弥散 MR 用于非对比表征

基本信息

  • 批准号:
    8784942
  • 负责人:
  • 金额:
    $ 2.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-08 至 2015-06-15
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The long-term objective is to develop an innovative and clinically robust cardiac diffusion MRI sequence that is sensitive to changes to myocardial tissue microstructure. The ability to characterize myocardial tissue microstructure will allow for unique insight to the pathophysiological progression of cardiovascular diseases (CVD) such as acute coronary syndrome, myocarditis, and cardiomyopathy, which are among the leading causes of morbidity and mortality of the US. Conventional cardiac MRI (CMR) techniques have shown to be clinically valuable in revealing morphological changes in the myocardium while providing excellent soft tissue contrast. However, validated CMR techniques used for myocardial tissue characterization require the use contrast agents. For patients with compromised renal systems such as those with Chronic Kidney Disease (CKD), these patients cannot benefit from these contrast-based techniques. Furthermore, 25% of CKD patients have a severe form of CVD that results in left ventricular hypertrophy (LVH) and can directly benefit from characterization of myocardial tissue fibrosis. Therefore, there is a need for a novel MR technique capable of non- contrast quantification of myocardial fibrosis, which we believe can be achieved with cardiac diffusion MRI. In this proposed project, a clinically translatable cardiac diffusion MR technique capable of myocardial fibrosis characterization of the human myocardium will be applied in hypertrophic cardiomyopathy patients (HCM) who are known to have high degree of fibrosis validated with contrast-enhanced CMR. Specific Aim 1 addresses the technical challenges of the clinical translation of a newly established cardiac diffusion MR technique developed by our lab, which requires better spatial coverage, spatial resolution, and shorter scan times. Specific Aim 2 will apply the proposed technique developed in Specific Aim 1 to HCM patients to characterize the extent of myocardial fibrosis and compare it with validated contrast-enhanced CMR methods. Hypothesis: Clinical translation of cardiac diffusion MRI requires major technical innovation, and a key application to demonstrate the technique's clinical utility for CKD+LVH patients would be to characterize myocardial fibrosis in HCM patients without the use of contrast agents.
描述(由申请人提供):长期目标是开发一种创新的、临床上稳健的心脏弥散MRI序列,该序列对心肌组织微结构的变化敏感。表征心肌组织微观结构的能力将允许对心血管疾病(CVD)的病理生理学进展的独特见解,例如急性冠状动脉综合征、心肌炎和心肌病,这些疾病是美国发病率和死亡率的主要原因之一。传统的心脏MRI(CMR)技术已被证明是临床上有价值的,揭示心肌的形态学变化,同时提供良好的软组织对比。然而,用于心肌组织定征的经验证CMR技术需要使用造影剂。对于肾系统受损的患者,如慢性肾病(CKD)患者,这些患者无法从这些基于造影剂的技术中获益。此外,25%的CKD患者患有严重的CVD,导致左心室肥大(LVH),并可直接受益于心肌组织纤维化的表征。因此,需要一种能够对心肌纤维化进行非对比定量的新型MR技术,我们相信心脏弥散MRI可以实现这一点。在这个拟议的项目中,一个临床上可翻译的心脏 能够对人类心肌进行心肌纤维化表征的扩散MR技术将应用于已知具有经对比增强CMR验证的高度纤维化的肥厚型心肌病患者(HCM)。具体目标1解决了我们实验室开发的新建立的心脏弥散MR技术的临床转化的技术挑战,该技术需要更好的空间覆盖范围,空间分辨率和更短的扫描时间。具体目标2将具体目标1中开发的拟议技术应用于HCM患者,以表征心肌纤维化的程度,并将其与经验证的对比增强CMR方法进行比较。假设:心脏弥散MRI的临床转化需要重大的技术创新,证明该技术对CKD+LVH患者的临床实用性的关键应用是在不使用造影剂的情况下表征HCM患者的心肌纤维化。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prospective Pilot Trial to Evaluate a High Resolution Diffusion-Weighted MRI in Prostate Cancer Patients.
  • DOI:
    10.1016/j.ebiom.2016.03.041
  • 发表时间:
    2016-05
  • 期刊:
  • 影响因子:
    11.1
  • 作者:
    Sharif-Afshar AR;Nguyen C;Feng TS;Payor L;Fan Z;Saouaf R;Li D;Kim HL
  • 通讯作者:
    Kim HL
Contrast-free detection of myocardial fibrosis in hypertrophic cardiomyopathy patients with diffusion-weighted cardiovascular magnetic resonance.
弥散加权心血管磁共振无造影剂检测肥厚型心肌病患者心肌纤维化
In vivo diffusion-tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion compensated diffusion-preparation approach.
  • DOI:
    10.1002/mrm.26380
  • 发表时间:
    2016-11
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Nguyen, Christopher;Fan, Zhaoyang;Xie, Yibin;Pang, Jianing;Speier, Peter;Bi, Xiaoming;Kobashigawa, Jon;Li, Debiao
  • 通讯作者:
    Li, Debiao
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Christopher T Nguyen其他文献

Pressure gradient measurement using phase contrast (PC)-MRI in stenotic phantom models: Towards noninvasive quantification of fractional flow reserve in the coronary arteries
  • DOI:
    10.1186/1532-429x-18-s1-w15
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Zixin Deng;Sang Eun Lee;Zhaoyang Fan;Christopher T Nguyen;Qi Yang;Xiaoming Bi;Byoung Wook Choi;Daniel S Berman;Hyuk-Jae Chang;Debiao Li
  • 通讯作者:
    Debiao Li
In vivo cardiac DTI on a widely available 3T clinical scanner: an optimized M2 approach
  • DOI:
    10.1186/1532-429x-18-s1-o18
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Christopher T Nguyen;Zhaoyang Fan;Yibin Xie;Jianing Pang;Xiaoming Bi;Peter Speier;Jon Kobashigawa;Debiao Li
  • 通讯作者:
    Debiao Li
Optimized cardiac CEST MRI for assessment of metabolic activity in the heart
  • DOI:
    10.1186/1532-429x-18-s1-o70
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Zhengwei Zhou;Yuhua Chen;Yibin Xie;Christopher T Nguyen;Mu Zeng;James Dawkins;Zhanming Fan;Eduardo Marbán;Debiao Li
  • 通讯作者:
    Debiao Li
Fully automated left ventricle function analysis with self-gated 4D MRI
  • DOI:
    10.1186/1532-429x-18-s1-p37
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Yuhua Chen;Jianing Pang;David Neiman;Yibin Xie;Christopher T Nguyen;Zhengwei Zhou;Debiao Li
  • 通讯作者:
    Debiao Li
Pressure gradient measurement in the coronary artery using phase contrast (PC)-MRI: initial patient results towards noninvasive quantification of fractional flow reserve
  • DOI:
    10.1186/1532-429x-18-s1-p218
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Zixin Deng;Sang Eun Lee;Zhaoyang Fan;Christopher T Nguyen;Qi Yang;Xiaoming Bi;Byoung Wook Choi;Daniel S Berman;Hyuk-Jae Chang;Debiao Li
  • 通讯作者:
    Debiao Li

Christopher T Nguyen的其他文献

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{{ truncateString('Christopher T Nguyen', 18)}}的其他基金

Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI
使用心脏扩散张量 MRI 连续评估运动训练对心力衰竭的心脏保护作用
  • 批准号:
    10672834
  • 财政年份:
    2022
  • 资助金额:
    $ 2.85万
  • 项目类别:
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI
使用心脏扩散张量 MRI 连续评估运动训练对心力衰竭的心脏保护作用
  • 批准号:
    10626751
  • 财政年份:
    2022
  • 资助金额:
    $ 2.85万
  • 项目类别:
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI
使用心脏扩散张量 MRI 连续评估运动训练对心力衰竭的心脏保护作用
  • 批准号:
    10214689
  • 财政年份:
    2020
  • 资助金额:
    $ 2.85万
  • 项目类别:
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI
使用心脏扩散张量 MRI 连续评估运动训练对心力衰竭的心脏保护作用
  • 批准号:
    10417208
  • 财政年份:
    2020
  • 资助金额:
    $ 2.85万
  • 项目类别:

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