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Chronically-Implantable Multisite Microelectrode Arrays

长期植入多部位微电极阵列

基本信息

批准号：
8955640
负责人：
Martin Han
金额：
$ 42.1万
依托单位：
HUNTINGTON MEDICAL RESEARCH INSTITUTES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-15 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8955640
关键词：
Animal Model Auditory Brain Brain Stem Cerebral cortex Chronic Clinical Cochlear Implants Custom Data Deep Brain Stimulation Development Devices Disease Electrodes Environmental Wind Failure Feedback Felis catus Flowcharts Funding Future Generations Implant In Vitro Individual Lead Masks Measurement Mechanics Medical Device Microelectrodes Motor Neurons Neurophysiology - biologic function Neurosciences Ocular Prosthesis Parkinson Disease Process Rattus Research Personnel Resources Shipping Ships Silicon Silicones Spinal Cord Spinal nerve structure Structure Suggestion Symptoms Testing Tissues Translations Vendor Work base brain machine interface clinical application design electrical property experience flexibility hearing impairment implantable device implantation in vivo meetings microstimulation multi-electrode arrays nervous system disorder neural prosthesis neural stimulation neuroregulation nonhuman primate premature public health relevance tool

项目摘要

DESCRIPTION (provided by applicant): We are requesting funding for an essential need in neuroscience, supporting researchers with chronically-implantable multisite microelectrode arrays. Microelectrode arrays are an important tool for neural prostheses and brain machine interfaces as well as for basic neuroscience. Clinical applications now under development include central auditory prostheses that utilize electrical neural stimulation to overcome hearing loss, visual prostheses employing microstimulation in the cerebral cortex, and closed-loop deep brain stimulation to relieve the motor symptoms of Parkinson's disease and other disorders. While there are commercial vendors providing microwire arrays and silicon arrays suitable for chronic implantation, there is an unmet need for custom-assembled silicon-based 3D multisite microelectrode arrays. This resource center will design, fabricate, and assemble customized microelectrode arrays for long-term neural stimulation and recording in-vivo. The proposed devices will be fabricated from custom-designed multisite silicon-based arrays that can be inserted into targets in the sulci of the cerebral cortex, deep brain, brainstems, and spinal cord or spinal nerves. The devices will be mechanically sturdy for reliable insertion into the target tissues, and will have long flexible cables to meet users' requirements. The arrays are intended to be used in animal models such as rats, cats, and non-human primates, and are designed to facilitate clinical translation.