Automated Assessment of Leptomeningeal Collaterals on CT Angiograms

CT 血管造影上软脑膜循环的自动评估

• 批准号: 8905209
• 负责人: STEPHEN R AYLWARD
• 金额: $ 15万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8905209
• 关键词: Academia; Achievement; Address; Algorithms; Angiography; Award; Blood Pressure; Blood Vessels; Blood flow; Brain; Businesses; Clinical; Clinical Data; Computer software; Consult; Contracts; Development; Doctor of Medicine; Doctor of Philosophy; Effectiveness; Evaluation; Funding; Goals; Gold; Human; Hypertension; Image; Image Analysis; Industry; Intervention; Intraobserver Variability; Koreans; Literature; Malignant Neoplasms; Manuals; Measurement; Medical Imaging; Methods; Morphology; Odds Ratio; Operative Surgical Procedures; Outcome; Patients; Phase; Play; Publishing; Radiation; Recurrence; Registries; Research; Retrospective Studies; Risk; Role; Scientist; Site; Slice; Small Business Innovation Research Grant; Solutions; Stream; Stroke; System; Techniques; Testing; Thrombolytic Therapy; Tissues; Treatment Efficacy; United States National Institutes of Health; Universities; Venous; Work; X-Ray Computed Tomography; acute stroke; base; commercialization; density; digital; image guided; innovation; open source; phase 2 study; post stroke; public health relevance; research clinical testing; tool; tumor

 DESCRIPTION (provided by applicant): The primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiography (CTA) as a quantitative assessment of acute stroke. Leptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal occlusion. The presence and effectiveness of leptomeningeal collaterals (i.e., "collateral status") will vary significantly from patient to patint. Collateral status has been shown to be correlated with both patient outcome and risk of hemorrhagic transformation, suggesting that rapid and accurate assessment of the collaterals would provide a powerful tool for treatment evaluation. The current gold standard for collateral scoring is performed by subjective analysis of retrograde filling in invasive digital subtraction angiograms (DSA). Though CTA is more limited than DSA in the direct evaluation of collaterals, the presence of collaterals may also be evaluated in CTA by the degree of vessel filling beyond the site of occlusion. Several manual assessment techniques based on CTA have been proposed in the literature, but all are subjective and require significant human intervention. Thus, we propose to develop an automated CTA-based collateral status assessment. The aims of our work are as follows: 1) adapt our vessel segmentation algorithms to collateral vessel assessment, 2) perform retrospective evaluation of the CTA derived collateral measurements against DSA in patients, and 3) conduct preliminary retrospective clinical evaluation of the CTA derived collateral measurements against patient outcome. This work brings together a strong yet diverse team, addresses a significant clinical problem with an innovative solution, and uses a two-pronged approach to commercialization involving protected IP and an open-source platform that promotes consulting revenue.

 描述（由适用提供）：这项研究的主要目标是基于CT血管造影（CTA）开发自动评分系统，作为急性中风的定量评估。在近端阻塞的情况下，瘦脑cal虫为血流提供了替代路径。在患者之间，瘦脑副膜的存在和有效性（即“附带地位”）将有很大差异。附带状态已被证明与患者结局和出血转化的风险相关，这表明对抵押品的快速和准确评估将为治疗评估提供强大的工具。当前的抵押评分金标准是通过对侵入性数字减法血管造影（DSA）中逆行填充的对象分析进行的。尽管在直接评估抵押品时，CTA比DSA更有限，但在CTA中也可以通过在闭塞部位以外的血管填充程度评估侧支的存在。文献中已经提出了基于CTA的几种手动评估技术，但所有手动评估技术都是主观的，需要大量的人类干预。这，我们建议开发自动化的基于CTA的抵押状态评估。我们工作的目的如下：1）使我们的血管分割算法适应抵押船舶评估，2）对CTA派生的侧支测量对DSA的回顾性评估，对患者进行DSA，3）3）进行了对CTA衍生的衍生性临床评估，对CTA衍生的临床评估对患者的抵押品抗体测量。这项工作汇集了一个强大但潜水员的团队，通过创新解决方案解决了一个重大的临床问题，并使用两管齐下的商业化方法涉及保护IP和一个开源平台，以促进咨询收入。