Photonic Nanosonophores for Functional and Structural Imaging

用于功能和结构成像的光子纳米声载体

• 批准号: 8830441
• 负责人: Raoul Kopelman
• 金额: $ 31.69万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-02 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8830441
• 关键词: 3-Dimensional; Affect; Animal Model; Attention; Biocompatible; Biological; Chemical Structure; Chemicals; Contrast Media; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Drug Delivery Systems; Early Diagnosis; Effectiveness; Evaluation; Free Will; Functional Imaging; Functional disorder; Generations; Gold; Health; Healthcare; Hydrogels; Hypoxia; Image; Imaging Techniques; Imaging technology; Inflammatory Arthritis; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of ovary; Malignant neoplasm of prostate; Maps; Methods; Molecular; Monitor; Morphology; Onset of illness; Oxygen; PUVA Photochemotherapy; Pharmaceutical Preparations; Positron-Emission Tomography; Process; Radiation therapy; Resistance; Series; Severity of illness; Staging; Structure; Therapeutic; Therapeutic Effect; Time; Tissues; Tumor Tissue; Ultrasonography; accurate diagnosis; acoustic imaging; base; cancer imaging; chemobrain; chemotherapy; cost; imaging modality; in vivo; individualized medicine; insight; malignant breast neoplasm; melanoma; nanodiagnostic; nanoparticle; optical imaging; photoacoustic imaging; photonics; response; sensor; temporal measurement; tumor; tumor growth; tumor progression

DESCRIPTION (provided by applicant): Proposed is the combining of tumor-targeted, biocompatible, contrast enabling nanoparticles with photoacoustic imaging (PAI). PAI is an emerging, simple, low cost, non-ionizing and non-invasive method. The aim of this combination is to achieve simultaneous structural and chemical/functional imaging. Recently, the emerging PAI technique has drawn considerable attention and has been explored for its potential application to a variety of diseases, including breast cancer, prostate cancer, melanoma and inflammatory arthritis. The proposed nanosonophore-based PAI method enables safe imaging, using only light and ultrasound, together with biocompatible, hydrogel-based, biodegradable and bio-eliminable nanoparticle contrast agents and sensors. The resultant non-invasive and non-ionizing PAI will enable morphological and functional evaluation, across the tumor, with both high spatial and high temporal resolution, but without any damage to the tissues. Currently no gold standard exists for such functional imaging. The proposed imaging method can be used for early detection and diagnosis of tumors, and for monitoring the progression of disease and of therapy. It could also observe phenomena at the molecular level in vivo and allow a better understanding of the pathophysiology of diseases as well as of disease onset, progression, and response to therapy. Using a nanoparticle contrast agent that enables multiple chemical and structural imaging functions, simultaneously, will free healthcare practitioners from having to perform a series of examinations with a diverse set of contrast agents so as to generate a complete diagnostic assessment. The Specific Aims are: 1. Optimization of Targeted Multi-functional Sonophoric Nanoparticles (NPs) as Contrast Agents for in-vivo Structural and Functional Photoacoustic Imaging. 2. Structural Imaging using Nanoparticles Targeted at the Tumor 3. Functional Imaging of the In-Vivo Distribution of Oxygen and pH Across Tumors. 4. Monitoring Tumor Therapy by a Combination of Structural and Functional Imaging.

描述（由申请人提供）：提出的是结合以肿瘤为生的，生物相容性，对比度，使纳米颗粒具有光声成像（PAI）。 PAI是一种新兴，简单，低成本，非离子化和非侵入性方法。这种组合的目的是实现同时结构和化学/功能成像。最近，新兴的PAI技术引起了广泛的关注，并因其在各种疾病中的潜在应用，包括乳腺癌，前列腺癌，黑色素瘤和炎性关节炎而受到探索。提出的基于纳米气成液的PAI方法仅使用轻度和超声，以及生物相容性，基于水凝胶的，可生物降解和生物溶解的纳米粒子对比剂和传感器。所得的非侵入性和非电源PAI将在整个肿瘤中实现形态学和功能评估，并具有高空间和高时间分辨率，但对组织没有任何损害。目前，这种功能成像尚无金牌标准。所提出的成像方法可用于早期检测和诊断肿瘤，并监测疾病和治疗的进展。它还可以在体内观察到分子水平的现象，并可以更好地了解疾病的病理生理以及疾病发作，进展和对治疗的反应。使用纳米颗粒对比剂，同时可以使医疗保健从业人员不得不进行一系列具有多种对比剂的检查，以产生完整的诊断评估。具体目的是：1。对目标多功能超声纳米颗粒（NP）的优化，作为体内结构和功能光声成像的对比剂。 2。使用针对肿瘤3的纳米颗粒的结构成像。氧气和pH跨肿瘤的体内分布的功能成像。 4。通过结构和功能成像的结合来监测肿瘤疗法。