Prisms Informatics Platform - Federated Integration Architecture

哮喘是美国最常见的儿科慢性疾病，与重要的医疗保健相关 负担尽管治疗取得了进展，但儿童哮喘控制仍然普遍较差。控制不佳是 与生理和行为因素以及环境暴露有关。虽然研究 人们一直致力于研究生理和行为因素对哮喘的影响， 环境暴露对哮喘儿童的影响有限。传感器的最新进展 技术提供了测量环境暴露和改善哮喘研究的新方法。但是，在这方面， 在研究中使用传感器数据的情况仍然不多见，而且存在多种障碍。传感器数据很复杂， 传感器之间的结构可变，高容量和高频率采集（例如，每分钟或 更多）和多维，传感器数据链接到地理空间位置，时间和描述 暴露。此外，传感器缺乏环境暴露的数据收集和数据交换标准， 缺乏共同的数据元素，家庭接口不足，缺乏安全的通信 数据传输的方式。此外，几乎没有努力将传感器数据与临床数据相结合。 这使得研究环境对哮喘的实际影响变得困难。拟议的PRISMS - Informatics Federation Architecture Center提供基于标准的开放访问架构， 传感器数据沿着临床数据的采集、集成和管理的标准化流程 从哮喘症状、生活质量、卫生保健使用和其他哮喘的纵向评估， 相关的成果指标。具体来说，我们建议开发三个协同且紧密集成的项目 项目1：发展基础设施， 软件，以方便数据采集和信息交流。我们将为移动的应用程序开发一个平台， 支持从孩子的家居和环境传感器中提取数据，并对数据进行友好处理 用于向参与者展示数据的界面。项目2：开发高分辨率数据集成 平台将提供通用核心，允许传感器数据与临床数据集成，以及 安全地将数据传输到PRISMS数据协调中心的机制。该项目将利用 现有的OpenFurther架构，开源框架，促进代码的可重用性和互操作性。 项目3：为研究人员开发一个具有灵活用户界面的平台，以配置各种实验 的设计.我们将使用以用户为中心的设计来开发用户和研究人员界面。这些项目 紧密集成，由项目2中的架构连接。总体而言，这些项目将使数据收集标准化 从环境的各种传感器，与临床数据和演示数据集成，以加强研究， 提高我们对环境暴露对哮喘儿童影响的认识。

Asthma is the most common pediatric chronic illness in the US and associated with significant health care burden. Despite advances in treatment, asthma control in children remains generally poor. Poor control is associated with physiological and behavioral factors as well as with environmental exposures. While research efforts have been devoted to studying the impact of physiological and behavioral factors on asthma, research on the effects of environmental exposures in children with asthma is limited. Recent advances in sensor technologies offer new ways to measure environmental exposures and improve asthma research. However, use of sensor data in research remains uncommon and multiple barriers exist. Sensor data are complex, being variable in structure from sensor to sensor, high volume and acquired at a high frequency (e.g. every minute or more), and multi-dimensional, with sensor data linked to geo-spatial location, time, and description of exposures. Further, sensors lack standards for data collection and data exchange of environmental exposures, lack common data elements, have inadequate interfaces for families, and lack of secure communication modalities for data transmission. Moreover, little effort has been made to integrate sensor data with clinical data, making it difficult to study the actual effects of the environment on asthma. The proposed PRISMS – Informatics Federation Architecture Center provides standard-based, open access architecture and standardized processes for acquisition, integration, and management of sensor data, along with clinical data from longitudinal assessments of asthma symptoms, quality of life, health care usage, and other asthma related outcome metrics. Specifically, we propose to develop three synergistic and tightly integrated projects that make up an innovative sensor monitoring system, including: Project 1: Develop infrastructure and software to facilitate data acquisition and information exchange. We will develop a platform for mobile apps to support data extraction from the child’s home and environment sensors, and data processing and user-friendly interface for data presentation to the participants. Project 2: Develop a high-resolution data integration platform that will provide the common core, allowing sensor data to be integrated with clinical data, and mechanisms for securely transmitting data to the PRISMS data coordinating center. This project will leverage existing OpenFurther architecture, open source frameworks that promote code reusability and interoperability. Project 3: Develop a platform for researchers with flexible user interface to configure a variety of experimental designs. We will use user-centered design to develop both user and researcher interfaces. These projects are tightly integrated, linked by the architecture in project 2. Overall, these projects will standardize data collection from environmental various sensors, data integration with clinical data and presentation to enhance research to improve our knowledge of the impact of environmental exposures on children with asthma.