The Role of Aging in the Progression of Tendon Degeneration Due to Compressive Mechanical Overload: A Multiscale Approach

衰老在压缩机械过载引起的肌腱退变进展中的作用：多尺度方法

• 批准号: 9047918
• 负责人: Brianne Kathryn Connizzo
• 金额: $ 5.07万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9047918
• 关键词: Affect; Age; Aging; Animal Model; Balance training; Basic Science; Biological Models; Biomechanics; Biomedical Engineering; Cell Death; Cell physiology; Cells; Clinical Research; Diagnosis; Disease; Disease Progression; Early treatment; Economic Burden; Environment; Exercise; Fibrocartilages; Future; Gene Proteins; Goals; Health; Histology; Impairment; Incidence; Inflammation; Injury; Lead; Mechanics; Motion; Mus; Orthopedics; Pain; Pathogenesis; Pathology; Phenotype; Population; Posture; Process; Property; Proteoglycan; Protocols documentation; Quality of life; Regimen; Rehabilitation therapy; Relative (related person); Reporting; Research; Research Personnel; Research Training; Role; Rotator Cuff; Shoulder Pain; Site; Staging; System; Tendon structure; Therapeutic; Tissue Engineering; Tissues; Training; Training Activity; Work; age effect; age group; age related; aged; aging population; base; career development; cost; design; disability; experience; fluid flow; in vivo; insight; joint function; multi-scale modeling; musculoskeletal injury; nanomechanics; normal aging; novel; programs; protein expression; public health relevance; repaired; response; skills; stem

 DESCRIPTION (provided by applicant): The objective of this proposal is to provide the applicant with exemplary research training in orthopedic bioengineering. To achieve this objective, a training regimen has been developed, consisting of research aims and substantial training activities. Degenerative rotator cuff disease affects greater than 50% of the aged population, leading to serious impairment of joint function and overall reduced quality of life. While external compression of the rotator cuff tendons is thought to contribute to the progression and pathogenesis of rotator cuff damage, the mechanism by which this occurs and the role of aging in this process is unknown. The overall objective of the studies proposed is to determine the baseline ability of mature and aged tendons to respond to compressive loading and to understand the consequences of an increased compressive loading environment on tendon function. The project outlined in the proposal combines work of fundamental basic research importance with work directed toward the future diagnosis and therapeutic treatment of early stage tendon degeneration. Overall, the project is designed to effectively train the applicant to develop the technical skills needed to establish a successful and independent research program in the future.

 描述(由申请人提供)：本提案的目的是为申请人提供矫形外科生物工程方面的示范研究培训。为实现这一目标，制定了一套由研究目标和大量培训活动组成的培训方案。退行性肩袖疾病影响超过50%的老年人口，导致严重的关节功能损害和整体生活质量下降。虽然肩袖肌腱的外压被认为是肩袖损伤的进展和发病机制，但其发生机制和衰老在这一过程中的作用尚不清楚。这些研究的总体目标是确定成熟和老化肌腱对压缩负荷反应的基线能力，并了解压缩负荷环境增加对肌腱功能的影响。提案中概述的项目将基础基础研究的重要性工作与针对早期肌腱变性的未来诊断和治疗工作结合在一起。总体而言，该项目旨在有效地培训申请者，以发展在未来建立一个成功和独立的研究计划所需的技术技能。