Cerebral Small Vessels in Motor and Cognitive Decline

运动和认知能力下降的大脑小血管

• 批准号: 9113334
• 负责人: FARZANEH A SOROND
• 金额: $ 29.21万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9113334
• 关键词: Blood Vessels; Boston; Brain; Brain imaging; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrum; Clinical; Clinical Trials; Clinical assessments; Cognition; Cognitive; Coupling; Data; Data Analyses; Dementia; Diffusion Magnetic Resonance Imaging; Disease Progression; Doppler Ultrasound; Elderly; Epidemiology; Future; Gait; Goals; Health; Homeostasis; Hyperemia; Impaired cognition; Impairment; Incidence; Individual; Knowledge; Lead; Lesion; Link; Measures; Memory; Microvascular Dysfunction; Monitor; Motor; Outcome; Pain; Participant; Population; Prevention; Process; Public Health; Research; Role; Speed; Spin Labels; Stroke; Testing; Therapeutic Intervention; Vascular Diseases; White Matter Hyperintensity; age related; aging population; base; cerebral microbleeds; cohort; design; disability; falls; follow-up; functional outcomes; gray matter; meter; motor impairment; population based; pre-clinical; preventive intervention; programs; white matter

DESCRIPTION (provided by applicant): Cognitive and motor impairments are the two most common causes of disability in older adults. These two problems can lead to disabling forms of dementia and falls. Age-related cognitive and mobility impairments are clearly multifactorial, but with the rampant incidence of vascular disease in an aging population we cannot underestimate the role of cerebrovascular disease in age-related mobility disability and cognitive decline. Increasing evidence from epidemiological and clinico- pathological studies has established a strong link between vascular disease, particularly cerebral small vessel disease and the age related clinical outcomes of cognitive and mobility impairment. However, our current research and knowledge is based on surrogate radiographic measures of small vessel disease which are mostly irreversible. The overall goal of this study is to identify vascular measures of cerebral small vessels which precede the onset of cognitive and motor decline and are predictive of clinical and radiographic outcomes in small vessel disease. Such measures would allow us to identify individuals in the pre-clinical state when our prevention and therapeutic interventions could have a higher impact. Moreover, these measures can also be used in future clinical trials to monitor disease progression and to evaluate new therapies.

描述（由申请人提供）：认知和运动障碍是老年人残疾的两个最常见原因。这两个问题会导致致残形式的痴呆和跌倒。与年龄相关的认知和行动障碍显然是多因素的，但随着老龄化人口中血管疾病的猖獗发病率，我们不能低估脑血管疾病在与年龄相关的行动障碍和认知能力下降中的作用。来自流行病学和临床病理学研究的越来越多的证据表明，血管疾病，特别是脑血管疾病与年龄相关的认知和行动障碍的临床结果之间存在密切联系。然而，我们目前的研究和知识是基于小血管疾病的替代放射测量，这些测量大多是不可逆转的。本研究的总体目标是确定在认知和运动能力下降之前大脑小血管的血管测量，并预测小血管疾病的临床和影像学结果。这些措施将使我们能够识别处于临床前状态的个体，此时我们的预防和治疗干预可能会产生更高的影响。此外，这些措施也可用于未来的临床试验，以监测疾病进展和评估新的治疗方法。