Cerebral Small Vessels in Motor and Cognitive Decline

运动和认知能力下降的大脑小血管

• 批准号: 9258511
• 负责人: FARZANEH A SOROND
• 金额: $ 44.7万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9258511
• 关键词: Appearance; Biological Markers; Blood Vessels; Boston; Brain; Brain Injuries; Brain imaging; Cerebral small vessel disease; Cerebrovascular Disorders; Cerebrum; Clinical; Clinical Trials; Clinical assessments; Cognition; Cognitive; Data; Data Analyses; Dementia; Development; Diagnostic radiologic examination; Disease Progression; Doppler Ultrasound; Elderly; Epidemiology; Future; Gait; Gait speed; Goals; Homeostasis; Impaired cognition; Impairment; Incidence; Individual; Knowledge; Lacunar Infarctions; Lead; Lesion; Link; Magnetic Resonance Imaging; Measures; Mediating; Microvascular Dysfunction; Monitor; Motor; Onset of illness; Outcome; Pain; Participant; Pathologic; Population; Population Study; Prevention; Preventive Intervention; Process; Public Health; Research; Role; Testing; Therapeutic Intervention; Vascular Diseases; White Matter Hyperintensity; age related; aging population; base; burden of illness; cerebral microbleeds; cerebrovascular; clinical development; clinical predictors; cohort; design; disability; falls; follow-up; functional outcomes; indexing; longitudinal analysis; meter; motor impairment; neurovascular coupling; novel therapeutics; population based; pre-clinical; predictive marker; programs; public health relevance

DESCRIPTION (provided by applicant): Cognitive and motor impairments are the two most common causes of disability in older adults. These two problems can lead to disabling forms of dementia and falls. Age-related cognitive and mobility impairments are clearly multifactorial, but with the rampant incidence of vascular disease in an aging population we cannot underestimate the role of cerebrovascular disease in age-related mobility disability and cognitive decline. Increasing evidence from epidemiological and clinico-pathological studies has established a strong link between vascular disease, particularly cerebral small vessel disease and the age- related clinical outcomes of cognitive and mobility impairment. However, our current research and knowledge is based on surrogate radiographic measure of small vessel disease which are mostly irreversible. The overall goal of this study is to identify vascular measures of cerebral small vessels which precede the onset of cognitive and motor decline and are predictive of clinical and radiographic outcomes in small vessel disease. Such measures would allow us to identify individuals in the pre-clinical state when our prevention and therapeutic interventions could have a higher impact. Moreover, these measures can also be used in future clinical trials to monitor disease progression and to evaluate new therapies.

描述（由申请人提供）：认知和运动障碍是老年人残疾的两个最常见原因。这两个问题会导致失能性痴呆和福尔斯。脑血管疾病相关的认知和活动障碍显然是多因素的，但随着老龄化人口中血管疾病的发病率越来越高，我们不能低估脑血管疾病在与年龄相关的活动障碍和认知能力下降中的作用。越来越多的流行病学和临床病理学研究证据表明，血管疾病（尤其是脑小血管疾病）与年龄相关的认知和运动障碍临床结局之间存在密切联系。然而，我们目前的研究和知识是基于小血管疾病的替代放射学测量，这些疾病大多是不可逆的。本研究的总体目标是确定脑小血管的血管测量值，这些测量值在认知和运动功能下降发生之前，可预测小血管疾病的临床和影像学结局。这些措施将使我们能够在我们的预防和治疗干预措施可能产生更大影响的情况下确定处于临床前状态的个人。此外，这些措施也可以用于未来的临床试验，以监测疾病进展和评估新的治疗方法。