Request for High-Resolution Peripheral Quantitative Computed Tomography

要求高分辨率外围定量计算机断层扫描

• 批准号: 8947459
• 负责人: DENNIS T. VILLAREAL
• 金额: --
• 依托单位: MICHAEL E DEBAKEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8947459
• 关键词: 3-Dimensional; Acceleration; Address; Affect; Back; Biological Markers; Bone Density; Bone Mineral Contents; CYP19A1 gene; Calibration; Caring; Center for Translational Science Activities; Charge; Clinical; Collaborations; Computer software; Computers; Core Facility; Coupled; Densitometry; Diabetes Mellitus; Disease; Distal; Doctor of Philosophy; Ensure; Equipment; Fatty acid glycerol esters; Fees; Finite Element Analysis; Fostering; Foundations; Funding; Generations; Goals; Health Priorities; Healthcare; Heart failure; Human; Hypogonadism; Image; Image Analysis; Inflammatory; Interdisciplinary Study; Intervention; Laboratories; Leadership; Life Style; Lifestyle Therapy; Maintenance; Malignant Neoplasms; Measures; Medical; Medical center; Metabolic; Metabolic Bone Diseases; Methods; Minor; Modeling; Monitor; Muscle; Obesity; Osteoporosis; Outcome; Parkinson Disease; Patients; Peripheral; Pharmacogenetics; Physicians; Porosity; Preventive; Property; Radial; Radiation; Recruitment Activity; Request for Applications; Research; Research Personnel; Research Project Grants; Resolution; Role; Scanning; Scientist; Software Tools; Speed; Staging; Structure; Syndrome; System; Testosterone; Thick; Time; Traumatic Brain Injury; Tube; Veterans; Walking; Weight; X-Ray Computed Tomography; base; benefit sharing; bone; bone metabolism; bone quality; bone strength; calcification; cancer cachexia; career development; density; design; detector; evidence base; experience; follow-up; ghrelin; in vivo; innovation; interest; investigator training; morphometry; novel; novel strategies; operation; programs; public health relevance; reconstruction; research and development; response; tibia

 DESCRIPTION (provided by applicant): The present application is in response to Request for Application Number: BX-14-015 (ORD Shared Equipment Program [ISI]). The purpose is to make available to the Michael E DeBakey VA Medical Center (MEDVAMC) a high resolution peripheral quantitative computed tomography (HR-pQCT), as shared equipment and expand multiple VA funded veteran-centric research projects. The HR-pQCT is a non-invasive, low-radiation method that provides an unprecedented ability to measure three-dimensional (3-D) human bone microarchitecture and volumetric bone mineral density (vBMD) in vivo. Coupled with computer-based finite element analyses (FEA) modeling, the HR-pQCT also provides a novel approach to noninvasively assess bone strength. The HR-pQCT will be the Xtreme CTII (Scanco USA, Inc, Southeastern, PA), the new generation HR-pQCT, designed to quantify the 3-D microarchitecture of bone and vBMD at even higher precision and speed than its predecessor, the Xtreme CT. The system is particularly suited to assess and monitor treatment (e.g. response to lifestyle and pharmacologic interventions) of metabolic bone diseases and other inflammatory conditions such as diabetes, obesity, and cancer. The research projects to be significantly benefited by the shared HR-pQCT equipment will include 4 Merit Review (101 CX000906: "Testosterone Replacement to Augment Lifestyle Therapy in Obese Older Veterans; 101 CX000424: "CYP19A1 Gene and Pharmacogenetics of Response to Testosterone Therapy"; 101 CX000174: "The Role of Ghrelin in Cancer Cachexia"; 101CXS001112: "Biomarker Guided Therapies in Stage A/B Heart Failure") and 1 Career Development (IK2 TX000734: "Multidirectional Treadmill Walking in Parkinson Disease") VA-supported projects from 5 "major" 8/8th VA salaried users (Dennis T. Villareal, MD, Reina C. Villareal, MD, Jose Garcia, MD, PhD, Vijay Nambi, MD, Monthaporn Bryant PT, PhD) and 4 research projects from several "minor" users (e.g. DOD, foundation-supported projects). Thus, the spectrum of priority-health problems addressed by these VA-centric research projects are varied (obesity, metabolic bone disorders, hypogonadism, heart failure, cancer, traumatic brain injury, etc.), ensuring maximum and efficient utilization of shared equipment for the acceleration of research progress and improvement of veteran care. Multiple MEDVAMC investigators can immediately add novel outcomes such as bone microarchitecture and vBMD to ongoing VA funded research, which will significantly impact the advancement of health care of veterans. The HR-pQCT Core Facility will be directed by Dr. Dennis T. Villareal, a VA Physician-Scientist with leadership experience and research expertise that includes Bone metabolism and Clinical Densitometry. The HR-pQCT Core Facility will be integrated within the Imaging Core Facility of our internally-funded Center for Translational Research on Inflammatory Disease (CTRID) at MEDVAMC. The CTRID has recently recruited a full time laboratory manager who will have primary responsibility for assisting with the operation of the equipment, training of investigators on equipment use, managing of equipment access, and coordinating of collaborative research. A modest charge back fee for funded investigators will supplement the financial plan for long-term operation and management of the equipment. The CTRID will continue to host weekly research seminars to discuss research progress and plan research grant applications that capitalize on the novel applications of the HR-pQCT. The facility director and R&D committee fully endorse this application, including support for long-term preventive maintenance of the equipment. The broad, long-term objectives of the HR-pQCT shared equipment are to build the research capabilities of MEDVAMC, foster collaborative interdisciplinary research among MEDVAMC investigators, recruit new VA researchers to MEDVAMC, and create innovations that advance the health care for our veterans and the nation, consistent with VAMC's long term research goals.

 本申请是对申请号BX-14-015（ORD共享设备计划[ISI]）的请求的响应。目的是为Michael E DeBakey VA医疗中心（MEDVAMC）提供高分辨率外周定量计算机断层扫描（HR-pQCT），作为共享设备，并扩大多个VA资助 以退伍军人为中心的研究项目HR-pQCT是一种无创、低辐射的方法，可提供前所未有的能力来测量三维（3-D）人体骨微结构和体积骨矿物质密度（vBMD）。结合基于计算机的有限元分析（FEA）建模，HR-pQCT还提供了一种无创评估骨强度的新方法。HR-pQCT将是Xtreme CTII（美国宾夕法尼亚州东南部的Scorio公司），新一代HR-pQCT，旨在以比其前身Xtreme CT更高的精度和速度量化骨和vBMD的三维微结构。该系统特别适合于评估和监测代谢性骨疾病和其他炎性病症（如糖尿病、肥胖症和癌症）的治疗（例如，对生活方式和药物干预的反应）。共享HR-pQCT设备显著受益的研究项目将包括4项Merit评审（101 CX 000906：“肥胖老年退伍军人中的Tehran替代以增强生活方式治疗; 101 CX 000424： “CYP 19 A1基因和对替吉奥治疗反应的药物遗传学”; 101 CX 000174：“Ghrelin在癌症恶病质中的作用”; 101 CXS 001112：“A/B期心力衰竭的生物标志物指导治疗”）和1职业发展（IK 2 TX 000734：“帕金森病患者的多向跑步机行走”）VA支持的来自5个“主要”8/8 VA受薪用户的项目（Dennis T. David，MD. Villareal，MD，Jose Garcia，MD，PhD，Vijay Nambi，MD，Monthaporn Bryant PT，PhD）和来自几个“次要”用户的4个研究项目（例如，国防部，基金会支持的项目）。因此，在本发明中， 这些以VA为中心的研究项目所解决的优先健康问题的范围是多种多样的（肥胖、代谢性骨紊乱、性腺功能减退、心力衰竭、癌症、创伤性脑损伤等），确保最大限度和有效地利用共享设备，以加快研究进展和改善退伍军人护理。多个MEDVAMC研究人员可以立即将骨微结构和vBMD等新结果添加到正在进行的VA资助的研究中，这将显著影响退伍军人医疗保健的进步。HR-pQCT核心机构将由Dennis T. Villareal是一名VA医生-科学家，具有领导经验和研究专业知识，包括骨代谢和临床密度测定。HR-pQCT核心设施 将被整合到MEDVAMC内部资助的炎症性疾病转化研究中心（CTRID）的成像核心设施中。CTRID最近招聘了一名全职实验室经理，主要负责协助设备操作、培训研究人员使用设备、管理设备访问以及协调合作研究。对有经费的调查员收取的少量费用将补充设备长期运作和管理的财务计划。关于CTRID 将继续举办每周一次的研究研讨会，讨论研究进展，并计划利用HR-pQCT的新应用申请研究资助。设施主任和研发委员会完全赞同这一申请，包括支持设备的长期预防性维护。HR-pQCT共享设备的广泛，长期目标是建立MEDVAMC的研究能力，促进MEDVAMC研究人员之间的跨学科合作研究，招募新的VA研究人员到MEDVAMC，并创造创新，促进我们的退伍军人和国家的医疗保健，与VAMC的长期研究目标一致。