Request for High-Resolution Peripheral Quantitative Computed Tomography

要求高分辨率外围定量计算机断层扫描

• 批准号: 8947459
• 负责人: DENNIS T. VILLAREAL
• 金额: --
• 依托单位: MICHAEL E DEBAKEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8947459
• 关键词: 3-Dimensional; Acceleration; Address; Affect; Back; Biological Markers; Bone Density; Bone Mineral Contents; CYP19A1 gene; Calibration; Caring; Center for Translational Science Activities; Charge; Clinical; Collaborations; Computer software; Computers; Core Facility; Coupled; Densitometry; Diabetes Mellitus; Disease; Distal; Doctor of Philosophy; Ensure; Equipment; Fatty acid glycerol esters; Fees; Finite Element Analysis; Fostering; Foundations; Funding; Generations; Goals; Health Priorities; Healthcare; Heart failure; Human; Hypogonadism; Image; Image Analysis; Inflammatory; Interdisciplinary Study; Intervention; Laboratories; Leadership; Life Style; Lifestyle Therapy; Maintenance; Malignant Neoplasms; Measures; Medical; Medical center; Metabolic; Metabolic Bone Diseases; Methods; Minor; Modeling; Monitor; Muscle; Obesity; Osteoporosis; Outcome; Parkinson Disease; Patients; Peripheral; Pharmacogenetics; Physicians; Porosity; Preventive; Property; Radial; Radiation; Recruitment Activity; Request for Applications; Research; Research Personnel; Research Project Grants; Resolution; Role; Scanning; Scientist; Software Tools; Speed; Staging; Structure; Syndrome; System; Testosterone; Thick; Time; Traumatic Brain Injury; Tube; Veterans; Walking; Weight; X-Ray Computed Tomography; base; benefit sharing; bone; bone metabolism; bone quality; bone strength; calcification; cancer cachexia; career development; density; design; detector; evidence base; experience; follow-up; ghrelin; in vivo; innovation; interest; investigator training; morphometry; novel; novel strategies; operation; programs; public health relevance; reconstruction; research and development; response; tibia

 DESCRIPTION (provided by applicant): The present application is in response to Request for Application Number: BX-14-015 (ORD Shared Equipment Program [ISI]). The purpose is to make available to the Michael E DeBakey VA Medical Center (MEDVAMC) a high resolution peripheral quantitative computed tomography (HR-pQCT), as shared equipment and expand multiple VA funded veteran-centric research projects. The HR-pQCT is a non-invasive, low-radiation method that provides an unprecedented ability to measure three-dimensional (3-D) human bone microarchitecture and volumetric bone mineral density (vBMD) in vivo. Coupled with computer-based finite element analyses (FEA) modeling, the HR-pQCT also provides a novel approach to noninvasively assess bone strength. The HR-pQCT will be the Xtreme CTII (Scanco USA, Inc, Southeastern, PA), the new generation HR-pQCT, designed to quantify the 3-D microarchitecture of bone and vBMD at even higher precision and speed than its predecessor, the Xtreme CT. The system is particularly suited to assess and monitor treatment (e.g. response to lifestyle and pharmacologic interventions) of metabolic bone diseases and other inflammatory conditions such as diabetes, obesity, and cancer. The research projects to be significantly benefited by the shared HR-pQCT equipment will include 4 Merit Review (101 CX000906: "Testosterone Replacement to Augment Lifestyle Therapy in Obese Older Veterans; 101 CX000424: "CYP19A1 Gene and Pharmacogenetics of Response to Testosterone Therapy"; 101 CX000174: "The Role of Ghrelin in Cancer Cachexia"; 101CXS001112: "Biomarker Guided Therapies in Stage A/B Heart Failure") and 1 Career Development (IK2 TX000734: "Multidirectional Treadmill Walking in Parkinson Disease") VA-supported projects from 5 "major" 8/8th VA salaried users (Dennis T. Villareal, MD, Reina C. Villareal, MD, Jose Garcia, MD, PhD, Vijay Nambi, MD, Monthaporn Bryant PT, PhD) and 4 research projects from several "minor" users (e.g. DOD, foundation-supported projects). Thus, the spectrum of priority-health problems addressed by these VA-centric research projects are varied (obesity, metabolic bone disorders, hypogonadism, heart failure, cancer, traumatic brain injury, etc.), ensuring maximum and efficient utilization of shared equipment for the acceleration of research progress and improvement of veteran care. Multiple MEDVAMC investigators can immediately add novel outcomes such as bone microarchitecture and vBMD to ongoing VA funded research, which will significantly impact the advancement of health care of veterans. The HR-pQCT Core Facility will be directed by Dr. Dennis T. Villareal, a VA Physician-Scientist with leadership experience and research expertise that includes Bone metabolism and Clinical Densitometry. The HR-pQCT Core Facility will be integrated within the Imaging Core Facility of our internally-funded Center for Translational Research on Inflammatory Disease (CTRID) at MEDVAMC. The CTRID has recently recruited a full time laboratory manager who will have primary responsibility for assisting with the operation of the equipment, training of investigators on equipment use, managing of equipment access, and coordinating of collaborative research. A modest charge back fee for funded investigators will supplement the financial plan for long-term operation and management of the equipment. The CTRID will continue to host weekly research seminars to discuss research progress and plan research grant applications that capitalize on the novel applications of the HR-pQCT. The facility director and R&D committee fully endorse this application, including support for long-term preventive maintenance of the equipment. The broad, long-term objectives of the HR-pQCT shared equipment are to build the research capabilities of MEDVAMC, foster collaborative interdisciplinary research among MEDVAMC investigators, recruit new VA researchers to MEDVAMC, and create innovations that advance the health care for our veterans and the nation, consistent with VAMC's long term research goals.

 描述（由申请人提供）：本申请是对申请号请求的响应：BX-14-015（ORD共享设备计划[ISI]）。目的是为 Michael E DeBakey VA 医疗中心 (MEDVAMC) 提供高分辨率外围定量计算机断层扫描 (HR-pQCT)，作为共享设备并扩大多个 VA 资助 以退伍军人为中心的研究项目。 HR-pQCT 是一种非侵入性、低辐射方法，提供前所未有的体内测量三维 (3-D) 人体骨骼微结构和体积骨矿物质密度 (vBMD) 的能力。与基于计算机的有限元分析 (FEA) 建模相结合，HR-pQCT 还提供了一种无创评估骨强度的新方法。 HR-pQCT 是 Xtreme CTII（Scanco USA, Inc，宾夕法尼亚州东南部），是新一代 HR-pQCT，旨在以比其前身 Xtreme CT 更高的精度和速度量化骨骼和 vBMD 的 3D 微结构。该系统特别适合评估和监测代谢性骨疾病和其他炎症性疾病（例如糖尿病、肥胖症和癌症）的治疗（例如对生活方式和药物干预的反应）。受益于共享 HR-pQCT 设备的研究项目将包括 4 项优异评审（101 CX000906：“睾酮替代以增强肥胖老年退伍军人的生活方式治疗；101 CX000424： “CYP19A1基因和睾酮治疗反应的药物遗传学”； 101 CX000174：“生长素释放肽在癌症恶病质中的作用”； 101CXS001112：“A/B 期心力衰竭的生物标志物引导治疗”）和 1 个职业发展（IK2 TX000734：“帕金森病中的多向跑步机行走”）VA 支持的项目，来自 5 个“主要”8/8 VA 受薪用户（医学博士 Dennis T. Villareal、医学博士 Reina C. Villareal、医学博士、Jose Garcia、 博士、Vijay Nambi 医学博士、Monthaporn Bryant PT 博士）以及来自几个“次要”用户的 4 个研究项目（例如 DOD、基金会支持的项目）。因此， 这些以退伍军人事务部为中心的研究项目解决的重点健康问题多种多样（肥胖、代谢性骨疾病、性腺功能减退、心力衰竭、癌症、创伤性脑损伤等），确保最大限度和有效地利用共享设备，以加速研究进展和改善退伍军人护理。多个 MEDVAMC 研究人员可以立即将骨微结构和 vBMD 等新成果添加到 VA 资助的正在进行的研究中，这将显着影响退伍军人医疗保健的进步。 HR-pQCT 核心设施将由退伍军人管理局医师科学家 Dennis T. Villareal 博士领导，他拥有领导经验和研究专业知识，包括骨代谢和临床密度测定。 HR-pQCT 核心设施 将整合到 MEDVAMC 内部资助的炎症性疾病转化研究中心 (CTRID) 的成像核心设施内。 CTRID 最近招聘了一名全职实验室经理，他将主要负责协助设备操作、培训研究人员设备使用、管理设备访问以及协调合作研究。为受资助的研究人员提供适度的退款费用将补充设备长期运营和管理的财务计划。 CTRID 将继续每周举办研究研讨会，讨论研究进展并规划利用 HR-pQCT 新颖应用的研究资助申请。设施总监和研发委员会完全认可该申请，包括对设备长期预防性维护的支持。 HR-pQCT 共享设备的广泛、长期目标是建立 MEDVAMC 的研究能力，促进 MEDVAMC 研究人员之间的跨学科合作研究，招募新的 VA 研究人员到 MEDVAMC，并创造创新，促进我们退伍军人和国家的医疗保健，这与 VAMC 的长期研究目标一致。