SWAN Repository III

此竞争性续期申请旨在为持续维护和相关活动提供资金 与10年产生的血清、血浆、尿液、DNA和转化细胞的SWAN储存库一起使用 对来自5个民族的3302名妇女进行了研究， 在绝经过渡期和之后。这些知识库是妇女健康研究的一个分支， 全国范围内（天鹅），是为了支持，促进和扩大核心天鹅;此外， 知识库提供了一种机制，向更大的科学界开放SWAN的资源。 实施与这一竞争性更新的三个拟议具体目标相关的活动将：1） 为继续管理现有的170万个储存库标本和额外的 2009年至2014年部署天鹅四号后将积累的标本; 2）扩大DNA储存库， 由于我们对细胞的投资，最常见的可再生标本类型 3）促进有关SWAN研究及其数据和 通过开发一个两级网络“数据仓库”， 继续管理标本利用和行政管理的申请审查程序 管理样本分配，包括材料转让协议; 5）参与战略， 促进标本的利用; 6）扩大与遗传学相关的研究范围。 SWAN研究及其储存库。

This competing renewal application is to provide for the continued maintenance of and activities associated with the SWAN Repositories of serum, plasma, urine, DNA and transformed cells generated from a 10-year study of a population of 3302 women from 5 ethnic groups who have been evaluated annually prior to, during and following the menopausal transition. These Repositories, an arm of the Study of Women's Health Across the Nation (SWAN), is meant to support, facilitate and extend the Core SWAN; additionally, the Repositories provide a mechanism for opening the resources of SWAN to the greater scientific community. Implementing activities associated with three proposed specific aims of this competing renewal will 1) provide for the continued management of the current 1.7 million Repository specimens and the additional specimens that will accrue as a result of fielding SWAN IV in 2009 to 2014; 2) expand the DNA Repository, the most frequently requested specimen type that is uniquely renewable because of our investment in cell immortalization; 3) promote effective information interchange about the SWAN Study, its data and the Repository resources through development of a 2-level web-based "data warehouse"; 4) provide for continued administration of the application review process for specimen utilization and administrative management of specimen distribution including Material Transfer Agreements; 5) engage in strategies to promote utilization of specimens; and, 6) expand the scope of the genetics studies associated with the SWAN study and its Repository.