STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM

STRAW 10：解决生殖衰老阶段未完成的议程 - RESUBM

• 批准号: 8202368
• 负责人: Sioban D Harlow
• 金额: $ 5.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8202368
• 关键词: AIDS/HIV problem; Address; Adopted; Aging; Algorithms; American; Antral; Biological Markers; Body mass index; Bone Resorption; Categories; Child; Child health care; Chronic Disease; Classification; Climacteric; Clinical; Clinical Trials; Consensus; Contraceptive Agents; Data; Decision Making; District of Columbia; Educational workshop; Endocrine; Endocrine System Diseases; Ensure; Fertility; Follicle Stimulating Hormone; Funding; Gender; Gold; Gynecologic Surgical Procedures; Health; Healthcare; Hormones; Human Development; Hypothalamic structure; Institutes; International; Journals; Knowledge; Life; Lipids; Medicine; Menopausal Status; Menopause; Menstruation; Mental Depression; Modeling; Modification; National Institute on Aging; Nomenclature; Outcome; Ovarian; Peer Review; Physiological; Postmenopause; PubMed; Puberty; Publishing; Quality of life; Recommendation; Recording of previous events; Reproductive Medicine; Research; Research Personnel; Research Priority; Risk; Sleep disturbances; Smoke; Societies; Specific qualifier value; Staging; Staging System; Sterility; Symptoms; Syndrome; Time; Translating; United States; Update; Uterine hemorrhage; Woman; Women' s Group; Women' s Health; base; bone; chemotherapy; critical period; experience; healthy aging; hormone therapy; indexing; inhibin B; meetings; middle age; mullerian-inhibiting hormone; multidisciplinary; population based; reproductive; research study; senescence; success; symposium; tool; web site; working group

DESCRIPTION (provided by applicant): We propose a multi-disciplinary symposium "STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging" to update the 2001 Stages of Reproductive Aging Workshop (STRAW) recommendations. The menopausal transition is a period of critical change, including loss of fertility, increased bone resorption, change in lipid profiles and temporal increases in symptoms, sleep disturbances and depression. STRAW proposed nomenclature, a staging system, and menstrual and endocrine criteria to define stages of ovarian aging. It has become the gold standard for characterizing reproductive aging, as the Tanner Stages characterize puberty. In the past decade, understanding of the critical junctures in hypothalamic and ovarian function before and after the final menstrual period and their implications for women's health has advanced considerably. We will convene 30 investigators from key research groups in the United States and worldwide. The specific aims are to refine criteria for the early menopausal transition given new population-based data relating to follicle-stimulating hormone, antral follicle count, anti-mullerian hormone and inhibin-B; to assess how to include women with higher body-mass-index and who smoke in staging algorithms; to provide recommendations regarding staging of women following gynecological surgery, chemotherapy, and hormone therapy and in women with polycystic ovarian syndrome and chronic diseases such as HIV/AIDS; and to assess potential criteria for staging the post-menopause. The Day 1 public scientific sessions will present recent advances and discuss implications of new data for staging. On Day 2, small working groups will propose modifications to the STRAW criteria. Following discussion, final recommendations will be adopted and research priorities defined. The expected outcome will be a set of recommendations for modifying the STRAW criteria that characterize the end stages of reproductive life including their extension to be more broadly applicable to the range of women's experience. Short- and long-term research priorities will be specified including studies needed to replicate and validate proposed criteria as well as to address gaps in knowledge. The meeting, co-sponsored by The North American Menopause Society (NAMS), The American Society for Reproductive Medicine, The International Menopause Society and The Endocrine Society, will be held September 20-21, 2011 prior to the NAMS Annual Meeting in Washington D.C. STRAW+10 recommendations will be presented at the NAMS meeting. A peer-reviewed executive summary will be published simultaneously in the co-sponsors' journals, Climacteric, Menopause, Fertility and Sterility; with a non-technical version published on their websites. The STRAW+10 staging system will facilitate consistent classification of menopausal status, ensuring comparability of research studies and clinical trials. Once specified, a staging system can be developed into a clinical tool to guide assessment of fertility and contraceptive choices, and healthcare decision-making. Funds will be allocated to support participation of 4 trainees/new investigators. PUBLIC HEALTH RELEVANCE: The purpose of this multi-disciplinary 2-day symposium is to organize and synthesize knowledge accumulated during the past decade in order to update the 2001 Stages of Reproductive Aging Workshop (STRAW) model for staging the end of reproductive life in women. We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging.

描述（由申请人提供）：我们建议举办一个多学科的研讨会“2000年+10：解决未完成的议程分期生殖老化”，以更新2001年生殖老化阶段工作坊（STATES）的建议。 绝经过渡期是一个关键的变化时期，包括生育能力丧失、骨吸收增加、血脂谱变化和症状、睡眠障碍和抑郁症的暂时增加。他提出了一个命名法、一个分期系统、月经和内分泌标准来定义卵巢老化的阶段。它已经成为表征生殖老化的黄金标准，因为坦纳阶段表征青春期。在过去的十年中，下丘脑和卵巢功能的关键节点之前和之后的最后一次月经期及其对妇女健康的影响的理解有了很大的进步。我们将召集来自美国和世界各地主要研究小组的30名研究人员。 具体目标是：根据有关卵泡刺激素、窦卵泡计数、抗苗勒管激素和β-雌二醇的新的基于人口的数据，完善绝经早期过渡的标准;评估如何将体重指数较高和吸烟的妇女纳入分期算法;提供关于妇科手术，化疗，和激素治疗以及患有多囊卵巢综合征和慢性疾病如艾滋病毒/艾滋病的妇女;并评估绝经后分期的潜在标准。第一天的公共科学会议将介绍最新进展，并讨论新数据对分期的影响。在第二天，小型工作组将提出对可持续发展标准的修改。经过讨论，将通过最后建议，并确定研究优先事项。预期的成果将是提出一套建议，修改界定生殖生命末期的生殖健康标准，包括将其扩大，以便更广泛地适用于妇女的各种经历。短期和长期研究优先事项将得到具体说明，包括为复制和验证拟议标准以及填补知识空白所需的研究。 该会议由北美更年期协会（NAMS）、美国生殖医学协会、国际更年期协会和内分泌协会共同主办，将于2011年9月20日至21日在华盛顿举行的NAMS年会之前举行。NAMS会议将提出10项建议。同行评审的执行摘要将同时在共同赞助者的期刊《更年期》、《更年期》、《生育力》和《不育》上发表;非技术版本将在其网站上发表。10 +10分期系统将促进绝经状态的一致分类，确保研究和临床试验的可比性。一旦指定，分期系统可以发展成为一种临床工具，以指导评估生育和避孕选择，以及医疗决策。资金将用于支持4名受训人员/新调查员的参与。 公共卫生相关性：这个为期两天的多学科研讨会的目的是组织和综合过去十年积累的知识，以更新2001年生殖衰老阶段研讨会（STAGES）的妇女生殖生命结束阶段模型。我们还提议扩大妇女地位委员会的建议，使其更广泛地适用于妇女在生殖老龄化方面的各种经历。