Miroscopy

显微镜检查

• 批准号: 9149810
• 负责人: FRANK B GERTLER
• 金额: $ 19.34万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-09 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149810
• 关键词: Animals; Budgets; Cancer Center; Cancer Center Support Grant; Cells; Confocal Microscopy; Core Grant; Custom; Development; Diagnostic; Electron Microscopy; Equipment; Image; Imaging technology; Institutes; Life; Light; Malignant Neoplasms; Microfluidic Microchips; Microscopic; Microscopy; Mission; Molecular; Nanostructures; Research Institute; Research Personnel; Research Support; Resolution; Resource Sharing; Scanning; Spectral Karyotyping; Tissues; Total Internal Reflection Fluorescent; Training; base; bioluminescence imaging; cellular imaging; design; image processing; in vivo; instrumentation; intravital imaging; laser capture microdissection; member; nanomaterials; programs; success; tool

A primary focus of the Koch Institute’s research program is to understand the molecular and cellular changes associated with cancer development and progression and develop new treatments and diagnostic approaches. The Microscopy Core provides state-of-the-art imaging in both cells and in the in vivo setting, which are essential tools for these studies. In the current period, the capabilities of this Core have been expanded and enhanced. This includes: moving into a larger, custom-designed space in the new Koch Institute building; the acquisition of new instrumentation; and the recruitment of a world-renowned expert in intravital imaging, Jeffrey Wyckoff, to the Core’s staff. Notably, in the same period, 78% of Center Members used the Microscopy Core, including investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, this Core will continue to offer a wide range of state-of-the-art imaging technologies to support the research programs of Center Members. To support its expanded staff, the requested budget for Year 44 is increased 45%, compared to the requested and recommended budget in Year 39. The CCSG budgets of other Koch Institute Cores have been reduced or eliminated to more than offset the proposed increase in this, and other, Cores.

科赫研究所研究计划的主要重点是了解分子和细胞的变化 与癌症的发生和进展相关，并开发新的治疗和诊断方法。 显微镜核心可在细胞和体内环境中提供最先进的成像， 这些研究的重要工具。当前，该核心的功能已得到扩展， 增强。这包括：搬进科赫研究所新大楼内更大的定制设计空间；这 购置新仪器；并聘请了世界著名的活体成像专家 Jeffrey 威科夫（Wyckoff），致 Core 的员工。值得注意的是，在同一时期，78% 的中心成员使用了显微镜核心， 包括来自所有四个计划的研究人员。因此，这种共享资源对于项目的成功至关重要 科赫研究所的使命。在接下来的一段时间内，该核心将继续提供各种最先进的功能 成像技术支持中心成员的研究计划。为了支持其扩大的员工队伍， 与 2014 年请求和建议的预算相比，44 年请求的预算增加了 45% 39. 其他科赫研究所核心的 CCSG 预算已减少或取消，足以抵消 建议增加该核心和其他核心。