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Southern California Research Center for ALPD and Cirrhosis

南加州 ALPD 和肝硬化研究中心

基本信息

批准号：
9112542
负责人：
HIDEKAZU TSUKAMOTO
金额：
$ 1.5万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9112542
关键词：
Alcohol abuse Alcoholic Liver Diseases Alcohols Animal Model Animals California Cell Separation Cells Cholecystokinin Cirrhosis Collaborations Communities Development Disease Disease model Education Education and Outreach Educational process of instructing Environment Ethanol Exhibits Faculty Fostering Functional disorder Funding Future Generations Generations Goals Grant Health Personnel Hepatic Stellate Cell Hepatitis C virus Hepatocyte Home environment Hybrids Infusion procedures Institution International Life Style Liver Liver Fibrosis Mediating Medical Mission Modeling Molecular Monoclonal Antibody R24 Morbidity - disease rate National Institute on Alcohol Abuse and Alcoholism Nuclear Pore Complex Oncogenic Outcome Pancreas Pancreatic Diseases Pathologic Pathology Patients Positioning Attribute Postdoctoral Fellow Predisposition Preparation Preventive Principal Investigator Program Research Project Grants Public Health Publications Research Research Infrastructure Research Personnel Research Training Resolution Resources Rodent Rodent Model Role Sampling Science Scientist Seminal Staging TLR4 gene Technology Therapeutic Time Tissues Training Training and Education Transgenic Mice Trypsinogen United States National Institutes of Health acute pancreatitis alcohol research base career development cell type clinically relevant collaborative environment feeding genetic approach graduate student in vivo innovation insight member mortality mouse model novel outreach problem drinker programs public health relevance symposium tumor tumorigenesis undergraduate student western diet

项目摘要

DESCRIPTION (provided by applicant): Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 57 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated to recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit. The center's interactive environment and infrastructure have facilitated in the past 5 years, a 152% increase in research base to $8.5M/year; 4 new UOl/POI programs; 198 publications; generation of 14 NIH-funded early-stage investigators; transition of 8 postdocs to faculty positions; training 166 graduate and 20 undergraduate students; and organizing 3 community seminars and 4 international symposia. As a unique national resource, the center has provided to scientific communities across the nation: 229 rodents as ALPD models and 241 model samples for 17 outside investigators; 329 liver cell isolation preparations for 14 investigators; and support for grant acquisition and application by 12 outside investigators since the last renewal. The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by promoting: 1) environment conducive for leading-edge research on the center's theme: elucidation of the priming and sensitizing mechanisms for ALPD; 2) provision of unique models, innovative genetic approaches and expertise to outside investigators including those at other NIAAA Alcohol Research Centers; 3) comprehensive education and training to foster future generations of scientists in ALPD and cirrhosis; and 4) outreach efforts to disseminate the center's new findings to lay public, health care workers and scientists in our home and global communities.

描述（由申请人提供）：酒精性肝脏和胰腺疾病（ALPD）和肝硬化构成了地球仪的主要生活方式疾病。南加州ALPD和肝硬化研究中心联合了来自南加州主要学术机构的57名研究人员，以追求共同的使命，即成为研究，培训和推广疾病的领导者。该中心自1999年成立以来，一直致力于开发和使用临床相关的动物模型，以获得对晚期ALPD易感性的分子机制的新见解。这些努力最终导致了最近的突破性发现，这些发现大大推进了我们对酒精和第二次打击引起的协同ALPD的理解。该中心的互动环境和基础设施在过去5年中促进了研究基础的152%增长，达到850万美元/年; 4个新的UOI/POI项目; 198篇出版物; 14名NIH资助的早期研究人员; 8名博士后向教师职位过渡;培训166名研究生和 20名本科生;组织3次社区研讨会和4次国际研讨会。作为一个独特的国家资源，该中心已提供给全国各地的科学界：229啮齿动物作为ALPD模型和241模型样本为17个外部调查员; 329肝细胞分离制备14个调查员;和支持赠款收购和申请12个外部调查员自上次更新。该中心将继续努力成为ALPD和肝硬化的独特卓越科学中心，促进：1）有利于中心主题前沿研究的环境：阐明ALPD的启动和致敏机制; 2）为外部研究人员提供独特的模型，创新的遗传方法和专业知识，包括其他NIAAA酒精研究中心的研究人员; 3）全面的教育和培训，以培养未来几代ALPD和肝硬化科学家;和4）外展工作，以传播该中心的新发现，以奠定公众，卫生保健工作者和科学家在我们的家庭和全球社区。