International Symposium on ALPD and Cirrhosis

描述（由申请人提供）：本R13申请寻求对将于2011-2015年举行的第6 ~ 10届酒精性肝脏和胰腺疾病（ALPD）与肝硬化国际研讨会的支持。该系列研讨会始于2006年，已成功地汇集了来自世界各地10~17个国家的120~200名研究人员，他们具有尖端和互补的专业知识，并产生了大量新的合作，导致该领域的重大进展。我们希望继续这一独特和协同作用的传统，以进一步促进ALPD和肝硬化的基础和转化研究，以及对这些影响全球数百万人的重要疾病的全球推广。研讨会的总体具体目标仍然是：（1）继续促进不同学科和国家之间的国际合作;（2）分享各国现有的互补资源和专业知识，从而增加协同作用和独特的想法;（3）鼓励年轻的研究人员在国际一级进行互动;（4）鼓励年轻的研究人员在国际一级进行交流。（四）向专业及非专业人士推广有助预防及治疗疾病的新科学及翻译资料。第6 ~ 8届研讨会将于2011年在日本福冈、2012年在中国北京、2013年在印度德里举行，主办单位已经选定。每一次科学会议都将有一个独特的总主题和分主题。第六届会议的初步方案已围绕“从干细胞到全球健康”的主题制定，经国际咨询委员会审查，并获得主办组织日本肝病学会和日本胃肠病学会的批准。专题会议包括：ALD中的干细胞，肝脏和胰腺癌; ASH和酒精性胰腺炎中的细胞死亡调节;对肝脏和胰腺纤维化的新见解; ALPD和肝硬化的新疗法;以及全球健康：酒精，吸烟和肥胖的影响。研讨会得到了NIAAA的R13机制的部分支持，以支付受邀美国演讲者的差旅费，并为年轻的研究人员提供旅行奖励。主办机构为会场和会议后勤提供了配套支持，还为来自非美国和主办国的受邀演讲者和年轻与会者提供了支持。今后的专题讨论会将遵循这一分担财务责任的机制，这将确保具有成本效益的会议管理，同时不损害科学和外联的协同成果。 公共卫生相关性：酒精性肝脏和胰腺疾病（ALPD）是世界上最常见的与酒精相关的生活方式疾病。为了在科学和推广层面解决这一全球性问题，自2006年以来，每年组织一次ALPD和肝硬化国际研讨会。这些会议促进了具有互补专业知识和资源的研究人员之间的积极国际合作，产生了有影响力的出版物，并导致ALPD和肝硬化领域的重大科学进步。在外联一级，主办组织已采取主动行动，成立了一个工作队或委员会，以提高对酒精相关疾病以及有助于预防和治疗这些疾病的相关基础科学和转化科学的认识。

DESCRIPTION (provided by applicant): This R13 application seeks support for the 6th~10th International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD) and Cirrhosis to be held in 2011-2015. This series of symposia began in 2006 and has been highly successful in bringing together 120~200 investigators from 10~17 nations around the world with cutting-edge and complementary expertise and generating a wealth of new collaborations that led to major advances in the field. We wish to continue this unique and synergizing tradition to further promote basic and translational research on ALPD and cirrhosis, as well as global outreach on these important diseases which affect millions of people world-wide. Overall specific aims of the symposia remain to be: 1) to continue to promote international collaboration among different disciplines and nations; 2) to share the complementary resources and expertise available in various countries, thus adding synergy and unique ideas together; 3) to encourage young investigators to interact at an international level; and 4) to promote dissemination to professional and lay communities of new scientific and translational information which can be helpful for prevention and treatment of the diseases. The 6th~8th symposia will be held in Fukuoka, Japan in 2011, in Beijing, China in 2012, and Deli, India in 2013, and their organizers have been selected. Each will have a unique general theme and subthemes for scientific sessions. A preliminary program for the 6th meeting has been created around the theme of "From Stem Cells to Global Health", reviewed by International Advisory Committee, and approved by Japanese Society of Hepatology and Japanese Society of Gastroenterology, the hosting organizations. Thematic sessions include: Stem Cells in ALD, Liver and Pancreatic Cancer; Cell Death Regulation in ASH and Alcoholic Pancreatitis; Novel Insights into Liver and Pancreatic Fibrogenesis; New Treatments of ALPD and Cirrhosis; and Global Health: Impacts of Alcohol, Smoking, and Obesity. The symposia have been supported in part by the NIAAA's R13 mechanism to defray travel costs of invited US speakers and to provide travel awards for young investigators. The hosting organization provided a matching support for the venue and meeting logistics, but also for invited speakers and young attendees from non-US and hosting nations. Future symposia will follow this mechanism of shared financial responsibility, which will assure cost-effective meeting management without compromising the synergistic outcome for science and outreach. PUBLIC HEALTH RELEVANCE: Alcoholic liver and pancreatic diseases (ALPD) represent the most common alcohol-associated life style diseases around the world. To address this global issue, both at the scientific and outreach levels, International Symposium on ALPD and Cirrhosis has been organized annually since 2006. These meetings have promoted active international collaborations among investigators with complementary expertise and resources, resulted in influential publications, and led to major advancements of science in the field of ALPD and cirrhosis. At the outreach level, the hosting organizations have taken the initiatives to create a task force or committee to promote the awareness of alcohol-associated diseases and related basic and translational science which can be helpful for prevention and treatment of the diseases.