Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration

评估单次/多发神经创伤对神经退行性变的影响

基本信息

  • 批准号:
    8869445
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-05-01 至 2019-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Increasing numbers of US Veterans are returning from military ventures suffering from blast exposure and traumatic brain injury (TBI). There is a critical need for a greater understanding of the long term and debilitating impairments in cognition, psychological health, and sensorimotor abilities. To further complicate the injury, combat personnel exposed to repeated concussions could find themselves with long-term sequelae. A significant number of these individuals are presenting with clinical symptoms of neurodegenerative diseases and cognitive decline. The number of these individuals is increasing with the current war and poses a major challenge for the Department of Veterans Affairs. Answers to fundamental neuroscience questions about the etiology of neurodegeneration in Veterans exposed to combat-related stress and TBI are lacking. Furthermore, it is not known how the acute injury progresses into a chronic pathology and symptomatology. With the large number of Veterans reported to have TBI, it is vital to study the long-term effects of TBI as it relates to the sequelae of neurological events following single or multiple exposures to trauma. One of the goals of this research is to establish a biological basis for identifying chronic TBI which could have a significant effect on diagnosis and differentiation from other neurological conditions. This ability could significantly benefit the patient diagnosis and differentiate it from other neurological conditions. The ultimate goal is to determine if various brain injury mechanisms advance the progression of memory loss and neurodegeneration. The research design involves experimental models of blast TBI. Using military-relevant neurotrauma rodent models, we expect to accomplish the following Specific Aims; (1) to establish the longitudinal effects of both single and multiple injuries in utilizing neurocognitive and behavioral assessments (2) to identify chronic biomarkers which correlate with neurodegeneration following single and repeated injuries and (3) to validate the progression of neurodegeneration using histological and molecular techniques. Understanding the long term consequences of neurotrauma and identifying the mechanisms underlying the transition from acute to chronic pathology will help to more effectively identify, treat and optimie rehabilitative strategies for our Veterans with TBI. Recent advances across our laboratories have demonstrated efficacy of rodents to model military-related TBI including multiple mild TBIs. However, data on long term outcomes are lacking and are required to most effectively provide rehabilitation strategies catering to the individual stage of injury and neurodegeneration progression. The ability to understand and measure injury progression makes this research highly relevant to the VA mission.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

PAMELA J. VANDEVORD其他文献

PAMELA J. VANDEVORD的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('PAMELA J. VANDEVORD', 18)}}的其他基金

Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    10904613
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    9888203
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    10454877
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    10265417
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Investigating Neurological Injury Patterns in the Minipig Following Impact
研究小型猪撞击后的神经损伤模式
  • 批准号:
    9512048
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration
评估单次/多发神经创伤对神经退行性变的影响
  • 批准号:
    9261399
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration
评估单次/多发神经创伤对神经退行性变的影响
  • 批准号:
    9901438
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Understanding the Injury Mechanism of Blast Neurotrauma
了解爆炸性神经外伤的损伤机制
  • 批准号:
    8979467
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Understanding the Injury Mechanism of Blast Neurotrauma
了解爆炸性神经外伤的损伤机制
  • 批准号:
    8395583
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了