Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration

评估单次/多发神经创伤对神经退行性变的影响

基本信息

  • 批准号:
    9901438
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-05-01 至 2019-09-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Increasing numbers of US Veterans are returning from military ventures suffering from blast exposure and traumatic brain injury (TBI). There is a critical need for a greater understanding of the long term and debilitating impairments in cognition, psychological health, and sensorimotor abilities. To further complicate the injury, combat personnel exposed to repeated concussions could find themselves with long-term sequelae. A significant number of these individuals are presenting with clinical symptoms of neurodegenerative diseases and cognitive decline. The number of these individuals is increasing with the current war and poses a major challenge for the Department of Veterans Affairs. Answers to fundamental neuroscience questions about the etiology of neurodegeneration in Veterans exposed to combat-related stress and TBI are lacking. Furthermore, it is not known how the acute injury progresses into a chronic pathology and symptomatology. With the large number of Veterans reported to have TBI, it is vital to study the long-term effects of TBI as it relates to the sequelae of neurological events following single or multiple exposures to trauma. One of the goals of this research is to establish a biological basis for identifying chronic TBI which could have a significant effect on diagnosis and differentiation from other neurological conditions. This ability could significantly benefit the patient diagnosis and differentiate it from other neurological conditions. The ultimate goal is to determine if various brain injury mechanisms advance the progression of memory loss and neurodegeneration. The research design involves experimental models of blast TBI. Using military-relevant neurotrauma rodent models, we expect to accomplish the following Specific Aims; (1) to establish the longitudinal effects of both single and multiple injuries in utilizing neurocognitive and behavioral assessments (2) to identify chronic biomarkers which correlate with neurodegeneration following single and repeated injuries and (3) to validate the progression of neurodegeneration using histological and molecular techniques. Understanding the long term consequences of neurotrauma and identifying the mechanisms underlying the transition from acute to chronic pathology will help to more effectively identify, treat and optimie rehabilitative strategies for our Veterans with TBI. Recent advances across our laboratories have demonstrated efficacy of rodents to model military-related TBI including multiple mild TBIs. However, data on long term outcomes are lacking and are required to most effectively provide rehabilitation strategies catering to the individual stage of injury and neurodegeneration progression. The ability to understand and measure injury progression makes this research highly relevant to the VA mission.
 描述(由申请人提供): 越来越多的美国退伍军人因遭受冲击波和创伤性脑损伤(TBI)而从军事冒险中归来。迫切需要更多地了解认知、心理健康和感觉运动能力方面的长期和衰弱的损害。让伤情进一步复杂化的是,反复遭受脑震荡的战斗人员可能会发现自己会有长期的后遗症。这些人中有相当多的人出现了神经退行性疾病和认知能力下降的临床症状。随着当前的战争,这些人的数量正在增加,这对退伍军人事务部构成了重大挑战。关于暴露在战斗相关压力和脑外伤中的退伍军人神经退行性变的病因,基本神经科学问题的答案是缺乏的。此外,目前尚不清楚急性损伤是如何发展为慢性病理和症状的。随着大量退伍军人被报道患有脑外伤,研究脑损伤的长期影响至关重要,因为它与单次或多次暴露于创伤后的神经事件的后遗症有关。这项研究的目标之一是建立一个生物学基础来识别慢性脑损伤,这可能对诊断和与其他神经系统疾病的鉴别具有重大影响。这种能力可以极大地帮助患者进行诊断,并将其与其他神经系统疾病区分开来。最终目标是确定不同的脑损伤机制是否会促进记忆丧失和神经退化的进展。研究设计包括冲击波TBI的实验模型。使用与军事相关的神经创伤啮齿动物模型,我们期望实现以下特定目标:(1)利用神经认知和行为评估建立单发和多发损伤的纵向效应;(2)识别与单发和重复损伤后神经退变相关的慢性生物标志物;(3)利用组织学和分子技术验证神经退变的进展。了解神经创伤的长期后果,并确定从急性到慢性病理转变的潜在机制,将有助于更有效地确定、治疗和优化退伍军人脑损伤的康复策略。我们实验室的最新进展证明了啮齿类动物在模拟军事相关脑损伤包括多个轻度脑损伤方面的有效性。然而,缺乏关于长期结果的数据,需要最有效地提供迎合损伤和神经退化进展的个体阶段的康复策略。了解和测量损伤进展的能力使这项研究与退伍军人管理局的任务高度相关。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Astrocyte Reactivity Following Blast Exposure Involves Aberrant Histone Acetylation.
  • DOI:
    10.3389/fnmol.2016.00064
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Bailey ZS;Grinter MB;VandeVord PJ
  • 通讯作者:
    VandeVord PJ
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PAMELA J. VANDEVORD其他文献

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{{ truncateString('PAMELA J. VANDEVORD', 18)}}的其他基金

Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    10904613
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    9888203
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    10454877
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Nanoparticles Mitigate Chronic Behavior and Neuropathology
纳米颗粒缓解慢性行为和神经病理学
  • 批准号:
    10265417
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Investigating Neurological Injury Patterns in the Minipig Following Impact
研究小型猪撞击后的神经损伤模式
  • 批准号:
    9512048
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration
评估单次/多发神经创伤对神经退行性变的影响
  • 批准号:
    9261399
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Evaluating Causative Effects of Single/Multiple Neurotrauma on Neurodegeneration
评估单次/多发神经创伤对神经退行性变的影响
  • 批准号:
    8869445
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Understanding the Injury Mechanism of Blast Neurotrauma
了解爆炸性神经外伤的损伤机制
  • 批准号:
    8979467
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Understanding the Injury Mechanism of Blast Neurotrauma
了解爆炸性神经外伤的损伤机制
  • 批准号:
    8395583
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
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