Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

从婴儿早期口腔微生物组了解儿童早期龋齿差异背后的生物因素

• 批准号: 10666930
• 负责人: STEVEN R. GILL
• 金额: $ 11.29万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10666930
• 关键词: Affect; Award; Behavior; Biological Factors; Birth; Child; Counseling; Data; Dental caries; Development; Dietary Iron; Dietetics; Eating Behavior; Exposure to; Foundations; Future; Health; Health Disparities Research; Household; Infant; Intake; Life; Low income; Mothers; Nutritionist; Oral; Oral candidiasis; Oral health; Parents; Perinatal; Pica Disease; Pregnancy; Pregnant Women; Prevention; Research; Research Personnel; Risk; Risk Factors; Solid; Underserved Population; Woman; Yeasts; career; cariogenic bacteria; cohort; dysbiosis; early childhood; early-life nutrition; ethnic minority; feeding; food insecurity; gut microbiome; in utero; infancy; microbial composition; microbiome research; minority communities; nutrition; oral microbial community; oral microbiome; oral supplementation; prenatal; racial and ethnic; racial disparity; skills; yeast infection

Project Summary Early childhood caries (ECC) disproportionately affects children from low-income households and ethnic minority communities. Dysbiosis of oral microbiota, including enrichment of cariogenic bacteria and yeast, increase the risk for ECC. Previous research indicated connections between in-utero and early-life nutrition intake and gut microbiome development. Yet, the impact of in-utero and early-life nutrition intake on maternal and children’s oral microbiome remains unclear. As an augmentation to the parent award R01DE031025 Oral Microbiome in Early Infancy (OMEI), we propose this supplement OMEI + Nutrition. The parent OMEI studies the early-life biological factors underlying ECC racial disparity via a valuable underserved birth cohort. In the OMEI+ Nutrition supplement, we expand the factors to include perinatal nutritive (such as dietary iron intake) and nonnutritive behavior (such as pica) to examine their potential relationships with oral microbiomes during pregnancy and early life. Our central hypothesis is that mothers with nonnutritive eating behavior are associated with a distinct oral microbial community, which influences oral microbiome development in early childhood. We propose the following aims in the OMEI + Nutrition study. Aim 1: Assess the effect of nutritive and nonnutritive eating behavior on the oral microbiome of pregnant women. Aim 2: Assess the impact of maternal nutritive and nonnutritive eating behavior on infants' early-life (birth to 6 months) oral Candida colonization and yeast infection. Aim 3 (Exploratory): assess microbial compositions of pica substances. The OMEI + Nutrition will be the first study that examines the relationship between nutritive (such as dietary iron intake) and nonnutritive (such as pica) factors on perinatal oral microbiome among underserved US pregnant women and their children. Data generated will strengthen the understanding of children’s oral microbiome development and their association to ECC. Additional risk factors revealed from this OMEI+ Nutrition would be used as targets for prenatal counselling, ECC early prediction and prevention, specifically suitable for underserved women and children. This OMEI + Nutrition will be conducted by the diversity supplement applicant, Dr. Brenda Abu, a Nutritionist-Researcher, who will add her strong nutrition and dietetics background to the already integrated health disparities research team. Dr. Abu enthusiastically intends to develop her career in the interaction of nutrition and oral health among the underserved population. This OMEI + Nutrition supplement will advance her skills and expertise in oral health and oral microbiome research, which will build a solid foundation for a future R01 application that assesses eating behavior and oral microbiome on maternal and children’s oral and systemic health.

项目摘要 早期儿童龋病(ECC)对来自低收入家庭的儿童和 少数民族社区。口腔微生物区系失调，包括致龋菌和 酵母菌，增加了ECC的风险。先前的研究表明，宫内和早期生命之间存在联系 营养摄入与肠道微生物群发育。然而，宫内和早期营养摄入对 孕妇和儿童的口腔微生物群仍不清楚。作为对家长奖的补充 R01DE031025早期婴幼儿口腔微生物组(OMEI)，我们建议补充OMEI+营养素。这个 家长OMEI通过一项有价值的服务不足的研究，研究了ECC种族差异背后的早期生物学因素 出生队列。在OMEI+营养补充剂中，我们将因素扩展到包括围产期营养素(如 饮食铁摄入量)和非营养行为(如异食癖)，以检查它们与口腔的潜在关系 孕期和生命早期的微生物群。 我们的中心假设是，有非营养性饮食行为的母亲与不同的 口腔微生物群落，影响儿童早期口腔微生物群的发育。我们建议 以下是OMEI+营养学研究的目标。目的1：评估营养和非营养饮食的效果 孕妇口腔微生物群行为的研究。目标2：评估母亲营养和营养的影响 婴幼儿早期(出生至6个月)非营养性饮食行为与口腔念珠菌定植和酵母菌 感染。目标3(探索性)：评估异食癖物质的微生物成分。 OMEI+营养学将是第一个研究营养与营养之间关系的研究 (如膳食铁摄入量)和非营养性因素(如PICA)对围产期口腔微生物群的影响 在服务不足的美国孕妇和她们的孩子中。产生的数据将加强 了解儿童口腔微生物群发育及其与ECC的关系。其他风险因素 由此揭示，OMEI+营养将被用作产前咨询、ECC早期预测和 预防，特别适用于服务不足的妇女和儿童。 这项OMEI+营养学将由多样性补充剂申请者布伦达·阿布博士进行，他是一名 营养学家兼研究员，她将在已经整合的基础上增加她强大的营养和营养学背景 健康差距研究团队。阿布博士热衷于在互动中发展她的职业生涯 服务不足人群的营养和口腔健康。这款OMEI+营养补充剂将推动 她在口腔健康和口腔微生物组研究方面的技能和专业知识，这将为 未来的R01应用程序，评估母婴口腔和儿童的饮食行为和口腔微生物群 全身性健康。