Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

从婴儿早期口腔微生物组了解儿童早期龋齿差异背后的生物因素

• 批准号: 10666930
• 负责人: STEVEN R. GILL
• 金额: $ 11.29万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10666930
• 关键词: Affect; Award; Behavior; Biological Factors; Birth; Child; Counseling; Data; Dental caries; Development; Dietary Iron; Dietetics; Eating Behavior; Exposure to; Foundations; Future; Health; Health Disparities Research; Household; Infant; Intake; Life; Low income; Mothers; Nutritionist; Oral; Oral candidiasis; Oral health; Parents; Perinatal; Pica Disease; Pregnancy; Pregnant Women; Prevention; Research; Research Personnel; Risk; Risk Factors; Solid; Underserved Population; Woman; Yeasts; career; cariogenic bacteria; cohort; dysbiosis; early childhood; early-life nutrition; ethnic minority; feeding; food insecurity; gut microbiome; in utero; infancy; microbial composition; microbiome research; minority communities; nutrition; oral microbial community; oral microbiome; oral supplementation; prenatal; racial and ethnic; racial disparity; skills; yeast infection

Project Summary Early childhood caries (ECC) disproportionately affects children from low-income households and ethnic minority communities. Dysbiosis of oral microbiota, including enrichment of cariogenic bacteria and yeast, increase the risk for ECC. Previous research indicated connections between in-utero and early-life nutrition intake and gut microbiome development. Yet, the impact of in-utero and early-life nutrition intake on maternal and children’s oral microbiome remains unclear. As an augmentation to the parent award R01DE031025 Oral Microbiome in Early Infancy (OMEI), we propose this supplement OMEI + Nutrition. The parent OMEI studies the early-life biological factors underlying ECC racial disparity via a valuable underserved birth cohort. In the OMEI+ Nutrition supplement, we expand the factors to include perinatal nutritive (such as dietary iron intake) and nonnutritive behavior (such as pica) to examine their potential relationships with oral microbiomes during pregnancy and early life. Our central hypothesis is that mothers with nonnutritive eating behavior are associated with a distinct oral microbial community, which influences oral microbiome development in early childhood. We propose the following aims in the OMEI + Nutrition study. Aim 1: Assess the effect of nutritive and nonnutritive eating behavior on the oral microbiome of pregnant women. Aim 2: Assess the impact of maternal nutritive and nonnutritive eating behavior on infants' early-life (birth to 6 months) oral Candida colonization and yeast infection. Aim 3 (Exploratory): assess microbial compositions of pica substances. The OMEI + Nutrition will be the first study that examines the relationship between nutritive (such as dietary iron intake) and nonnutritive (such as pica) factors on perinatal oral microbiome among underserved US pregnant women and their children. Data generated will strengthen the understanding of children’s oral microbiome development and their association to ECC. Additional risk factors revealed from this OMEI+ Nutrition would be used as targets for prenatal counselling, ECC early prediction and prevention, specifically suitable for underserved women and children. This OMEI + Nutrition will be conducted by the diversity supplement applicant, Dr. Brenda Abu, a Nutritionist-Researcher, who will add her strong nutrition and dietetics background to the already integrated health disparities research team. Dr. Abu enthusiastically intends to develop her career in the interaction of nutrition and oral health among the underserved population. This OMEI + Nutrition supplement will advance her skills and expertise in oral health and oral microbiome research, which will build a solid foundation for a future R01 application that assesses eating behavior and oral microbiome on maternal and children’s oral and systemic health.

项目概要 儿童早期龋齿 (ECC) 对低收入家庭的儿童和 少数民族社区。口腔微生物群失调，包括致龋细菌的富集和 酵母，增加 ECC 风险。先前的研究表明子宫内和早期生命之间的联系 营养摄入和肠道微生物群的发育。然而，子宫内和生命早期营养摄入对胎儿的影响 孕产妇和儿童的口腔微生物组仍不清楚。作为家长奖励的补充 R01DE031025 婴儿早期口腔微生物组 (OMEI)，我们建议使用这种补充剂 OMEI + 营养。这 母公司 OMEI 通过有价值的服务不足的研究，研究 ECC 种族差异背后的早期生物因素 出生队列。在OMEI+营养补充剂中，我们将因素扩展到包括围产期营养（例如 膳食铁摄入量）和非营养行为（例如异食癖），以检查它们与口腔的潜在关系 怀孕期间和生命早期的微生物组。 我们的中心假设是，母亲的非营养性饮食行为与独特的饮食习惯有关。 口腔微生物群落，影响幼儿期口腔微生物组的发育。我们建议 OMEI + 营养研究的以下目标。目标 1：评估营养性和非营养性饮食的效果 孕妇口腔微生物群的行为。目标 2：评估孕产妇营养和饮食的影响 非营养性饮食行为对婴儿早期（出生至 6 个月）口腔念珠菌定植和酵母菌的影响 感染。目标 3（探索性）：评估异食癖物质的微生物成分。 OMEI + Nutrition 将是第一个研究营养与营养之间关系的研究 （例如膳食铁摄入量）和非营养性（例如异食癖）因素对围产期口腔微生物组的影响 服务不足的美国孕妇及其子女。生成的数据将加强 了解儿童口腔微生物组的发育及其与 ECC 的关系。其他风险因素 此次揭示的OMEI+营养将作为产前咨询、ECC早期预测和 预防，特别适合服务不足的妇女和儿童。 本次 OMEI + Nutrition 将由多样性补充剂申请人 Brenda Abu 博士主持，他是一名 营养学家兼研究员，她将把她强大的营养和饮食学背景添加到已经整合的基础上 健康差异研究小组。 Abu 博士热衷于在与以下领域的互动中发展她的职业生涯： 服务不足人群的营养和口腔健康。这个OMEI+营养补充品会进步 她在口腔健康和口腔微生物组研究方面的技能和专业知识，将为她的口腔健康和口腔微生物组研究奠定坚实的基础。 未来的 R01 应用程序可评估孕产妇和儿童口腔的饮食行为和口腔微生物组 全身健康。