Measurement of surface lung tissue using ultrasound

使用超声波测量表面肺组织

• 批准号: 8936156
• 负责人: Xiaoming Zhang
• 金额: $ 38.07万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8936156
• 关键词: Appointment; Area; Biological Markers; Chest; Chest wall structure; Clinical; Clinical Research; Clinical assessments; Computer software; Data; Detection; Disease; Disease Progression; Dose; Enrollment; Evaluation; Fibrosis; Goals; High Resolution Computed Tomography; Interstitial Lung Diseases; Laboratories; Lead; Leg; Longitudinal Studies; Lung; Lung diseases; Measurement; Measures; Methods; Modification; Patients; Peripheral; Procedures; Property; Pulmonary Hypertension; Radiation; Reproducibility; Respiratory Failure; Role; Schedule; Severities; Severity of illness; Skin; Speed; Staging; Structure of parenchyma of lung; Surface; System; Systemic Scleroderma; Techniques; Testing; Translating; Ultrasonics; Ultrasonography; Work; arm; attenuation; base; clinical care; cohort; experience; follow-up; improved; innovation; meetings; mortality; novel; novel strategies; public health relevance; research clinical testing; response; screening; trend; vibration; viscoelasticity

 DESCRIPTION (provided by applicant): Interstitial lung disease (ILD) is an umbrella term for various lung disorders that are associated with dramatic changes in lung stiffness due to fibrosis of the lung parenchyma. ILD can lead to other complications, including pulmonary hypertension and respiratory failure. The ILD mortality rate has markedly increased in recent years, and this upward trend is expected to continue. High-resolution computed tomography (HRCT) is the clinical standard for assessing lung fibrosis, but it is expensive and associated with high doses of radiation that limit its use during follow-up. We have developed a noninvasive and nonionizing technique, lung surface wave elastometry (LSWE), that measures the viscoelasticity of superficial lung tissue with speed and accuracy. Our long-term goal is to establish a role for LSWE in routine clinical care because its quantitative measurement of lung viscoelastic properties can be used for sensitive evaluation of lung disease. The specific goals of this application are to evaluate LSWE in longitudinal clinical studies by measuring lung viscoelasticity and to demonstrate the clinical utility of LSWE for quantitative assessment of lung fibrosis. The rationale is that a safer and cheaper alternative to HRCT is needed because patients with ILD (especially early stage disease) need frequent follow-up to assess disease progression and response to treatment; LSWE has the potential to meet this need by reliably and sensitively assessing lung fibrosis without using invasive or ionizing techniques. The proposed work is significant because LSWE will improve clinical assessment of ILD. It also is innovative in its use of a novel surface wave ultrasonography technique to measure lung viscoelasticity and in the evaluation of its clinical utility in longitudinal studies of ILD. To acieve our goals, we propose 2 specific aims. In Aim 1, we will improve repeatability and reproducibility of LSWE measurements and assess the clinical utility of LSWE for evaluating lung fibrosis. We will determine whether the LSWE measurements are more sensitive than current clinical methods of assessing lung fibrosis. Aim 2 incorporates the LSWE technique into longitudinal clinical studies evaluating patients with ILD. We will study 1) whether LSWE provides sensitive data about lung stiffness changes for patients with lung fibrosis; 2) whether LSWE can assess response to therapies more accurately than current clinical methods; and 3) whether detection of subtle changes in lung viscoelasticity is more sensitive than current clinical methods of assessing the severity and course of lung fibrosis. We are confident that this project will be successful because of our feasible techniques and extensive clinical research experience. Upon successful completion of this project, we will have a novel, noninvasive, nonionizing, fast, and portable clinical technique for quantitatively assessing lung fibrosis.

 描述（由申请人提供）：间质性肺病（ILD）是各种肺部疾病的总称，这些疾病与由于肺实质纤维化导致的肺硬度的急​​剧变化相关。 ILD 可导致其他并发症，包括肺动脉高压和呼吸衰竭。近年来，ILD死亡率显着上升，并且预计这种上升趋势将持续下去。高分辨率计算机断层扫描（HRCT）是评估肺纤维化的临床标准，但其价格昂贵且与高剂量辐射相关，限制了其在随访期间的使用。我们开发了一种无创、非电离技术，即肺表面波弹性测量法 (LSWE)，可以快速、准确地测量浅层肺组织的粘弹性。我们的长期目标是确立 LSWE 在常规临床护理中的作用，因为它对肺粘弹性特性的定量测量可用于肺部疾病的灵敏评估。该应用的具体目标是通过测量肺粘弹性来评估纵向临床研究中的 LSWE，并证明 LSWE 在定量评估肺粘弹性方面的临床实用性 纤维化。理由是，需要一种更安全、更便宜的 HRCT 替代方案，因为 ILD 患者（尤其是早期疾病）需要频繁随访，以评估疾病进展和治疗反应； LSWE 有潜力通过可靠、灵敏地评估肺纤维化来满足这一需求，而无需使用侵入性或电离技术。拟议的工作意义重大，因为 LSWE 将改善 ILD 的临床评估。它的创新之处还在于使用新型表面波超声技术来测量肺粘弹性，并评估其在 ILD 纵向研究中的临床实用性。为了实现我们的目标，我们提出了 2 个具体目标。在目标 1 中，我们将提高 LSWE 测量的重复性和再现性，并评估 LSWE 在评估肺纤维化方面的临床效用。我们将确定 LSWE 测量是否比目前评估肺纤维化的临床方法更敏感。目标 2 将 LSWE 技术纳入评估 ILD 患者的纵向临床研究中。我们将研究1）LSWE是否为肺纤维化患者提供有关肺硬度变化的敏感数据； 2）LSWE是否能够比目前的临床方法更准确地评估治疗反应； 3）检测肺粘弹性的细微变化是否比目前评估肺纤维化严重程度和病程的临床方法更敏感。由于我们可行的技术和丰富的临床研究经验，我们相信这个项目将会成功。该项目成功完成后，我们将拥有一种新颖、无创、非电离、快速、便携式的临床技术来定量评估肺纤维化。