Mechanisms of immune homeostasis and regulation of intraocular inflammation
Mechanisms of immune homeostasis and regulation of intraocular inflammation
批准号:
9155560
负责人:
Charles E Egwuagu
金额:
$29.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Activated LymphocyteAreaAutoimmune DiseasesAutoimmune ProcessB-LymphocytesBiologic DevelopmentBiologyCD8-Positive T-LymphocytesCISH geneCell DeathCell ProliferationCellsChronicCommunicable DiseasesDevelopmentDiseaseEmbryonic DevelopmentEpigenetic ProcessEtiologyGoalsHomeostasisIFN consensus sequence binding proteinImmuneImmune systemImmunityInflammationInflammatoryInsectaInterleukinsLymphocyteMammalsNeurodegenerative DisordersPTPN6 genePathogenesisPathologicPathway interactionsPhysarum polycephalumPhysiological ProcessesPlayRegulationResearchRetinal DegenerationRoleSTAT3 geneSignal PathwaySignal TransductionSignal Transduction PathwayT-LymphocyteT-Lymphocyte SubsetsUveitisadaptive immunitybasecytokineinterestprotein inhibitors of activated STAT
中文摘要
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英文摘要
Our research focused on 3 broad themes: (i) Etiology and pathogenesis of ocular inflammatory diseases.
(ii) Development of Biologics for treating autoimmune diseases; (iii) T cell and cytokine biology: Contributions to basic mechanisms of host immunity. Significant advances in each of these areas include:
1. Discovery that Interleukin-35 induces regulatory B cells that suppress autoimmune disease.
2. Characterization of factors that underlie the development of chronic intraocular inflammation and retinal degenerative disease.
(3) Demonstration of the critical roles of IRF-8, STAT3, SOCS1, cytokines in the development and suppression uveitis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Interferon-inducible Transcription Factors: Roles In Ocu
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批准号:6507394
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
INTERFERON INDUCIBLE TRANSCRIPTION FACTORS: ROLES IN OCU
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批准号:6414669
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Development of dendritic cell vaccine against uveitis
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批准号:6968529
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Development of dendritic cell vaccine against uveitis
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批准号:7139194
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Role of IL-12 family cytokines in human autoimmune Uveit
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批准号:7321809
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Mechanisms of immune homeostasis and regulation of intraocular inflammation
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批准号:8339763
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项目类别:
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资助金额:$21.31万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Suppressors of Cytokine Signalling (SOCS) have Neuroprotective Roles in Retina
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批准号:8339752
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项目类别:
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资助金额:$16.39万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Suppressors of Cytokine Signalling (SOCS) have Neuroprotective Roles in Retina
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批准号:7594053
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项目类别:
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资助金额:$54.09万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Role of IL-12 family cytokines in human autoimmune Uveitis
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批准号:10019976
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项目类别:
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资助金额:$47.64万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Mechanisms of immune homeostasis and regulation of intraocular inflammation
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批准号:10019987
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项目类别:
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资助金额:$50.4万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Suppressors of Cytokine Signalling (SOCS) have Neuroprotective Roles in Retina
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批准号:10266869
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项目类别:
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资助金额:$11.7万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Development of Immunologic therapies against uveitis
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批准号:10266876
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项目类别:
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资助金额:$42.7万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Suppressors of Cytokine Signalling (SOCS) have Neuroprotective Roles in Retina
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批准号:10706095
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项目类别:
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资助金额:$14.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Regulation of JAK/STAT pathways in the eye
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批准号:10930499
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项目类别:
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资助金额:$53.89万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Development of Immunologic therapies against uveitis
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批准号:10930502
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项目类别:
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资助金额:$67.36万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Regulation of JAK/STAT pathways in the eye
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批准号:8149148
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项目类别:
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资助金额:$15.61万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Mechanisms of immune homeostasis and regulation of intra
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批准号:7322359
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Regulation of Cytokine Signaling Pathways in the Eye
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批准号:6432461
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Thymic Expression Of Ocular Proteins--Autoimmune Uveitis
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批准号:6826547
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
Role of STAT1 and SOCS in Dendritic cell Differentiation
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批准号:6826746
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles E Egwuagu
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依托单位:
国内基金
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层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
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批准号:2021JJ40433
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项目类别:省市级项目
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批准年份:2021
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2020
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负责人:段真珍
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依托单位:
AREA国际经济模型的移植.改进和应用
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批准号:18870435
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批准年份:1988
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负责人:史树中
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依托单位: