Development of a Neurovascular Magnetic Particle Imaging system with sub-millimeter resolution and real time speed for non-radiative 3D perfusion angiography

开发具有亚毫米分辨率和实时速度的神经血管磁粒子成像系统，用于非辐射 3D 灌注血管造影

• 批准号: 9049379
• 负责人: Patrick Goodwill
• 金额: $ 22.38万
• 依托单位: MAGNETIC INSIGHT, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9049379
• 关键词: Acute; Amplifiers; Aneurysm; Angiography; Animals; Biological Sciences; Biomedical Engineering; Blood Vessels; Brain; Brain Injuries; Businesses; Caliber; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Cerebral perfusion pressure; Clinical; Computer software; Contracts; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Discipline of Nuclear Medicine; Disease; Electrical Engineering; Electronics; Engineering; Equipment; Etiology; Evaluation; Fluoroscopy; Frequencies; Future; Goals; Grant; Health; Healthcare Systems; Human; Image; Imaging Techniques; Imaging technology; Industry; Iodine; Ionizing radiation; Iron; Kidney Diseases; Lead; Long-Term Care; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Measures; Mechanics; Mediation; Medical; Methods; Modality; Modeling; Monitor; Noise; Organ; Patients; Perfusion; Phase; Procedures; Protocols documentation; Radiation; Resistance; Resolution; Risk; Rotation; Safety; Sensitivity and Specificity; Signal Transduction; Small Business Innovation Research Grant; Speed; Staging; Stenosis; Stress Tests; Stroke; Stroke prevention; Structure; System; Techniques; Technology; Testing; Thallium Myocardial Perfusion Imaging Stress Test; Time; Tissues; Tracer; Ultrasonography; Vasospasm; Vendor; Venous Malformation; Weight-Bearing state; X-Ray Computed Tomography; acute stroke; animal imaging; cerebrovascular; cerebrovascular imaging; computer science; contrast imaging; cost; design; design and construction; imaging modality; imaging system; innovation; iron oxide; killings; magnetic field; malformation; member; millimeter; nanoparticle; new technology; particle; pre-clinical; prevent; professor; programs; prototype; reconstruction; response

 DESCRIPTION (provided by applicant): There is a clinical need for new neurovascular imaging techniques for the diagnosis, staging, and monitoring of acute stroke and sub-acute stenoses, arterial-venous malformations (AVMs), and aneurysms, among others. Together, these etiologies frequently manifest in acute stroke and kill over 130,000 people per year with an estimated cost the US healthcare system of over 36.5 billion dollars per year. A reliable and non-invasive neurovascular stress test, similar in concept to a cardiac stress test, would revolutionize cerebrovascular imaging and stroke prevention. It is well known that perfusion imaging, combined with a means of altering cerebral perfusion pressure or cerebrovascular resistance, can measure a patient's cerebrovascular reserve and predict the risk of stroke. Current neurovascular imaging techniques suffer from limitations in radiation exposure, safety, speed, sensitivity, and specificity that prevent their use in measuring cerebrovascular reserve. Magnetic particle imaging (MPI) is a new imaging technology that answers a clinical need for a safe, rapid 3D perfusion and 3D angiography technique without ionizing radiation or toxic tracers to image intracranial diseases such as stenosis (stroke), aneurysm, vasospasms and malformations. The MPI tracer is made with Iron Oxide (SPIO), significantly safer than Iodine (used in CT and fluoroscopy), and Gadolinum (used in MRI). The safe tracer and absence of harmful radiation leads to reduced long term medical costs for patient undergoing diagnostic angiography, and especially patients undergoing repeated diagnostic angiography procedures associated with long term care. MPI produces absolutely no signal from overlying tissues creating a positive contrast and quantitative angiography images or real time perfusion with unprecedented contrast to- noise and signal-to-noise. Successful completion of a human brain imager will mark the beginning of a new field of diagnostic imaging comparable in scope to the introduction of MRI, CT, or Ultrasound. This project aims to develop the first high resolution real time MPI system tailored for clinical cerebrovascular imaging. The proposed system will be the world's highest sensitivity and highest resolution tomographic MPI scanner. In Phase I of this SBIR, we will complete the main magnet design, build a 1/4 scale prototype, and develop our manufacturing plan. In Phase II we will construct the magnet and obtain phantom and animal images. In Phase III we will perform animal and then human testing

 描述（由适用提供）：临床需要进行新的神经血管成像技术，以诊断，分期和监测急性中风和亚急性stenose，伪像（AVMS）和动脉瘤等。这些病因共同出现在急性中风中，每年杀死13万人，估计每年超过365亿美元的美国医疗保健系统成本。可靠且无创的神经血管应激测试与心脏应激测试相似，将彻底改变脑血管成像和预防中风。众所周知，灌注成像结合了改变脑灌注压力或脑血管耐药性的方法，可以测量患者的脑血管储备并预测中风的风险。当前的神经血管成像技术受到辐射暴露，安全性，速度，灵敏度和特异性的限制，这些限制阻止了它们在测量脑血管储备中的使用。磁性颗粒成像（MPI）是一种新的成像技术，它可以回答对安全，快速3D灌注和3D血管造影技术的临床需求，而无需电离辐射或有毒的示踪剂，以形象颅内疾病，例如狭窄（Stenose）（streoke），动脉粥样硬化，动脉粥样硬化，血管疾病和畸形。 MPI示踪剂是用氧化铁（SPIO）制成的，比碘明显更安全（用于CT和荧光镜）和Gadolinum（用于MRI）。安全的示踪剂和缺乏有害辐射会导致患有诊断血管造影的患者长期医疗费用降低，尤其是接受与长期护理有关的诊断诊断血管造影程序的患者。 MPI绝对不会从上覆的组织产生信号，从而产生正面的对比度和定量血管造影图像或实时灌注，而与噪声和信噪比和信号噪声形成鲜明对比。成功完成人脑成像仪将标志着新的诊断成像领域的开始，其范围与MRI，CT或超声的引入范围相当。该项目旨在发展第一个高分辨率真实 针对临床脑血管成像量身定制的时间MPI系统。拟议的系统将是世界上最高的灵敏度和最高的分辨率层析成像MPI扫描仪。在此SBIR的第一阶段，我们将完成主磁铁设计，建立1/4比例原型，并制定我们的制造计划。在第二阶段，我们将构造磁铁并获得幻影和动物图像。在第三阶段，我们将进行动物，然后进行人体测试