Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform

超低失真和噪声电子器件支持临床 MPI 成像平台

• 批准号: 10761613
• 负责人: Patrick Goodwill
• 金额: $ 100.85万
• 依托单位: MAGNETIC INSIGHT, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761613
• 关键词: Air; Amplifiers; Anatomy; Animals; Applications Grants; Area; Brain; Categories; Cell Therapy; Cells; Classification; Climacteric; Clinical; Clinical Treatment; Complex; Coupling; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Electric Capacitance; Electronics; Engineering; Floor; Functional Imaging; Goals; Grant; Half-Life; Hemorrhage; Hemosiderin; Human; Image; Imaging Techniques; Imaging technology; Inflammation; Infrastructure; Institution; International; Magnetic Resonance Imaging; Magnetic nanoparticles; Magnetism; Marketing; Measurement; Measures; Medical Imaging; Medicine; Modality; Modernization; Molecular; Monitor; Noise; Pathology; Performance; Phase; Physics; Physiologic pulse; Physiological; Positron-Emission Tomography; Pre-Clinical Model; Radioactive; Radioactive Tracers; Resolution; Roentgen Rays; Role; Safety; Scientist; Shipping; Signal Transduction; Small Business Innovation Research Grant; Speed; Structure; System; Techniques; Technology; Testing; Tissues; Tracer; Visualization; Work; cellular imaging; clinical diagnosis; clinical imaging; commercialization; contrast imaging; design; human imaging; imager; imaging modality; imaging platform; imaging system; improved; innovation; insight; instrument; magnetic field; nano; new technology; nuclear imaging; particle; pre-clinical; prototype; research clinical testing; single photon emission computed tomography; stem cells; tool; transmission process; ultrasound; voltage

SUMMARY/ABSTRACT In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogenous contrast imaging. Our overall approach is to improve sensitivity and resolution by minimizing distortion, adding transmit/receive channels, decoupling, improving preamplifiers, and developing new pulse sequences. MPI is an emerging molecular and tracer imaging technology that directly detects magnetic nanoparticles (MNPs) with high sensitivity at mm-scale resolutions. MPI images are direct views of tracer distribution with no signal arising from tissue, no perturbations from materials such as air, and image intensity directly linear with tracer concentration. This “hot-spot” contrast provides spatial localization and quantification without ambiguity. MPI’s contrast is similar to nuclear medicine but without the workflow, safety, and half-life limitations of a radioactive tracer. MPI has many applications in the brain and body, as demonstrated by our customers in small animals. Despite significant efforts by multiple institutions, the lack of a clinical MPI scanner remains a significant limitation for the technique. In this Direct to Phase II SBIR proposal, we will advance the medical imaging field by building the world’s first general-purpose clinical MPI scanner to serve the myriad applications our customers are testing on our preclinical instrument. We will design and implement a new transmit/receive subsystem and install it in our prototype scanner to achieve the performance necessary for clinical imaging applications. This new transmit/receive subsystem includes the following innovations that push our sensitivity from our current rough prototype to near the physics limit through the following specific aims: Aim 1. Drive transmit distortion and the noise floor to the physics limit for a one-channel Tx/Rx coil Aim 2. Design a clinical multi-channel transmit and receive subsystem Aim 3. Develop new acquisition pulse sequences to improve sensitivity, resolution, and speed

总结/摘要 在这项SBIR资助提案中，“超低失真和噪声电子器件，以实现临床MPI成像平台”， 我们将开发用于临床磁粒子成像（MPI）平台的RF子系统，以实现三个类别 MPI的应用：细胞跟踪，功能成像，和内源性造影成像。我们的总体方法是 通过最小化失真、增加发射/接收通道、去耦 改进前置放大器和开发新的脉冲序列。 MPI是一种新兴的分子和示踪剂成像技术，可直接检测磁性纳米颗粒 （MNP）在毫米级分辨率下具有高灵敏度。MPI图像是示踪剂分布的直接视图， 来自组织的信号，没有来自诸如空气的材料的扰动，并且图像强度与 示踪剂浓度这种“热点”对比提供了空间定位和量化而没有歧义。 MPI的造影剂类似于核医学，但没有常规造影剂的工作流程、安全性和半衰期限制。 放射性示踪剂。MPI在大脑和身体中有许多应用，正如我们的客户在小型 动物尽管多个机构做出了重大努力，但缺乏临床MPI扫描仪仍然是一个重大问题。 技术的局限性。 在这个直接进入第二阶段的SBIR提案中，我们将通过建立世界上 第一个通用临床MPI扫描仪，服务于我们的客户正在测试的无数应用程序， 临床前仪器我们将设计和实现一个新的发射/接收子系统，并将其安装在我们的 原型扫描仪，以实现临床成像应用所需的性能。这个新 发射/接收子系统包括以下创新，将我们的灵敏度从目前的粗糙 通过以下具体目标使原型接近物理极限： 目标1。将发射失真和本底噪声驱动到单通道Tx/Rx线圈的物理极限 目标2.设计了一种临床多通道收发子系统 目标3。开发新的采集脉冲序列以提高灵敏度、分辨率和速度