Exposure Assessment, Biomarkers and Metabolomics FC

暴露评估、生物标志物和代谢组学 FC

• 批准号: 8830361
• 负责人: CHRISTOPHER D SIMPSON
• 金额: $ 13.86万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8830361
• 关键词: Biological; Biological Assay; Biological Markers; Chemical Agents; Chemicals; Collection; Consultations; Core Facility; Data; Disease; Dose; Environment; Environmental Health; Epidemiologic Studies; Exposure to; Failure; Goals; Health; Health Sciences; Human; Individual; Lead; Mass Spectrum Analysis; Measurement; Measures; Metals; Mission; Occupational; Outcome; Particulate; Play; Population; Probability; Process; Public Health; Research Personnel; Risk; Risk Assessment; Role; Sampling; Services; Tissues; base; gene environment interaction; metabolomics; response; tool; uptake; volatile organic compound; wasting

Exposure assessment is the process of characterizing human contact with and uptake of agents from the environment (including the occupational environment). Given a particular agent, accurate quantification of exposure is critical for epidemiological studies that seek to define dose-response relationships and for risk assessment studies that quantify the probability of a harmful effect to exposed individuals or populations. Misclassification of exposure can lead to failure to adequately protect public health if the risk of harm is underestimated. Alternatively, if the health risk posed by a specific agent is overestimated due to inaccurate measures of exposure, scarce public health dollars are wasted needlessly. The overarching mission of EABM-FC is to provide state-of-the-art exposure assessment tools to CEEH investigators in order to reliably quantify exposure to agents in the environmental and subsequent health consequences and understand the role that gene-environment interactions play in modulating health outcomes.

暴露评估是确定人类与环境(包括职业环境)的接触和从环境(包括职业环境)吸收制剂的特征的过程。对于寻求确定剂量-反应关系的流行病学研究和量化对暴露个人或人群产生有害影响的可能性的风险评估研究来说，给定特定的制剂，准确量化暴露的数量是至关重要的。 如果低估了危害风险，对接触的错误分类可能会导致无法充分保护公众健康。或者，如果由于不准确的暴露测量而高估了某一特定因素带来的健康风险，那么稀缺的公共卫生资金就会被不必要地浪费掉。 EABM-FC的首要使命是向CEEH调查人员提供最先进的暴露评估工具，以便可靠地量化暴露于环境和随后的健康后果中的制剂，并了解基因-环境相互作用在调节健康结果中所起的作用。