Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center

 描述（申请人提供）：匹兹堡临床中心（PCC）是匹兹堡大学和UPMC的临床转化项目，旨在对复发性急性胰腺炎（RAP）和慢性胰腺炎（CP）以及增加儿童和成人纤维化，疼痛和胰源性糖尿病（T3cDM）风险的因素进行研究。和胰腺导管腺癌（PDAC）的风险。匹兹堡大学和UPMC的多学科团队被组织起来参与胰腺疾病患者的综合临床，流行病学和生物学特征， 明确RAP和CP的病理生理机制及其后遗症。提出了三个具体目标：目标1。开发集成的临床中心核心流程，以促进数据和生物样本管理，最大限度地提高沟通和评估新技术。目标2.建立明确CP演变过程中患者的纵向研究队列模型。目标3.生成并测试一个框架，以分析影响RAP进展的风险因素，可能的CP和明确的CP，以及监测疾病状态和终点的临床有用的生物标志物。我们现有的完善、高效和有效的临床基础设施，包括患者招募、样本处理、疾病进展评估、数据管理和分析，将为该计划提供支持。丰富的临床卷，在所有关键领域的专家医师表型，流行病学，遗传学，生理学，细胞生物学，成像，生物统计学和生物信息学，以及所有相关疾病亚型的领导地位，加上成人和儿童临床和研究领域的行政权威，确保持续的成功。PCC教师与其他大学许多优秀项目的密切合作和工作关系的历史也将为国家联盟提供动力。

 DESCRIPTION (provided by applicant): Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies on recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and factors that increase the risk of fibrosis, pain, and pancreatogenic diabetes (T3cDM) in children and adults, and risk of pancreatic ductal adenocarcinoma (PDAC) in adults with CP and/or DM. Multi-disciplinary teams at the University of Pittsburgh and UPMC are organized to participate in comprehensive clinical, epidemiological and biological characterization of patients with pancreatic disorders and to define the pathophysiology of RAP & CP and their sequela. Three specific aims are proposed: Aim 1. To develop integrated clinical center core processes to facilitate data and biosample management, to maximize communication and to evaluate of new technologies. Aim 2. To establish a model longitudinal research cohort of patients during evolution of definite CP. Aim 3. To generate and test a framework to analyze risk factors affecting the progression of RAP, probable CP and definite CP, and clinically useful biomarkers to monitor disease state and endpoints. Our existing and well-established, efficient and effective clinical infrastructure for patient accrual, sample processing, disease progression assessment, data management and analysis will support the program. The rich clinical volume, expert physician phenotypers in all critical areas, established leadership in epidemiology, genetics, physiology, cell biology, imaging, biostatistics and bioinformatics, and all relevant disease subtypes, plus administrative authority in clinical and research areas for both the adult and children ensure continued success. The history of strong collaborations and working relationships of the PCC faculty with many outstanding programs at other universities will also provide momentum to the national consortium.