Interdisciplinary Training in Movement Disorders and Neurorestoration

运动障碍和神经恢复的跨学科培训

• 批准号: 8853371
• 负责人: Dawn Bowers
• 金额: $ 16.18万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8853371
• 关键词: Movement Disorders; Training; neurorestoration

 DESCRIPTION (provided by applicant): Movement disorders such as Parkinson's disease, dystonia, and ataxia strip away the ability to act on our environment. Each disease causes unwanted movements, makes desired movements more difficult to perform, and also affects how we think and process our emotions. To be effective, research into movement disorders must cross disciplines, and enhance the translation of basic science discoveries to help humans move more effectively. This Movement Disorders and Neurorestoration Training (MDNR) program confronts this problem head on by bringing together an outstanding group of mentors with a rich infrastructure and resources to train predoctoral Trainees focused on movement disorders. This program combines a critical mass of well-trained scientists prepared to conduct research focused on the ABC'S of translational research: an etiology, biomarkers/end phenotypes, and causative and symptom based therapies. To do so, the program will encompass three areas with a central theme of movement disorders: a) molecular biology and animal models; b) translational neuroscience and physiology, and c) human motor and cognitive neuroscience. Specific approaches within these themes can range from genetics to molecular to neuroimaging to neurorestoration to behavioral, but the central focus is movement disorders. Trainees are selected from a pool of outstanding students with diverse backgrounds and are admitted by one of five graduate programs. A key feature is that Trainees experience laboratories that cross areas, and dissertation committee members must come from each of the three scientific areas. The MDNR program capitalizes on existing strengths and strategic investments at the University of Florida (UF) including well-established investigators in ataxia, Parkinson's disease, atypical parkinsonism, and dystonia, outstanding animal research facilities for basic science, world class animal and human imaging facilities, three privately endowed and foundation supported Centers of Excellence for Parkinson's disease, dystonia, and ataxia, and the UF Center for Movement Disorders and Neurorestoration. This patient-centered clinical research facility maintains the largest, comprehensive clinical research database in the world. Upon entering the program, each trainee prepares an individualized career development plan that consists of a structured didactic program, specialized courses, seminars, and laboratory research. The mentor to mentor interaction that crosses levels of analysis sets up a unique learning environment that will prepare Trainees for a strong future as biomedical scientists that can make a difference in movement disorders. This training program in Movement Disorders and Neurorestoration provides an interdisciplinary training environment that is fundamental to the advancement of research in the etiology and treatment of movement disorders.

 描述（由申请人提供）：运动障碍，如帕金森氏病，肌张力障碍和共济失调剥夺了对我们环境的作用能力。每种疾病都会导致不必要的动作，使想要的动作更难执行，也会影响我们思考和处理情绪的方式。为了有效，对运动障碍的研究必须跨学科，并加强基础科学发现的转化，以帮助人类更有效地运动。这个运动障碍和神经恢复训练（MDNR）计划通过汇集一群优秀的导师，拥有丰富的基础设施和资源来培训专注于运动障碍的博士前学员，从而直面这个问题。该计划结合了训练有素的科学家准备进行研究的关键质量专注于转化研究的ABC：病因学，生物标志物/最终表型，以及基于病因和症状的治疗。为此，该计划将包括三个领域的运动障碍的中心主题：a）分子生物学和动物模型; B）转化神经科学和生理学，以及c）人类运动和认知神经科学。这些主题中的具体方法可以从遗传学到分子到神经成像到神经恢复到行为，但中心焦点是运动障碍。学员是从具有不同背景的优秀学生中挑选出来的，并被五个研究生课程之一录取。一个关键的特点是，实习生体验跨领域的实验室，论文委员会成员必须来自三个科学领域。MDNR计划利用了佛罗里达大学（UF）的现有优势和战略投资，包括共济失调，帕金森病，非典型帕金森症和肌张力障碍的成熟研究人员，基础科学的杰出动物研究设施，世界一流的动物和人类成像设施，三个私人捐赠和基金会支持的帕金森病，肌张力障碍和共济失调卓越中心，和UF运动障碍和神经恢复中心。这家以患者为中心的临床研究机构拥有世界上最大、最全面的临床研究数据库。进入该项目后，每位学员都会准备一份个性化的职业发展计划，其中包括结构化的教学计划、专业课程、研讨会和实验室研究。跨层次分析的导师与导师的互动建立了一个独特的学习环境，这将为学员作为生物医学科学家的强大未来做好准备，这些生物医学科学家可以在运动障碍方面发挥作用。运动障碍和神经恢复的培训计划提供了一个跨学科的培训环境，这是运动障碍病因学和治疗研究进步的基础。