Emotion Regulation, Executive Function, and Parkinson Disease

情绪调节、执行功能和帕金森病

• 批准号: 8470737
• 负责人: Dawn Bowers
• 金额: $ 17.67万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8470737
• 关键词: Address; Affect; Amygdaloid structure; Anxiety; Arousal; Attention; Blinking; Clinical; Cognitive; Comorbidity; Complex; Descriptor; Disease; Elderly; Electroencephalography; Emotional; Emotions; Event-Related Potentials; Exhibits; Failure; Generations; Goals; Health; Husband; Impaired cognition; Impairment; Instruction; Intervention; Learning; Light; Measures; Mental Depression; Modeling; Motor; National Institute of Mental Health; Neurocognitive; Neurodegenerative Disorders; Parkinson Disease; Participant; Patients; Pharmaceutical Preparations; Physiological; Process; Psychophysiology; Regulation; Reporting; Research; Semantics; Severities; Severity of illness; Stimulus; Structure; Subgroup; Symptoms; System; Techniques; Testing; Up-Regulation; Woman; Work; base; emotion regulation; emotional stimulus; executive function; improved; indexing; meetings; neuropsychiatry; response; showing emotion; social; success; theories

DESCRIPTION (provided by applicant): The overarching goal of the current project is increased understanding of emotional processes in Parkinson's disease. Parkinson's disease (PD) is one of the most common neurodegenerative disorders of late life. It is caused by progressive dopaminergic depletion with motor, cognitive, and emotional changes. While advances have been made with respect to motor symptoms, emotional and neuropsychiatric changes (depression, apathy, anxiety) are prevalent and can be the some of the most disturbing, disabling, and complex aspects of the disorder. Findings from four recent studies of emotional responding have found that non-demented Parkinson patients without psychiatric co-morbidities exhibited blunted physiologic reactivity to aversive pictures as indexed by the startle eyeblink response (Bowers et al., 2006; Miller et al., 2009; Zahodne et al., 2011) or an event related potential component of motivated attention, the late positive potential, LPP (Dietz et al., 2011a). This reduced reactivity to unpleasant stimuli was not due to medication, depression, perceptual difficulties, or failure to generate basic startle or electrocortical activity. One interpretation of this emotional blunting relates to dopaminergic gating and inhibition of the amygdala, a key limbic structure in the emotion processing cascade. In light of these findings, the aims of the present study are to learn whether Parkinson patients can upregulate their responses to emotional stimuli and whether success in doing so is related to integrity of frontal-executive function. To address this aim, two approaches for amplifying emotional reactivity will be taken, one that is more active and self-directed (auto-evoked) and another that is more passive (exo-evoked). Both approaches have been associated with increased physiologic reactivity in healthy controls, as indexed by electrocortical responses (Moser et al., 2009, 2010; Foti & Hajcak, 2008; McNamara et al., 2009). In the current research, non-demented, non-depressed Parkinson patients and healthy controls will participate in two separate studies. Parkinson patients will be psychometrically classified into two cognitive subgroups based on neurocognitive measures: executively impaired (PD-exec) and cognitively normal (PD). During testing, participants will view standardized sets of neutral and emotional pictures while startle eyeblink responses and EEG are recorded. One study will involve use of self-directed regulation strategies to increase reactivity to emotional pictures, and the other study will involve passive listening to narratives that alter subsequent semantic meaning. Primary dependent variables will be amplitude of LPP, startle eyeblink and verbal ratings of valence and arousal. The major hypothesis is that effective regulation of physiologic reactivity to emotional stimuli by PD patients will depend on the integrity of frontal-executive systems. Parkinson patients in the cognitively normal subgroup will show changes in emotional reactivity regardless of active or more passive regulation approaches, whereas PD patients with executive disturbance will benefit only in the passive condition. Relationship to disease variables and neuropsychiatric factors (apathy, anxiety) will be examined. The proposed research will be the first to test whether Parkinson patients can benefit from techniques for bolstering their physiological and emotional reactivity. If predictions are met, the obtained findings may have broad implications for emotional enhancement in Parkinson disease.

描述（由申请人提供）：当前项目的总体目标是增加对帕金森病情绪过程的理解。帕金森病（PD）是最常见的老年神经退行性疾病之一。它是由运动、认知和情绪变化引起的进行性多巴胺能耗竭引起的。虽然在运动症状方面取得了进展，但情绪和神经精神方面的变化（抑郁、冷漠、焦虑）很普遍，可能是该疾病最令人不安、致残和最复杂的方面。最近四项关于情绪反应的研究发现，没有精神合并症的非痴呆帕金森患者对令人厌恶的图片表现出迟钝的生理反应，以惊吓为指标