Engineering Bioresponsive Hybrid Nanodevices using RNA, Peptides and Synthetic Polymers

使用 RNA、肽和合成聚合物工程生物响应混合纳米器件

• 批准号: FT140100873
• 负责人: Dr Francesca Cavalieri
• 金额: $ 53.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-06-08 至 2019-08-07
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100873
• 关键词: Engineering; Bioresponsive; Hybrid; Nanodevices; using

This project aims to develop new microRNA polymer nanoassemblies with enhanced bioresponsive properties. Nanoengineered functional RNA-polymer materials can exploit both the recognition properties of RNA and the responsiveness of the polymer to tailor the structural and physicochemical properties of such systems. Further, targeting ligands (antibody, aptamers) tethered to the RNA-polymer nanoassembly could augment cellular uptake and delivery. The development of imaging and tracking methodology to accurately measure intracellular miRNA payload and localisation in a 3D tissue mimicking matrix is also planned.

该项目旨在开发具有增强生物响应特性的新型microRNA聚合物纳米组装体。纳米工程化的功能性RNA聚合物材料可以利用RNA的识别特性和聚合物的响应性来定制此类系统的结构和物理化学特性。此外，与RNA-聚合物纳米组装体连接的靶向配体（抗体、适体）可以增加细胞摄取和递送。还计划开发成像和跟踪方法，以准确测量细胞内miRNA有效载荷和3D组织模拟矩阵中的定位。