Engineering Bioresponsive Hybrid Nanodevices using RNA, Peptides and Synthetic Polymers

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This project aims to develop new microRNA polymer nanoassemblies with enhanced bioresponsive properties. Nanoengineered functional RNA-polymer materials can exploit both the recognition properties of RNA and the responsiveness of the polymer to tailor the structural and physicochemical properties of such systems. Further, targeting ligands (antibody, aptamers) tethered to the RNA-polymer nanoassembly could augment cellular uptake and delivery. The development of imaging and tracking methodology to accurately measure intracellular miRNA payload and localisation in a 3D tissue mimicking matrix is also planned.