Engineering Bioresponsive Hybrid Nanodevices using RNA, Peptides and Synthetic Polymers

该项目旨在开发具有增强生物响应性的新型microRNA聚合物纳米组件。纳米工程功能RNA-聚合物材料可以利用RNA的识别特性和聚合物的响应性来定制此类系统的结构和物理化学性质。此外，与RNA聚合物纳米组装相连的靶向配体(抗体、适配子)可以增强细胞的摄取和传递。还计划开发成像和跟踪方法，以准确测量细胞内miRNA的有效载荷和在3D组织模拟基质中的定位。

This project aims to develop new microRNA polymer nanoassemblies with enhanced bioresponsive properties. Nanoengineered functional RNA-polymer materials can exploit both the recognition properties of RNA and the responsiveness of the polymer to tailor the structural and physicochemical properties of such systems. Further, targeting ligands (antibody, aptamers) tethered to the RNA-polymer nanoassembly could augment cellular uptake and delivery. The development of imaging and tracking methodology to accurately measure intracellular miRNA payload and localisation in a 3D tissue mimicking matrix is also planned.