Synergistic interactions between SapC-DOPS and chemotherapy for glioma

SapC-DOPS 与胶质瘤化疗之间的协同相互作用

• 批准号: 8648398
• 负责人: Jeffrey A. Wojton
• 金额: $ 0.81万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-03 至 2014-05-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8648398
• 关键词: American Cancer Society; Apoptosis; Apoptotic; Blood; Brain; Brain Neoplasms; Caspase; Cell membrane; Cells; Ceramides; Cessation of life; Charge; Contrast Media; Coupled; Data; Fluorescent Probes; Future; Glioblastoma; Glioma; Glycosphingolipids; Goals; In Vitro; Induction of Apoptosis; Intravenous; Magnetic Resonance; Malignant Neoplasms; Modality; Patients; Phosphatidylserines; Phospholipids; Proteins; Research; Signal Transduction; Specificity; Sphingolipids; Surface; Treatment Efficacy; Tumor Tissue; acid sphingomyelinase; base; beta-Glucosidase Stimulating Protein; cancer cell; chemotherapy; efficacy testing; in vivo; irradiation; killings; nanotherapeutic; nanovesicle; neoplastic cell; public health relevance; temozolomide; tumor

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to test the efficacy of SapC-DOPS: a unique targeting nanotherapeutic for brain tumors, in combination with chemotherapy. Saposin C (SapC) is a sphingolipid activating protein found ubiquitously throughout the body that functions to catabolize glycosphingolipids. SapC preferentially associates with negatively charged phospholipids at an acidic pH. When SapC is coupled with dioleoylphosphatidylserine (DOPS), stable nanovesicles are formed which can selectively fuse with cancer cells, leading to activation of acid sphingomyelinase and subsequent ceramide accumulation, caspase activation, and eventual apoptosis. In this proposal we seek to investigate any synergistic interactions between SapC-DOPS and chemotherapy, which has broad implications on the future treatment paradigms for glioma and other cancers as well.

描述（由申请人提供）：本提案的长期目标是测试SapC-DOPS的疗效：SapC-DOPS是一种独特的靶向脑肿瘤纳米治疗药物，与化疗联合使用。皂苷C （SapC）是一种鞘脂激活蛋白，在体内无处不在，其功能是分解鞘脂糖。在酸性环境下，SapC优先与带负电荷的磷脂结合。当SapC与二油基磷脂酰丝氨酸（DOPS）结合时，形成稳定的纳米囊泡，可以选择性地与癌细胞融合，导致酸性鞘磷脂酶的激活和随后的神经酰胺积累、半胱氨酸酶的激活，最终导致细胞凋亡。在本研究中，我们试图研究SapC-DOPS与化疗之间的协同作用，这对未来胶质瘤和其他癌症的治疗模式具有广泛的意义。

项目成果

Response to "Right Analysis-Wrong Conclusion: Obese Youth With Higher BP Are at Risk for Target Organ Damage".

回应“正确的分析 - 错误的结论：血压较高的肥胖青少年面临靶器官损伤的风险”。

• DOI: 10.1093/ajh/hpv085
• 发表时间: 2015
• 期刊: American journal of hypertension
• 影响因子: 3.2
• 作者: Schwandt,Peter;Scholze,JuergenE;Bertsch,Thomas;Ecotroph,EvelynL;Haas,GerdaM
• 通讯作者: Haas,GerdaM

Risk factors and the outcome of therapy in patients with seizure after Carbamazepine poisoning: A two-year cross-sectional study.

卡马西平中毒后癫痫发作患者的危险因素和治疗结果：一项为期两年的横断面研究。

• DOI: 10.4103/2279-042x.150046
• 发表时间: 2015
• 期刊: Journal of research in pharmacy practice
• 影响因子: 1
• 作者: Yaraghi,Ahmad;Eizadi-Mood,Nastaran;Salehi,Marzieh;Massoumi,Gholamreza;Zunic,Lejla;Sabzghabaee,AliMohammad
• 通讯作者: Sabzghabaee,AliMohammad