Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer’s disease risk.

人类诱导多能干细胞的异构体依赖性 apoE 加工。

• 批准号: nhmrc : 1079995
• 负责人: A/Pr Kuldip Sidhu
• 金额: $ 28.64万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/isoform-dependent-apoe-disease-risk/518715
• 关键词: Isoform; dependent; apoE; processing; human

We recently discovered that a protein called apoE is cleaved in the brain to generate a small fragment that may have neuroprotective properties. We also discovered that human induced pluripotent stem cell (iPSC)-derived neurons produce apoE fragments identical to those in the brain. We will now characterise iPSC apoE and assess its neuroprotective properties. This will resolve the basis for the association of apoE with AD risk and potentially provide a new target for AD treatment.

我们最近发现，一种名为apoE的蛋白质在大脑中被切割，产生一个可能具有神经保护作用的小片段。我们还发现，人类诱导多能干细胞（iPSC）衍生的神经元产生与大脑中相同的apoE片段。我们现在将检测iPSC apoE并评估其神经保护特性。这将解决apoE与AD风险相关的基础，并可能为AD治疗提供新的靶点。