PROJECT 9. Biostatistics SRF

项目 9. 生物统计学 SRF

• 批准号: 8740639
• 负责人: Heidi L Weiss
• 金额: $ 16.26万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8740639
• 关键词: Address; Animals; Applications Grants; Bioinformatics; Biometry; Biostatistics Shared Resource; Cancer Center; Cancer Center Support Grant; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Complex; Consultations; Data; Data Analyses; Data Collection; Data Quality; Databases; Development; Educational process of instructing; Ensure; Faculty; Goals; Human Resources; In Vitro; Informatics; Intervention Studies; Kentucky; Laboratories; Malignant Neoplasms; Manuscripts; Mentors; Methodology; Mission; Monitor; Phase; Play; Preparation; Quality Control; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Role; Safety; Sample Size; Sampling; Science; Secure; Services; Staging; Toxic effect; Training; Universities; abstracting; analytical method; anticancer research; computerized data processing; data management; design; experience; in vivo; member; mouse model; neoplasm registry; population based; pre-clinical; preclinical study; programs; research study

The Biostatistics Shared Resource Facility (BSRF) is a Markey Cancer Center (MCC)-managed resource providing comprehensive and centralized support that is readily accessible to cancer center investigators. The specific aims of the BSRF encompass support during study planning and study conduct and at the final stage of each project. In order to achieve these aims, our services are categorized broadly into: 1) study planning, power, and sample size calculations for grant applications, clinical trials, population-based studies, and preclinical experiments; 2) statistical analyses, including interim and final analysis for the entire spectrum of cancer research studies; 3) statistical programming for data quality control and data processing; and 4) mentoring, teaching, and general consultation to MCC investigators. We also collaborate closely with MCC's Clinical Research and Data Management SRF, Cancer Research Informatics SRF, and other MCC shared facilities. The shared resource personnel include six faculty statisticians, two master's-level statisticians, and a faculty bioinformatician. Collectively, they have extensive cancer-specific experience, expertise, and ongoing collaborations with investigators involved in studies ranging from laboratory, in vitro, in vivo studies in mouse models of cancer, translational, and bioinformatics studies in clinical samples, clinical trials, and population-based intervention studies. BSRF personnel are highly integrated with investigators across all research programs and interact closely with other SRFs at MCC to ensure comprehensive and seamless support. With personnel who are well-versed in all aspects of the biostatistical needs of MCC investigators, the dedicated BSRF team adds significant value to the conduct of research at the MCC.

生物统计共享资源设施（BSRF）是Markey癌症中心（MCC）管理的资源，提供全面和集中的支持，癌症中心研究人员可以随时访问。BSRF的具体目标包括在研究规划和研究实施期间以及每个项目的最后阶段提供支持。为了实现这些目标，我们的服务大致分为：1）资助申请、临床试验、基于人群的研究和临床前实验的研究规划、把握度和样本量计算; 2）统计分析，包括整个癌症研究范围的中期和最终分析; 3）数据质量控制和数据处理的统计编程; 4）对MCC调查人员进行指导、教学和一般咨询。我们还与MCC的临床研究和数据管理SRF，癌症研究信息SRF和其他MCC共享设施密切合作。共享资源人员包括六名教师统计学家，两名硕士级统计学家和一名教师生物信息学家。总的来说，他们拥有广泛的癌症特异性经验，专业知识，并与参与研究的研究人员进行持续合作，研究范围包括实验室，体外，小鼠癌症模型的体内研究，临床样本的翻译和生物信息学研究，临床试验和基于人群的干预研究。BSRF人员与所有研究项目的研究人员高度融合，并与MCC的其他SRF密切互动，以确保全面和无缝的支持。BSRF的专业团队拥有精通MCC研究人员生物统计需求各个方面的人员，为MCC的研究工作增添了重要价值。