Biostatistics and Data Management

贝勒医学院淋巴瘤 SPORE 的生物统计核心将提供全面的 以及整合该 SPORE 中研究项目的生物统计活动的集中支持 程序。 该核心的具体目标是： 1. 协调和管理 SPORE 的统计活动，以确保调查人员 随时获得生物统计咨询； 2. 提供研究计划和临床试验及临床前实施方面的生物统计学专业知识 验证实验； 3. 与临床核心密切合作，协调数据管理活动；和 4. 为安全/毒性监测、中期数据分析等数据分析提供全面支持 数据审查、最终分析和报告。 该淋巴瘤 SPORE 应用提出了迭代实验室临床研究，其中需要科学和 随后的动物实验和临床试验的统计输入。生物统计核心人员将 将合理的实验原则纳入研究计划和开发中，实施协调的数据 管理系统，便于提供及时、高质量的统计分析和数据 解释。该 SPORE 应用程序的生物统计核心将得到现有成员的支持 贝勒癌症中心的生物统计共享资源经验丰富，并已建立 与该 SPORE 的研究成员的合作。最终，SPORE 调查员在这 应用程序将受益于生物统计核心的基础设施，以确保实施 创新和高质量的转化研究。

The Biostatistics Core for the Baylor College of Medicine's Lymphoma SPORE will provide comprehensive and centralized support that integrates the biostatistical activities of the research projects in this SPORE program. The specific aims of this core are to: 1. coordinate and manage the statistical activities of the SPOREto ensure that investigators have ready access to biostatistical consultation; 2. provide biostatistical expertise in study planning and conduct of clinical trials and preclinical validation experiments; 3. coordinate data management activities in close collaborationwith the Clinical Core; and 4. provide comprehensive support for data analysis including safety/toxicity monitoring, interim reviews of data, final analysis, and reporting. This Lymphoma SPORE application proposes iterative laboratory-clinical studies which entails scientific and statistical input for the ensuing animal experiments and clinical trials. The Biostatistics Core personnel will incorporate sound experimental principles in study planning and development, implement a coordinated data management system, and facilitate provision of timely and high-quality statistical analysis and data interpretation. The Biostatistics Core of this SPORE application will draw support from existing members of Baylor Cancer Center's Biostatistics Shared Resource who are highly experienced and have established collaborations with the research members of this SPORE. Ultimately, the SPORE investigators in this application will benefit from the infrastructure of the Biostatistics Core to ensure the implementation of innovative and high-quality translational studies.