Biostatistics and Data Management

生物统计学核心为贝勒医学院的淋巴瘤孢子提供全面的 以及整合本孢子研究项目的生物统计活动的集中支助 程序。 这一核心的具体目标是： 1.协调和管理特别委员会的统计活动，以确保调查员 随时可以获得生物统计咨询； 2.在临床试验和临床前研究的规划和实施方面提供生物统计学专业知识 验证实验； 3.与临床核心密切合作，协调数据管理活动；以及 4.为数据分析提供全面支持，包括安全/毒性监测、临时 数据回顾、最终分析和报告。 这种淋巴瘤孢子的应用提出了反复的实验室-临床研究，这需要科学和 为随后的动物实验和临床试验输入统计数据。生物统计核心人员将 在研究计划和开发中纳入合理的实验原则，实施协调的数据 管理系统，并促进提供及时和高质量的统计分析和数据 释义。这个孢子应用程序的生物统计核心将得到现有成员的支持 贝勒癌症中心生物统计学共享资源，经验丰富，已建立 与这个孢子的研究成员合作。最终，这起案件中的孢子调查者 应用程序将受益于生物统计核心的基础设施，以确保执行 创新和高质量的翻译研究。

The Biostatistics Core for the Baylor College of Medicine's Lymphoma SPORE will provide comprehensive and centralized support that integrates the biostatistical activities of the research projects in this SPORE program. The specific aims of this core are to: 1. coordinate and manage the statistical activities of the SPOREto ensure that investigators have ready access to biostatistical consultation; 2. provide biostatistical expertise in study planning and conduct of clinical trials and preclinical validation experiments; 3. coordinate data management activities in close collaborationwith the Clinical Core; and 4. provide comprehensive support for data analysis including safety/toxicity monitoring, interim reviews of data, final analysis, and reporting. This Lymphoma SPORE application proposes iterative laboratory-clinical studies which entails scientific and statistical input for the ensuing animal experiments and clinical trials. The Biostatistics Core personnel will incorporate sound experimental principles in study planning and development, implement a coordinated data management system, and facilitate provision of timely and high-quality statistical analysis and data interpretation. The Biostatistics Core of this SPORE application will draw support from existing members of Baylor Cancer Center's Biostatistics Shared Resource who are highly experienced and have established collaborations with the research members of this SPORE. Ultimately, the SPORE investigators in this application will benefit from the infrastructure of the Biostatistics Core to ensure the implementation of innovative and high-quality translational studies.