Biostatistics and Data Management

生物统计学和数据管理

• 批准号: 7919504
• 负责人: Heidi L Weiss
• 金额: $ 14.37万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7919504
• 关键词: Animal Experiments; Biometry; Biostatistics Core; Biostatistics Shared Resource; Cancer Center; Clinical; Clinical Research; Clinical Trials; Collaborations; Conduct Clinical Trials; Consultations; Data; Data Analyses; Development Plans; Ensure; Human Resources; Laboratories; Lymphoma; Medicine; Monitor; Reporting; Reproduction spores; Research; Research Infrastructure; Research Personnel; Research Project Grants; Safety; Statistical Data Interpretation; System; Toxic effect; Validation; college; data management; experience; innovation; member; pre-clinical; programs; research study; sound; translational study

The Biostatistics Core for the Baylor College of Medicine's Lymphoma SPORE will provide comprehensive and centralized support that integrates the biostatistical activities of the research projects in this SPORE program. The specific aims of this core are to: 1. coordinate and manage the statistical activities of the SPOREto ensure that investigators have ready access to biostatistical consultation; 2. provide biostatistical expertise in study planning and conduct of clinical trials and preclinical validation experiments; 3. coordinate data management activities in close collaborationwith the Clinical Core; and 4. provide comprehensive support for data analysis including safety/toxicity monitoring, interim reviews of data, final analysis, and reporting. This Lymphoma SPORE application proposes iterative laboratory-clinical studies which entails scientific and statistical input for the ensuing animal experiments and clinical trials. The Biostatistics Core personnel will incorporate sound experimental principles in study planning and development, implement a coordinated data management system, and facilitate provision of timely and high-quality statistical analysis and data interpretation. The Biostatistics Core of this SPORE application will draw support from existing members of Baylor Cancer Center's Biostatistics Shared Resource who are highly experienced and have established collaborations with the research members of this SPORE. Ultimately, the SPORE investigators in this application will benefit from the infrastructure of the Biostatistics Core to ensure the implementation of innovative and high-quality translational studies.

贝勒医学院淋巴瘤孢子的生物统计学核心将提供全面的 和集中支持，将研究项目的生物统计学活动整合到该SPORE中 程序. 该核心的具体目标是： 1.协调和管理SPORE的统计活动，以确保研究者 随时获得生物统计咨询; 2.在研究规划和临床试验和临床前研究中提供生物统计学专业知识 验证实验; 3.与临床中心密切合作，协调数据管理活动;以及 4.为数据分析提供全面支持，包括安全性/毒性监测、中期 审查数据、最终分析和报告。 这种淋巴瘤孢子应用程序提出了迭代的实验室临床研究，这需要科学和 用于随后的动物实验和临床试验的统计输入。生物统计学核心人员将 在研究规划和开发中纳入合理的实验原则， 管理系统，并促进及时提供高质量的统计分析和数据 解释。此SPORE应用程序的生物统计学核心将得到现有成员的支持， 贝勒癌症中心的生物统计学共享资源，他们经验丰富， 与这个孢子的研究成员合作。最终，SPORE调查人员在这 应用程序将受益于生物统计核心的基础设施，以确保实施 创新和高质量的翻译研究。