Corticospinal Function after Spinal Cord Injury
脊髓损伤后的皮质脊髓功能
基本信息
- 批准号:8828399
- 负责人:
- 金额:$ 31.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-30 至 2015-02-05
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAffectAmyotrophic Lateral SclerosisAreaAxonBehaviorCentral Nervous System DiseasesCervical spinal cord injuryCorticospinal TractsDataDevelopmentDistalEffectivenessFingersGenerationsGoalsImpairmentIndividualKnowledgeLesionLocationMagnetic Resonance ImagingMapsMeasuresMethodologyMethodsMotorMotor NeuronsMotor outputMovementMultiple SclerosisMuscleNeuronavigationNeuronsPathway interactionsPatientsProtocols documentationRecoveryRecovery of FunctionResearchResidual stateRestSpinalSpinal cord injurySpinal cord injury patientsStrokeSurfaceSystemTestingTherapeutic InterventionTrainingTranscranial magnetic stimulationUpper ExtremityUpper limb movementWorkarmbasebiceps brachii muscledisabilitygraspimprovedmotor disordermotor function recoverynovelpublic health relevancerelating to nervous systemresearch studyresponsetransmission process
项目摘要
DESCRIPTION (provided by applicant): Our overall goal is to develop new strategies to enhance the recovery of upper-limb function after spinal cord injury (SCI). We propose to use modern electrophysiological methods to enhance the efficacy of residual corticospinal connections. Defining the neural basis by which corticospinal volleys generate muscle responses will provide crucial information required to maximize residual motor output. Our specific goals are to: 1) determine the temporal organization of corticospinal volleys and location
of motor cortical representations of upper-limb muscles after incomplete cervical SCI and 2) develop methodologies to promote recovery of function. We focus on reach and grasp movements because of their importance in daily life activities. Multiple descending volleys in the corticospinal tract generate multiple peaks in muscle responses (indirect (I) - waves). In Aim 1, paired transcranial magnetic stimulation (TMS) will be used to examine I-waves in surface electromyographic (EMG) recordings of upper-limb muscles during reach and grasp. The temporal organization of the early and late I-waves and contribution to voluntary EMG activity will be determined. In Aim 2, the size (and location) of cortical maps of upper-limb muscles will be defined using TMS guided by a frameless magnetic resonance imaging neuronavigation system. Together, these studies in individuals with and without SCI will determine mechanisms of corticospinal reorganization during reach and grasp. In Aim 3, we will use novel TMS paradigms to maximize the effectiveness of residual corticospinal connections by engaging mechanisms of corticospinal reorganization. Repeated paired-TMS will target functionally relevant I- wave intervals at affected motor cortical locations. Training of reach and grasp movements will be combined with paired-TMS-paradigms to further enhance behaviorally relevant plasticity and recovery of function. The proposed experiments will provide new knowledge on mechanisms of corticospinal reorganization involving reach and grasp movements which will be used to guide functionally-relevant plasticity-inducing protocols to enhance recovery. There are no universally accepted treatments for upper-limb motor disability after SCI and other CNS disorders that affect the corticospinal pathway. Current treatments for reach and grasp functions result in limited improvements. Thus, there is a pressing need to develop new strategies to promote recovery of meaningful function after SCI.
描述(由申请人提供):我们的总体目标是开发新策略来促进脊髓损伤(SCI)后上肢功能的恢复。我们建议使用现代电生理学方法来增强残余皮质脊髓连接的功效。定义皮质脊髓齐射产生肌肉反应的神经基础将提供最大化残余运动输出所需的关键信息。我们的具体目标是:1)确定皮质脊髓齐射的时间组织和位置
2) 开发促进功能恢复的方法。我们关注伸手和抓握动作,因为它们在日常生活活动中很重要。皮质脊髓束中的多次下降截击会产生肌肉反应的多个峰值(间接 (I) - 波)。在目标 1 中,配对经颅磁刺激 (TMS) 将用于检查伸手和抓握过程中上肢肌肉表面肌电图 (EMG) 记录中的 I 波。早期和晚期 I 波的时间组织以及对自愿肌电图活动的贡献将被确定。在目标 2 中,将使用由无框架磁共振成像神经导航系统引导的 TMS 来定义上肢肌肉皮质图的大小(和位置)。总之,这些针对患有和未患有 SCI 的个体的研究将确定在触及和抓握过程中皮质脊髓重组的机制。在目标 3 中,我们将使用新颖的 TMS 范例,通过参与皮质脊髓重组机制,最大限度地提高残余皮质脊髓连接的有效性。重复配对 TMS 将针对受影响的运动皮层位置功能相关的 I 波间隔。伸展和抓握动作的训练将与配对 TMS 范式相结合,以进一步增强行为相关的可塑性和功能恢复。拟议的实验将提供有关涉及触及和抓握运动的皮质脊髓重组机制的新知识,这将用于指导功能相关的可塑性诱导方案以促进恢复。对于 SCI 后的上肢运动障碍和影响皮质脊髓通路的其他中枢神经系统疾病,目前尚无普遍接受的治疗方法。目前对触及和抓握功能的治疗导致的改善有限。因此,迫切需要制定新策略来促进 SCI 后有意义功能的恢复。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Monica A Perez其他文献
Monica A Perez的其他文献
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{{ truncateString('Monica A Perez', 18)}}的其他基金
Spinal Cord Stimulation for Functional Recovery in Humans with Tetraplegia
脊髓刺激促进四肢瘫痪患者功能恢复
- 批准号:
10311398 - 财政年份:2022
- 资助金额:
$ 31.57万 - 项目类别:
Spinal Cord Stimulation for Functional Recovery in Humans with Tetraplegia
脊髓刺激促进四肢瘫痪患者功能恢复
- 批准号:
10542337 - 财政年份:2022
- 资助金额:
$ 31.57万 - 项目类别:
From Neural Control of Movement to Treatments for Spinal Cord Injury
从运动的神经控制到脊髓损伤的治疗
- 批准号:
10240128 - 财政年份:2021
- 资助金额:
$ 31.57万 - 项目类别:
From Neural Control of Movement to Treatments for Spinal Cord Injury
从运动的神经控制到脊髓损伤的治疗
- 批准号:
10406361 - 财政年份:2021
- 资助金额:
$ 31.57万 - 项目类别:
From Neural Control of Movement to Treatments for Spinal Cord Injury
从运动的神经控制到脊髓损伤的治疗
- 批准号:
10631942 - 财政年份:2021
- 资助金额:
$ 31.57万 - 项目类别:
Closed loop control of vibration for muscle spasms after human spinal cord injury: efficacy and mechanism
人脊髓损伤后肌肉痉挛的振动闭环控制:功效和机制
- 批准号:
10079030 - 财政年份:2019
- 资助金额:
$ 31.57万 - 项目类别:
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