2020 Molecular & Cellular Neurobiology Gordon Research Conference and Gordon Research Seminar

项目摘要 2020年戈登分子和细胞神经生物学研究会议将汇聚 来自学术界和工业界的神经科学家讨论神经症研究的最新突破 系统。最新的技术创新，包括光遗传学，基因组编辑，组织清除，超级 分辨率显微镜和单细胞测序使对大脑的研究以前所未有的速度 详细程度。科学会议将重点介绍神经系统发育的最新发现， 突触功能，潜在行为的神经回路，脑成像和连接学，以及分子和 神经疾病的细胞机制，包括神经退行性疾病和神经精神障碍。一个 这次国际会议的主要目标将是促进各级科学家和来自 不同的背景，以促进神经科学研究的新合作和新方向。 将鼓励在科学会议和留出更多非正式讨论的时间进行讨论 互动。为了促进下一代神经科学家，将从摘要中挑选简短的演讲。 由学生、博士后研究员和初级教职员工提交。GRC还将推出Power Hour， 为所有与会者举行的非正式会议，讨论女性在科学领域面临的挑战，并支持专业人士 通过为讨论和指导提供一个开放的论坛，促进妇女的成长。最后，将在此GRC之前 戈登分子和细胞神经生物学研究研讨会(GRS)，将作主旨演讲 演讲者，并仅对学生和博士后研究员开放。GRS将作为实习生的论坛 拓宽他们的同行网络，并将补充GRC将来自世界各地的科学家聚集在一起 讨论和确定分子和细胞神经生物学的新方向。最新技术的爆炸性发展 进展使神经科学家能够研究基础和翻译神经科学 史无前例的细节。例如，光遗传学提供了关于何时以及如何激活一种 选定的神经元(S)或神经回路会引起生理或病理效应。IPSC技术成就了它 从病人身上分离体细胞并产生神经学和精神病学的“细胞模型”是可能的 通过将这些细胞分化(或直接转换)成精确类型的神经元和神经胶质细胞而导致的疾病。基因组学 蛋白质组学允许识别易感基因和复杂信号网络的全球视角。 表观遗传学研究可能揭示突触可塑性、学习和记忆的一种新的编码机制。基因组 使用CRISPR/Cas9进行编辑在为建模研究生成特定突变方面具有革命性 并用于在人类细胞和神经元中进行全基因组修饰筛选。最近，单细胞 测序揭示了大脑中新类型的细胞和新的细胞状态，并使研究 全脑连接学。该领域的领先研究人员将介绍这些前沿问题和他们的 会议将讨论其影响。

Project Summary The 2020 Gordon Research Conference on Molecular and Cellular Neurobiology will bring together neuroscientists from academia and industry to discuss the latest breakthroughs in the study of the nervous system. Recent technological innovations, including optogenetics, genome editing, tissue clearing, super resolution microscopy, and single cell sequencing have empowered the study of the brain at an unprecedented level of detail. Scientific sessions will highlight recent discoveries on the development of the nervous system, synaptic function, neural circuits underlying behavior, brain imaging and connectomics, and molecular and cellular mechanisms of neurological diseases, including neurodegenerative and neuropsychiatric disorders. A major goal of this international conference will be to foster interactions among scientists at all levels and from different backgrounds in order to stimulate new collaborations and directions of neuroscience research. Discussion will be encouraged both in the scientific sessions as well as during time set aside for more informal interactions. To promote the next generation of neuroscientists, short talks will be selected from abstracts submitted by students, postdoctoral fellows and junior faculty members. The GRC will also feature a Power Hour, an informal session for all attendees to discuss challenges women face in science and to support the professional growth of women by providing an open forum for discussion and mentoring. Finally, this GRC will be preceded by a Gordon Research Seminar (GRS) on Molecular and Cellular Neurobiology, which will feature a keynote speaker and be open only to students and postdoctoral fellows. The GRS will serve as a forum for trainees to broaden their peer network and will complement the GRC in bringing together scientists from around the world to discuss and identify new directions in molecular and cellular neurobiology. An explosion in recent technological advances has empowered neuroscientists to examine fundamental and translational neuroscience in unprecedented detail. For example, optogenetics has provided insight into when and how the activation of a selected neuron(s) or neural circuit causes physiological or pathological effects. iPSC technology makes it possible to isolate somatic cells from patients and generate “cell models” of neurological and psychiatric disorders by differentiating (or directly converting) these cells into precise types of neurons and glia. Genomics and proteomics allow for identification of susceptibility genes and a global view of intricate signaling networks. Epigenetic studies may reveal a novel coding mechanism of synaptic plasticity, learning and memory. Genome editing using CRISPR/Cas9 has been revolutionary in both generating specific mutations for modeling studies and for performing genomewide modifier screens in human cells and neurons. Most recently, single cell sequencing is revealing novel types of cells in the brain and novel cell states and is empowering the study of whole brain connectomics. The leading researchers in the field will present these cutting-edge issues and their implications will be discussed at the meeting.