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2022 Membrane Transport Proteins GRC/GRS

2022 膜转运蛋白 GRC/GRS

基本信息

批准号：
9991402
负责人：
AURELIO GALLI
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9991402
关键词：
Academia Academy Adderall Address Advocacy Animal Model Anniversary Area Attention deficit hyperactivity disorder Australia Basic Science Biochemical Biogenesis Biological Biophysics Brain Canada Carrier Proteins Cells Cessation of life Christianson syndrome Climate Clinical Collaborations Communities Cystic Fibrosis Data Defect Development Diabetes Mellitus Discipline Disease Diuretics Ensure Environment Europe Fluoxetine Fostering Functional disorder Future Genes Genetic Genetic Diseases Goals Government Hour Human Genome Industry International Invertebrates Ion Channel Ion Pumps Ions Knowledge Lead Leadership Life Link Malignant Neoplasms Medical Medicine Membrane Potentials Membrane Transport Proteins Mental Depression Mentors Metabolic Migraine Mind Minority Molecular Nerve Degeneration Neurologic Neurons Neurotransmitters Nuclear Pore Nutrient Omeprazole Organism Participant Patients Perception Pharmaceutical Preparations Pharmacology Pharmacotherapy Physiological Physiology Policies Postdoctoral Fellow Process Protein translocation Proteins Proton Pump Publishing Rare Diseases Regulation Reporting Research Research Personnel Ritalin SK-Furosemide Science Science, Technology, Engineering and Mathematics Scientist Secondary Schools Secure Selective Serotonin Reuptake Inhibitor Sodium Chloride System Techniques Therapeutic Time Transcranial magnetic stimulation Translating Transmembrane Transport Ulcer Underrepresented Minority Woman Work autism spectrum disorder base career clinically relevant design disease phenotype diversity and inclusion dopamine transporter drug discovery equity diversity and inclusion gender equity genetic variant graduate student improved inhibitor/antagonist innovation insight lectures member neurotransmitter release next generation notch protein novel outreach peer peptide hormone posters prevent programs rare genetic disorder recruit serotonin transporter single-molecule FRET skills success supportive environment symporter symposium therapeutic target trafficking

项目摘要

PROJECT SUMMARY The 2020 Gordon Research Conference on Membrane Transporter Proteins titled “Biomedical Transporters: Physiology, Dysfunction and Targets of Pharmacotherapy” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and thought contribute to a gamut of highly prevalent (autism, depression, diabetes) as well as orphan and rare diseases (Christianson syndrome, mucoviscidosis), membrane transporters remain largely unexplored in their potential as therapeutic targets, and in their association to specific diseases. The impetus in organizing this conference is to link genetic, molecular and mechanistic insights on clinically important membrane transporters, including carriers, ion channels and pumps, to physiological function and disease-related malfunction. The intent is to offer and discuss opportunities for the development of pharmacotherapies targeting transporter dysfunctions in disease states. N ine highly interdisciplinary scientific sessions are bringing together topics, approaches and novel ideas that are not conventionally related. These range from genetics of transporter and ion channels in disease states, to unconventional animal models to study transporter, or particular approaches such as single-molecule fluorescence resonance energy transfer and transcranial magnetic stimulation. This prevents the perception of a particular approach or topic dominating the conference and amplifies opportunities for discussion of new ideas. New topics have been introduced (e.g. peptides, hormones, and neurotransmitter release: the importance of transporters in the gut and brain; invertebrates as animal models to study transporter functions, etc.) that have never been covered in this conference. Ample discussion time after each talk, daily posters, and afternoon free time allow for informal discussion, networking and forming new collaborations. Other special features of the 2020 conference include the Gordon Research Seminar for young investigators, and the Power Hour for the promotion of women scientists. Notably, we secured Dr. Imogen Coe as the Discussion Leader of the Power Hour. Dr. Coe is internationally recognized as a Canadian thought leader in the area of equity, diversity and inclusion (EDI) in science, technology, engineering and math (STEM). She has advised academia, government and industry on the best practices and approaches to improve EDI in STEM, particularly in the Canadian post-secondary education (PSE) sector. She has written and spoken about these issues extensively for platforms such as the Globe and Mail, iPolitics and the CBC. In 2016, she was recognized as one of Canada's Top 100 Women for her advocacy work promoting equity in STEM. We feel that this conference will offer plenty of scientific opportunities fostering an environment centered on EDI.

项目总结