High-density markers of mother-infant bio-behavioral activity "in the wild": Developing a mobile-sensing paradigm to examine transmission of mental health risks

项目摘要 社会情绪发展的主要理论认为，自我调节的适应模式反映了 积累了成千上万个人的日常痛苦经历。尤其是家长的努力， 他们认为婴儿的痛苦为发展自我调节技能提供了关键的输入。影响因素 照顾者的压力或情绪障碍等障碍被认为限制了父母早期提供这种服务的能力 支持.因此，早期出现的母婴互动模式被认为是一个重要的理论 心理健康风险从照顾者传递给子女的机制。然而，根据经验， 这些理论的证据是稀缺的，因为它还没有可能系统地捕捉事件， 在母亲和婴儿的日常活动中发生的痛苦。此外，大多数研究无法理清 婴儿和母亲心理生物学因素之间的复杂相互作用。例如，高度挑剔的婴儿 更有可能给父母带来压力和压力，从而可能影响父母的监管努力， 潜在地加剧了他们自己的早期生物倾向。 需要收集母亲和婴儿之间日常互动细节的数据集， 发展精神病理风险的基本生物行为机制。在未来，如此丰富的数据集可以 还为新兴的“及时”干预提供了基础， 在日常活动中给予支持和保证。从而推动发展领域 精神病理学，这项建议将利用新兴的“可穿戴”或移动传感器技术，以捕捉 在典型的日常生活中发生的婴儿痛苦事件和随后的母亲调节努力 婴儿及其母亲的活动。 本计画的研究目的为：1）发展一个行动感测平台， 参与者日常生活中母婴痛苦相关活动的详细标记，通过 一套同步的“可穿戴”生理学、音频和接近传感器，一旦经过验证， 平台2）调查适应不良的母婴互动动态的日常机制 这个建议的培训目标是1）发展我的专业知识与最先进的计算工具， 在“野外”研究母婴活动，让我前所未有地接触到生物的动态过程， 行为发展，2）为我提供机会，将我的工作与发展领域联系起来 精神病理学因此，拟议的K01是我开发研究计划的关键一步， 利用日常活动的丰富动态来支持理论驱动的临床创新。

Project Summary Major theories of socioemotional development suggest that adaptive patterns of self-regulation reflect the accumulation of thousands of individual daily experiences of distress. In particular, parents’ efforts to regulate their infants’ distress are thought to provide critical inputs to developing self-regulation skills. Factors affecting caregiving, such as caregiver stress or mood disorders, are thought to limit parents’ ability to provide this early support. Thus, early-emerging patterns of mother-infant interaction are theorized to be an important mechanism by which mental health risks are transmitted from caregivers to their children. However, empirical evidence for these theories are scarce, as it has not been possible to systematically capture episodes of distress as they occur in day-to-day mother and infant activity. Additionally, most studies cannot disentangle complex interactions between infant and maternal psychobiological factors. For example, highly fussy infants are more likely to stress and overwhelm their parents, thereby likely affecting parental regulation efforts and potentially exacerbating their own early biological predispositions. Datasets capturing the details of daily interactions between mothers and their infants are needed to access the basic bio-behavioral mechanisms of developing psychopathology risk. In the future, such rich datasets could also provide a foundation for emerging “just in time” interventions that could provide mothers with real-time support and reassurance during day-to-day activities. To thus advance the field of developmental psychopathology, this proposal will leverage emerging “wearable” or mobile-sensor technologies to capture episodes of infant distress and subsequent maternal regulation efforts as they occur in the typical day-to-day activities of infants and their mothers. The research aims of this proposal are 1) to develop a mobile-sensing platform that will automatically detect detailed markers of mother-infant distress-related activity as participants go about their daily lives, captured via a synchronized suite of “wearable” physiology, audio and proximity sensors, and once validated, to use this platform to 2) investigate the daily mechanisms of maladaptive mother-infant interaction dynamics The training goals of this proposal are to 1) develop my expertise with state-of-the art computational tools to study mother-infant activity in the “wild”, allowing me unprecedented access to the dynamic processes of bio- behavioral development, and 2) to provide me the opportunity bridge my work to the domain of developmental psychopathology. The proposed K01 is thus a key step in my goal to develop a research program that can harness the rich dynamics of day-to-day activity to support theoretically-driven clinical innovations.